성인 미세변화신증후군 환자의 임상경과에 관한 연구
Objectives - A series of biopsy-proven 76adult onset minimal change nephrotic syndrome(MCNS) was analyzed to estimate the clinical courses including the rate and the pattern of response to corticosteroids or cytotoxic agents and the characteristics of relapse, Methods: The diagnoses of all cases wer...
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| Veröffentlicht in: | The Korean journal of medicine 1996-06, Vol.50 (6), p.805 |
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| creator | 박정하 Jung Ha Park 배성진 Sung Jin Bae 배상문 Sang Moon Bae 노명환 Myung Hwan Noh 김재석 Jae Seok Kim 박희승 Hee Seung Park 정원태 Won Tae Jung 김성은 Seong Eun Kim 김기현 Ki Hyun Kim 김영훈 Yeong Hoon Kim |
| description | Objectives - A series of biopsy-proven 76adult onset minimal change nephrotic syndrome(MCNS) was analyzed to estimate the clinical courses including the rate and the pattern of response to corticosteroids or cytotoxic agents and the characteristics of relapse, Methods: The diagnoses of all cases were made between 1985 and 1994. Mean follow up duration was 2.4±2.0 years. All the patients had the apparent onset of their disease when aged 16or more and presented with a full-blown nephrotic syndrome (proteinuria>3.0gm/day, serum albumin |
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| fullrecord | <record><control><sourceid>kiss</sourceid><recordid>TN_cdi_kiss_primary_1886871</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><kiss_id>1886871</kiss_id><sourcerecordid>1886871</sourcerecordid><originalsourceid>FETCH-LOGICAL-k424-88eb37e43ccbeb3e8d18455da17feac2b9198fdfe087e7b70dfc2f4c3f6ec9a33</originalsourceid><addsrcrecordid>eNotzL9KAzEcwPEMCpbaJ3DJCxxcLuklGaVoFQou3UuSS-CogjSTW8XbXDoobdErTk4Fa__ADfpC6e_eQUGn72f6HqAG4VREkqbsCLW8z3VMYyIZS9IG6kLxCWWF9x8VFNV-M67nT_D4Bu9l_VKE3QrX8xksJlDOMCwKeLgP6--w-YLpBIftuH5-xTBdhd3yGB06de1t679N1D8_63cuot5V97Jz2ouGLGGREFZTbhk1Rv_KiowI1m5ninBnlUm0JFK4zNlYcMs1jzNnEscMdak1UlHaRCd_22Hu_eB2lN-o0d2ACJEKTugPWEtbrA</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>성인 미세변화신증후군 환자의 임상경과에 관한 연구</title><source>KoreaMed Open Access</source><creator>박정하 ; Jung Ha Park ; 배성진 ; Sung Jin Bae ; 배상문 ; Sang Moon Bae ; 노명환 ; Myung Hwan Noh ; 김재석 ; Jae Seok Kim ; 박희승 ; Hee Seung Park ; 정원태 ; Won Tae Jung ; 김성은 ; Seong Eun Kim ; 김기현 ; Ki Hyun Kim ; 김영훈 ; Yeong Hoon Kim</creator><creatorcontrib>박정하 ; Jung Ha Park ; 배성진 ; Sung Jin Bae ; 배상문 ; Sang Moon Bae ; 노명환 ; Myung Hwan Noh ; 김재석 ; Jae Seok Kim ; 박희승 ; Hee Seung Park ; 정원태 ; Won Tae Jung ; 김성은 ; Seong Eun Kim ; 김기현 ; Ki Hyun Kim ; 김영훈 ; Yeong Hoon Kim</creatorcontrib><description>Objectives - A series of biopsy-proven 76adult onset minimal change nephrotic syndrome(MCNS) was analyzed to estimate the clinical courses including the rate and the pattern of response to corticosteroids or cytotoxic agents and the characteristics of relapse, Methods: The diagnoses of all cases were made between 1985 and 1994. Mean follow up duration was 2.4±2.0 years. All the patients had the apparent onset of their disease when aged 16or more and presented with a full-blown nephrotic syndrome (proteinuria>3.0gm/day, serum albumin<3.0gm/dl and edema). None had either past history of a nephrotic syndrome or other renal disease. All the cases were classified to five groups (16-25, 26-35, 36-45, 46-55, above 56) according to age and were analyzed. The clinical and laboratory information was obtained on each patient at the time of presentation and at last follow-up. Renal tissues were examined by light, fluorescence and electron micorscopy. The initial prednisolone was used at a dose of 40mg/day p.o. given up to 16weeks and the response to prednisolone therapy was evaluated, then tapered by 10mg every 2weeks. Cyclophosphamide was used at a dose of 2mg/kg/day p.o. given for 8-10weeks(maximal daily dose of 100mg) and the response to cyclophosphamide therapy was also evaluated. When there was no apparent response to cyclophosphamide therapy, the prednisolone regimen same as initial therapy was added consecutively after completion of cyclophosphamide therapy. All cases were reviewed retrospectively and analysed with SPSS/PC' program. Results: 1) The prevalence of young patients(16-25 year group) was higher(37cases, 49%). There was a preponderance of males(2.6:1). 2) The outcomes for sixty-nine patients, who given an initial course of prednisolone were 50cases (73%) in complete remission(CR), 9cases (13%) in a partial remission(PR) and 10cases(14%) remained nephrotic. The 34(68%) of 50cases who achieved complete remission were relapsed. 3) Cyclophosphamide was used in 35patients. The response to cyclophosphamide therapy were 7cases(20%) in CR, 12cases(34%) in PR and 16cases(46%) remained nephrotic till eighth weeks of treatment. A CR was obtained in 63%(10/16) with subsequent use of prednisolone after cyclophosphamide therapy because of poor response to cyclophosphamide. The cumulative CR rate was 60% (21/35) within 28th weeks of treatment. 4) The age of patients had no relationship to the response rate, time to response, relapse rate and number of relapse after prednisolone therapy. 5) At the final follow-up, 52cases(68%) were in CR, 6cases(8%) were in PR and 18cases(24%) were nephrotic, but all cases preserved normal renal function. Conclusion: Adult onset MCNS showed relatively good response with an daily 40mg of prednisolone as initial dose. The response to cyclophosphamide therapy in those who had inadequate response to initial prednisolone therapy or recurrent relapse was 60% of complete remission. Furthermore, the subsequent use of prednisolone after cyclophosphamide therapy is supposed to increase the response rate in case of poor cyclophosphamide response. Finally, as known the disease has a favorable out- come without renal function impairment.</description><identifier>ISSN: 1738-9364</identifier><language>kor</language><publisher>대한내과학회</publisher><subject>Clinical course ; Cyclophosphamide ; Minimal change nephrotic syndrome ; Prednisolone ; Treatment</subject><ispartof>The Korean journal of medicine, 1996-06, Vol.50 (6), p.805</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>박정하</creatorcontrib><creatorcontrib>Jung Ha Park</creatorcontrib><creatorcontrib>배성진</creatorcontrib><creatorcontrib>Sung Jin Bae</creatorcontrib><creatorcontrib>배상문</creatorcontrib><creatorcontrib>Sang Moon Bae</creatorcontrib><creatorcontrib>노명환</creatorcontrib><creatorcontrib>Myung Hwan Noh</creatorcontrib><creatorcontrib>김재석</creatorcontrib><creatorcontrib>Jae Seok Kim</creatorcontrib><creatorcontrib>박희승</creatorcontrib><creatorcontrib>Hee Seung Park</creatorcontrib><creatorcontrib>정원태</creatorcontrib><creatorcontrib>Won Tae Jung</creatorcontrib><creatorcontrib>김성은</creatorcontrib><creatorcontrib>Seong Eun Kim</creatorcontrib><creatorcontrib>김기현</creatorcontrib><creatorcontrib>Ki Hyun Kim</creatorcontrib><creatorcontrib>김영훈</creatorcontrib><creatorcontrib>Yeong Hoon Kim</creatorcontrib><title>성인 미세변화신증후군 환자의 임상경과에 관한 연구</title><title>The Korean journal of medicine</title><addtitle>대한내과학회지 (Korean J Med)</addtitle><description>Objectives - A series of biopsy-proven 76adult onset minimal change nephrotic syndrome(MCNS) was analyzed to estimate the clinical courses including the rate and the pattern of response to corticosteroids or cytotoxic agents and the characteristics of relapse, Methods: The diagnoses of all cases were made between 1985 and 1994. Mean follow up duration was 2.4±2.0 years. All the patients had the apparent onset of their disease when aged 16or more and presented with a full-blown nephrotic syndrome (proteinuria>3.0gm/day, serum albumin<3.0gm/dl and edema). None had either past history of a nephrotic syndrome or other renal disease. All the cases were classified to five groups (16-25, 26-35, 36-45, 46-55, above 56) according to age and were analyzed. The clinical and laboratory information was obtained on each patient at the time of presentation and at last follow-up. Renal tissues were examined by light, fluorescence and electron micorscopy. The initial prednisolone was used at a dose of 40mg/day p.o. given up to 16weeks and the response to prednisolone therapy was evaluated, then tapered by 10mg every 2weeks. Cyclophosphamide was used at a dose of 2mg/kg/day p.o. given for 8-10weeks(maximal daily dose of 100mg) and the response to cyclophosphamide therapy was also evaluated. When there was no apparent response to cyclophosphamide therapy, the prednisolone regimen same as initial therapy was added consecutively after completion of cyclophosphamide therapy. All cases were reviewed retrospectively and analysed with SPSS/PC' program. Results: 1) The prevalence of young patients(16-25 year group) was higher(37cases, 49%). There was a preponderance of males(2.6:1). 2) The outcomes for sixty-nine patients, who given an initial course of prednisolone were 50cases (73%) in complete remission(CR), 9cases (13%) in a partial remission(PR) and 10cases(14%) remained nephrotic. The 34(68%) of 50cases who achieved complete remission were relapsed. 3) Cyclophosphamide was used in 35patients. The response to cyclophosphamide therapy were 7cases(20%) in CR, 12cases(34%) in PR and 16cases(46%) remained nephrotic till eighth weeks of treatment. A CR was obtained in 63%(10/16) with subsequent use of prednisolone after cyclophosphamide therapy because of poor response to cyclophosphamide. The cumulative CR rate was 60% (21/35) within 28th weeks of treatment. 4) The age of patients had no relationship to the response rate, time to response, relapse rate and number of relapse after prednisolone therapy. 5) At the final follow-up, 52cases(68%) were in CR, 6cases(8%) were in PR and 18cases(24%) were nephrotic, but all cases preserved normal renal function. Conclusion: Adult onset MCNS showed relatively good response with an daily 40mg of prednisolone as initial dose. The response to cyclophosphamide therapy in those who had inadequate response to initial prednisolone therapy or recurrent relapse was 60% of complete remission. Furthermore, the subsequent use of prednisolone after cyclophosphamide therapy is supposed to increase the response rate in case of poor cyclophosphamide response. Finally, as known the disease has a favorable out- come without renal function impairment.</description><subject>Clinical course</subject><subject>Cyclophosphamide</subject><subject>Minimal change nephrotic syndrome</subject><subject>Prednisolone</subject><subject>Treatment</subject><issn>1738-9364</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNotzL9KAzEcwPEMCpbaJ3DJCxxcLuklGaVoFQou3UuSS-CogjSTW8XbXDoobdErTk4Fa__ADfpC6e_eQUGn72f6HqAG4VREkqbsCLW8z3VMYyIZS9IG6kLxCWWF9x8VFNV-M67nT_D4Bu9l_VKE3QrX8xksJlDOMCwKeLgP6--w-YLpBIftuH5-xTBdhd3yGB06de1t679N1D8_63cuot5V97Jz2ouGLGGREFZTbhk1Rv_KiowI1m5ninBnlUm0JFK4zNlYcMs1jzNnEscMdak1UlHaRCd_22Hu_eB2lN-o0d2ACJEKTugPWEtbrA</recordid><startdate>19960601</startdate><enddate>19960601</enddate><creator>박정하</creator><creator>Jung Ha Park</creator><creator>배성진</creator><creator>Sung Jin Bae</creator><creator>배상문</creator><creator>Sang Moon Bae</creator><creator>노명환</creator><creator>Myung Hwan Noh</creator><creator>김재석</creator><creator>Jae Seok Kim</creator><creator>박희승</creator><creator>Hee Seung Park</creator><creator>정원태</creator><creator>Won Tae Jung</creator><creator>김성은</creator><creator>Seong Eun Kim</creator><creator>김기현</creator><creator>Ki Hyun Kim</creator><creator>김영훈</creator><creator>Yeong Hoon Kim</creator><general>대한내과학회</general><scope>HZB</scope><scope>Q5X</scope></search><sort><creationdate>19960601</creationdate><title>성인 미세변화신증후군 환자의 임상경과에 관한 연구</title><author>박정하 ; Jung Ha Park ; 배성진 ; Sung Jin Bae ; 배상문 ; Sang Moon Bae ; 노명환 ; Myung Hwan Noh ; 김재석 ; Jae Seok Kim ; 박희승 ; Hee Seung Park ; 정원태 ; Won Tae Jung ; 김성은 ; Seong Eun Kim ; 김기현 ; Ki Hyun Kim ; 김영훈 ; Yeong Hoon Kim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-k424-88eb37e43ccbeb3e8d18455da17feac2b9198fdfe087e7b70dfc2f4c3f6ec9a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>1996</creationdate><topic>Clinical course</topic><topic>Cyclophosphamide</topic><topic>Minimal change nephrotic syndrome</topic><topic>Prednisolone</topic><topic>Treatment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>박정하</creatorcontrib><creatorcontrib>Jung Ha Park</creatorcontrib><creatorcontrib>배성진</creatorcontrib><creatorcontrib>Sung Jin Bae</creatorcontrib><creatorcontrib>배상문</creatorcontrib><creatorcontrib>Sang Moon Bae</creatorcontrib><creatorcontrib>노명환</creatorcontrib><creatorcontrib>Myung Hwan Noh</creatorcontrib><creatorcontrib>김재석</creatorcontrib><creatorcontrib>Jae Seok Kim</creatorcontrib><creatorcontrib>박희승</creatorcontrib><creatorcontrib>Hee Seung Park</creatorcontrib><creatorcontrib>정원태</creatorcontrib><creatorcontrib>Won Tae Jung</creatorcontrib><creatorcontrib>김성은</creatorcontrib><creatorcontrib>Seong Eun Kim</creatorcontrib><creatorcontrib>김기현</creatorcontrib><creatorcontrib>Ki Hyun Kim</creatorcontrib><creatorcontrib>김영훈</creatorcontrib><creatorcontrib>Yeong Hoon Kim</creatorcontrib><collection>Korean Studies Information Service System (KISS)</collection><collection>Korean Studies Information Service System (KISS) B-Type</collection><jtitle>The Korean journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>박정하</au><au>Jung Ha Park</au><au>배성진</au><au>Sung Jin Bae</au><au>배상문</au><au>Sang Moon Bae</au><au>노명환</au><au>Myung Hwan Noh</au><au>김재석</au><au>Jae Seok Kim</au><au>박희승</au><au>Hee Seung Park</au><au>정원태</au><au>Won Tae Jung</au><au>김성은</au><au>Seong Eun Kim</au><au>김기현</au><au>Ki Hyun Kim</au><au>김영훈</au><au>Yeong Hoon Kim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>성인 미세변화신증후군 환자의 임상경과에 관한 연구</atitle><jtitle>The Korean journal of medicine</jtitle><addtitle>대한내과학회지 (Korean J Med)</addtitle><date>1996-06-01</date><risdate>1996</risdate><volume>50</volume><issue>6</issue><spage>805</spage><pages>805-</pages><issn>1738-9364</issn><abstract>Objectives - A series of biopsy-proven 76adult onset minimal change nephrotic syndrome(MCNS) was analyzed to estimate the clinical courses including the rate and the pattern of response to corticosteroids or cytotoxic agents and the characteristics of relapse, Methods: The diagnoses of all cases were made between 1985 and 1994. Mean follow up duration was 2.4±2.0 years. All the patients had the apparent onset of their disease when aged 16or more and presented with a full-blown nephrotic syndrome (proteinuria>3.0gm/day, serum albumin<3.0gm/dl and edema). None had either past history of a nephrotic syndrome or other renal disease. All the cases were classified to five groups (16-25, 26-35, 36-45, 46-55, above 56) according to age and were analyzed. The clinical and laboratory information was obtained on each patient at the time of presentation and at last follow-up. Renal tissues were examined by light, fluorescence and electron micorscopy. The initial prednisolone was used at a dose of 40mg/day p.o. given up to 16weeks and the response to prednisolone therapy was evaluated, then tapered by 10mg every 2weeks. Cyclophosphamide was used at a dose of 2mg/kg/day p.o. given for 8-10weeks(maximal daily dose of 100mg) and the response to cyclophosphamide therapy was also evaluated. When there was no apparent response to cyclophosphamide therapy, the prednisolone regimen same as initial therapy was added consecutively after completion of cyclophosphamide therapy. All cases were reviewed retrospectively and analysed with SPSS/PC' program. Results: 1) The prevalence of young patients(16-25 year group) was higher(37cases, 49%). There was a preponderance of males(2.6:1). 2) The outcomes for sixty-nine patients, who given an initial course of prednisolone were 50cases (73%) in complete remission(CR), 9cases (13%) in a partial remission(PR) and 10cases(14%) remained nephrotic. The 34(68%) of 50cases who achieved complete remission were relapsed. 3) Cyclophosphamide was used in 35patients. The response to cyclophosphamide therapy were 7cases(20%) in CR, 12cases(34%) in PR and 16cases(46%) remained nephrotic till eighth weeks of treatment. A CR was obtained in 63%(10/16) with subsequent use of prednisolone after cyclophosphamide therapy because of poor response to cyclophosphamide. The cumulative CR rate was 60% (21/35) within 28th weeks of treatment. 4) The age of patients had no relationship to the response rate, time to response, relapse rate and number of relapse after prednisolone therapy. 5) At the final follow-up, 52cases(68%) were in CR, 6cases(8%) were in PR and 18cases(24%) were nephrotic, but all cases preserved normal renal function. Conclusion: Adult onset MCNS showed relatively good response with an daily 40mg of prednisolone as initial dose. The response to cyclophosphamide therapy in those who had inadequate response to initial prednisolone therapy or recurrent relapse was 60% of complete remission. Furthermore, the subsequent use of prednisolone after cyclophosphamide therapy is supposed to increase the response rate in case of poor cyclophosphamide response. Finally, as known the disease has a favorable out- come without renal function impairment.</abstract><pub>대한내과학회</pub><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 1738-9364 |
| ispartof | The Korean journal of medicine, 1996-06, Vol.50 (6), p.805 |
| issn | 1738-9364 |
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| subjects | Clinical course Cyclophosphamide Minimal change nephrotic syndrome Prednisolone Treatment |
| title | 성인 미세변화신증후군 환자의 임상경과에 관한 연구 |
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