미세변화형신증 환아의 자연살세포 활성능 및 항체의존 세포매개 세포독성

Recently it has been suggested that non-specific cellu- lar immunity not only plays an important role in the immune defence mechanism against tumors, virus and parasite, but a lso has an potential engagement to the damage of self tissue. Among the effector cells involved in the non-specfic immune reactions, natural killer (NK) cell and antibody dependent cell-mediated cytotoxicity (ADCC) effector cells are the principal targets in many of the investigations studying the immune mediated host defence and the mechanism of cell mediated tissue damages. We studied the activity of NK cell and ADCC of 24 pediatric patients (M:F=1.6:1, mean age 7.8±4.4 yrs) with pathologically diagnosed minimal change ne- phrotic syndrome (MCNS), and also in age matched healthy 20 children (M:F=1.7:1, mean age 6.1±3.1 yrs) as a control. The results are as follows; 1). NK cell activity of the MCNS patients; 24.2±18.8%, was decreased than that of controls; 36.2±19.8%; (p