급성 A형 바이러스 간염 후 발생한 자가면역 간염
The pathogenesis of autoimmune hepatitis (AIH) is unclear, but viral infections have been proposed as a potential trigger in patients with genetic predisposition. We report a case of AIH following acute hepatitis A (AHA). A 57-year-old woman presented with fatigue and pitting edema for last 3 months...
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| Veröffentlicht in: | The Korean journal of gastroenterology 2011-05, Vol.57 (5), p.315 |
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| container_title | The Korean journal of gastroenterology |
| container_volume | 57 |
| creator | 김영두 Young Doo Kim 김경아 Kyung Ah Kim 류우선 Woo Sun Rou 이준성 June Sung Lee 송태준 Tae June Song 배원기 Won Ki Bae 김남훈 Nam Hoon Kim |
| description | The pathogenesis of autoimmune hepatitis (AIH) is unclear, but viral infections have been proposed as a potential trigger in patients with genetic predisposition. We report a case of AIH following acute hepatitis A (AHA). A 57-year-old woman presented with fatigue and pitting edema for last 3 months. She had been diagnosed as an AHA 15 months ago based on clinical features, biochemical tests and positive HAV IgM antibody at a local clinic. Her biochemical tests was normalized one month after AHA diagnosis, but the serum levels of aminotransferase started to rise four months after AHA diagnosis. Antinuclear antibody was positive at a titer of 1:40, and anti-smooth muscle antibody was also positive. Hypergammaglobulinemia and liver pathology were typical for AIH. The patients had a score of 17 according to the International Autoimmune Hepatitis Group`s system. She was given prednisolone and azathioprine and showed complete response to immunosuppressive therapy. The present case is the first report on AIH triggered by AHA in Korea. (Korean J Gastroenterol 2011;57:315-318) |
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We report a case of AIH following acute hepatitis A (AHA). A 57-year-old woman presented with fatigue and pitting edema for last 3 months. She had been diagnosed as an AHA 15 months ago based on clinical features, biochemical tests and positive HAV IgM antibody at a local clinic. Her biochemical tests was normalized one month after AHA diagnosis, but the serum levels of aminotransferase started to rise four months after AHA diagnosis. Antinuclear antibody was positive at a titer of 1:40, and anti-smooth muscle antibody was also positive. Hypergammaglobulinemia and liver pathology were typical for AIH. The patients had a score of 17 according to the International Autoimmune Hepatitis Group`s system. She was given prednisolone and azathioprine and showed complete response to immunosuppressive therapy. The present case is the first report on AIH triggered by AHA in Korea. 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| fulltext | fulltext |
| identifier | ISSN: 1598-9992 |
| ispartof | The Korean journal of gastroenterology, 2011-05, Vol.57 (5), p.315 |
| issn | 1598-9992 |
| language | kor |
| recordid | cdi_kiss_primary_2911523 |
| source | KoreaMed Synapse; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; KoreaMed Open Access |
| subjects | Autoimmune hepatitis Hepatitis A |
| title | 급성 A형 바이러스 간염 후 발생한 자가면역 간염 |
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