Disseminated Mucormycosis : A Complication of Kidmey Transplantation

Disseminated Mucormycosis: A complication of kidney tranaplantation. A 64 year old male cadaveric renal allograft recipient developed dyspnea and a rapidly growing pulmonary nodule two months after transplantation. Can- dida albicans was repeatedly grown in the cultures of nose, throat, sputum and urine. The bronchial brush biopsy and percutaneous needle aspirate of the pulmonary nodule were unrevealing. Despite antifqngal therapy with flucytosine the patient died and disseminated mucormycosis involving the lungs, brain and transplanted kidney was found at autopsy. Mucormycosis should be considered in allo- graft recipients with a rapidly growing pulmo- nary nodule. An aggressive diagnostic and therapeutic approach including open biopsy, early discontinuation of immunosuppressive therapy and use of amphotericin B are indicated.