심폐체외순환시 Sodium Nitroprusside , Nitroglycerin 및 Isosorbide Dinitrate 의 혈관이완효과

We have studied the vasodilating effect of bolus doses of sodium nitroprusside (SNP), nitro- glycerin (NTG), and isosorbide dinitrate (ISDN) in 40 patients during cardiopulmonary bypass with a constant pump flow. Blood volume of the venous reservoir and mean arterial pressure were recorded for 10 minutes after drug administration to detect changes in venous capacitance and arteriolar resistance. SNP 500 μg decreased mean blood pressure significantly more than NTG and ISDN compared with placebo. NTG 500 μg decreased mean blood pressure transiently at 1-4 min but significantly reduced reservoir blood volume. ISDN 500 μg increased mean blood pressure after drug administration, decreased reservoir blood volume less than NTG. We could conclude that SNP was more effective arteriolar vasodilator than NTG and ISDN, but NTG and ISDN were effective as a venodilator during cardiopulmonary bypass.