다제내성 결핵환자에서 Prothionamide에 의한 급성 간염
The prevalence of multi-drug resistant tuberculosis (MDR-TB), which is resistant to isoniazid and rifampin, has been increasing in Korea. And the side effects of 2nd line anti-tuberculosis medications, including drug-induced hepatitis, are well known. Although prothionamide (PTH) is one of the most...
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| Veröffentlicht in: | Tuberculosis and respiratory diseases 2011-03, Vol.70 (3), p.251 |
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| creator | 박준범 Jun Beom Park 박병훈 Byung Hoon Park 손지영 Ji Young Son 정지예 Ji Ye Jung 김은영 Eun Young Kim 임주은 Ju Eun Lim 이상훈 Sang Hoon Lee 이상국 Sang Kook Lee 김송이 Song Yee Kim 정원재 Won Jai Jung 임승택 Seung Taek Lim |
| description | The prevalence of multi-drug resistant tuberculosis (MDR-TB), which is resistant to isoniazid and rifampin, has been increasing in Korea. And the side effects of 2nd line anti-tuberculosis medications, including drug-induced hepatitis, are well known. Although prothionamide (PTH) is one of the most useful anti-TB medications and although TB medication-induced acute hepatitis is a severe complication, there are only a few published case reports about prothionamide induced hepatitis. In this case report, a 22 year old male was diagnosed with pulmonary MDR-TB and was administered 2nd line anti-TB mediations, including PTH. Afterwards, he had a spiking fever and his liver enzymes were more than 5 times greater than the upper limit of the normal range. He was then diagnosed with drug-induced hepatitis by liver biopsy. His symptoms and liver enzyme elevation were improved after stopping PTH. Accordingly, we report this case of an association between PTH and acute hepatitis. |
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| fulltext | fulltext |
| identifier | ISSN: 1738-3536 |
| ispartof | Tuberculosis and respiratory diseases, 2011-03, Vol.70 (3), p.251 |
| issn | 1738-3536 2005-6184 |
| language | kor |
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| source | KoreaMed Synapse; KoreaMed Open Access |
| subjects | Hepatitis Multidrug-Resistant Prothionamide Tuberculosis |
| title | 다제내성 결핵환자에서 Prothionamide에 의한 급성 간염 |
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