혈액투석 환자에서 사망의 예측인자로서 투석 초기의 혈청 생화학적 지표의 의의

혈액투석 환자에서 사망의 예측인자로서 투석 초기의 혈청 생화학적 지표의 의의

To investigate the influence of first six-month mean for serum biochemical markers, albumin, cho- lesterol, triglyceride, inorganic phosphate, BUN, creatinine, on survival in hemodialysis, we retrospectively analyzed the 57 patients who were monitored from the start of HD for more than 6 months betw...

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Veröffentlicht in:Kidney research and clinical practice 1997-06, Vol.16 (2), p.353
Hauptverfasser: 송기산, 이으우, 권건호, 전정배, 배성권, 지동한, 김문재
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container_issue 2
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container_title Kidney research and clinical practice
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creator 송기산
이으우
권건호
전정배
배성권
지동한
김문재
description To investigate the influence of first six-month mean for serum biochemical markers, albumin, cho- lesterol, triglyceride, inorganic phosphate, BUN, creatinine, on survival in hemodialysis, we retrospectively analyzed the 57 patients who were monitored from the start of HD for more than 6 months between January 1988 and December 1995. Exclusion criteria were as follows:' transfer to CAPD, transp- lantation or another dialysis center, HD for less than 6 months, noncompliant, death due to malignant disease, accident and self-withdrawal. The patients were divided into two groups according to the demographic characteristics and the median value of first six-month mean for serum biochemical markers. The mean age was 46.7±11.7 year, male-to fernale ratio was 1.6:1, diabetics were 12 (21.1%), and mean follow-up duration was 39.0±26.4 months. Among them 30 patients (52.6%) were died. Diabetic patients had significantly lower 1 year (63.6 vs. 88.8%, p
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Exclusion criteria were as follows:' transfer to CAPD, transp- lantation or another dialysis center, HD for less than 6 months, noncompliant, death due to malignant disease, accident and self-withdrawal. The patients were divided into two groups according to the demographic characteristics and the median value of first six-month mean for serum biochemical markers. The mean age was 46.7±11.7 year, male-to fernale ratio was 1.6:1, diabetics were 12 (21.1%), and mean follow-up duration was 39.0±26.4 months. Among them 30 patients (52.6%) were died. Diabetic patients had significantly lower 1 year (63.6 vs. 88.8%, p<0.05) and 3 year survival rate (19.1 vs. 62.2%, p<0.05) than nondiabetic patients. Low serum albumin(<3.5g/dl), low serum chole- sterol(<130mg/dl) and low serum P (<5.0mg/dl) groups were significantly lower 1 and 3 year survival rate than high serum albumin (63.6 vs. 97.0%; 25.5 vs. 74.6%, p<0.05), cholesterol (71.4 vs. 88.0%; 38.1 vs. 60.8%, p<0.05) and p (71.9 vs. 96.3% ; 47.1 vs. 62.9%, p<0.05) groups, respectively. There were no differences in survival rate according to sex, BUN, TG, and creatinine. By Cox's proportional hazard model, low serum albumin(odds ratio 1.98), cholesterol(odds ratio 1.60), and P(odds ratio 2.09) group were independent risk factors for early death. Low serum albumin level at the start of HD maintained during the follow-up period. Cholesterol and P showed similar results. 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Exclusion criteria were as follows:' transfer to CAPD, transp- lantation or another dialysis center, HD for less than 6 months, noncompliant, death due to malignant disease, accident and self-withdrawal. The patients were divided into two groups according to the demographic characteristics and the median value of first six-month mean for serum biochemical markers. The mean age was 46.7±11.7 year, male-to fernale ratio was 1.6:1, diabetics were 12 (21.1%), and mean follow-up duration was 39.0±26.4 months. Among them 30 patients (52.6%) were died. Diabetic patients had significantly lower 1 year (63.6 vs. 88.8%, p<0.05) and 3 year survival rate (19.1 vs. 62.2%, p<0.05) than nondiabetic patients. Low serum albumin(<3.5g/dl), low serum chole- sterol(<130mg/dl) and low serum P (<5.0mg/dl) groups were significantly lower 1 and 3 year survival rate than high serum albumin (63.6 vs. 97.0%; 25.5 vs. 74.6%, p<0.05), cholesterol (71.4 vs. 88.0%; 38.1 vs. 60.8%, p<0.05) and p (71.9 vs. 96.3% ; 47.1 vs. 62.9%, p<0.05) groups, respectively. There were no differences in survival rate according to sex, BUN, TG, and creatinine. By Cox's proportional hazard model, low serum albumin(odds ratio 1.98), cholesterol(odds ratio 1.60), and P(odds ratio 2.09) group were independent risk factors for early death. Low serum albumin level at the start of HD maintained during the follow-up period. Cholesterol and P showed similar results. 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Low serum albumin(<3.5g/dl), low serum chole- sterol(<130mg/dl) and low serum P (<5.0mg/dl) groups were significantly lower 1 and 3 year survival rate than high serum albumin (63.6 vs. 97.0%; 25.5 vs. 74.6%, p<0.05), cholesterol (71.4 vs. 88.0%; 38.1 vs. 60.8%, p<0.05) and p (71.9 vs. 96.3% ; 47.1 vs. 62.9%, p<0.05) groups, respectively. There were no differences in survival rate according to sex, BUN, TG, and creatinine. By Cox's proportional hazard model, low serum albumin(odds ratio 1.98), cholesterol(odds ratio 1.60), and P(odds ratio 2.09) group were independent risk factors for early death. Low serum albumin level at the start of HD maintained during the follow-up period. Cholesterol and P showed similar results. In conclusion, basal serum biochemical markers associated with visceral protein depletion such as low serum albumin, cholesterol and P seem to be early predictors of mortality in hemodialysis patients.]]></abstract><pub>대한신장학회</pub><tpages>8</tpages></addata></record>
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title 혈액투석 환자에서 사망의 예측인자로서 투석 초기의 혈청 생화학적 지표의 의의
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