뽕잎추출물이 혈청 중의 활성산소 및 제거효소에 미치는 영향

This study was designed to investigate the effects of mulberry leaf extract (MLE) on oxygen radicals and their scavenger enzymes in serum of rats. Sprague-Dawley (SD) male rats (160 ± 10 g) were fed experimental diets (MLE-100 and MLE-300 groups) added 100 and 300 mg/kg Bw/day for 6 weeks. Triglyceride (TG) levels were significantly inhibited (10% and 20% ) in MLE-100 and MLE-300 groups, but there were no significant differences in total, LDL- and HDL- cholesterol levels in both MLE-100 and MLE-300 groups. Hydroxyl radical (·OH) formations resulted in a marked decreases (20~25%) in MLE-100 and MLE-300 groups compared with control group, while superoxide radical (O2-) and hydrogen peroxide formations resulted in a considerable decreases (7~10% and 5-10%) in MLE-100 and MLE-300 groups compared with control group. Lipid peroxide (LPO) and oxidized protein ( > C=0 group) productions resulted in a significant decreases (10% and 6-10%) in MLE-100 and MLE-300 groups compared with control group. Superoxide dismutase(SOD) and catalase (CAT) activities were remarkahly increased (30% and 40~55f%) in MLE-100 and MLE-300 groups, but glutathione peroxidase (GSHPx) activities were significantly increased(10~15%) in MLE-100 and MLE-300 groups compared with control group. These results suggest that anti-aging effect of mulberry leaf extract(MLE) may play a pivotal role in attenuating a various agerelated changes.