각종 신질환에서 혈청 B형 간염 표면 항원 ( HBsAg ) 의 발현 빈도

Overall incidence of positive serum hepatitis-B antigen in Korean adult population is exceptio- nally higb with a positive rate of about 12%. In view of development of certain types of glome- rular diseases, especially membranous glomerulo- pathy in children associated with chronic hepa- titis-B infection presumably mediated by immune complex deposition, we studied the incidence rate of positive serum HBsAg and anti-HBs in 304 adult patients with various glomerular diseases and chronic renal failure evaluated at the Seve- rance Hospital, Yonsei University Medical Center during the period beginning from Jan. 1979 till Dec. 1983. As a control group, 2,634 subjects with no clinical and laboratory evidences of renal diseases were studied. 1) Serum hepatitis-B surface antigen was posi- tive in 52 patients out of 304 renal patients(17. 1 %)while the positive rate for normal control population was 12.3%. This difference was sta- tistically signifieant(p(0. 01). 2) Incidence rate for positive serum anti-HBs in patient and control group was not significantly different; 34.8,o (94/269) and 40.4%(639/1583) respectively. 3) As a group, patients with tiopsy proven nephrotic syndrome from various primary glome- rular diseases showed the highest positive incide- nce rate of HBsAg(24. 1%) compared to the patients with chronic renal failure(8. 9%) or chronic glomerulonephritis(18.6%). The positive inclidence rate in nephrotic patients was sign- ificantly higher than that of control group(p