항Cholinesterase인 Neostigmine Methylsulfate의 신경근 차단작용

Background : Although the neuromuscular blocking properties of neostigmine have been known for many years, few assessment of this effect has been described in man. The aim of this study is to determine the effect of neostigmine on neuromuscular transmission in the absence of muscle relaxants. Method...

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Veröffentlicht in:Korean journal of anesthesiology 1997-06, Vol.32 (6), p.940
Hauptverfasser: 이승대, Seung Dae Lee, 황경호, kyung ho hwang, 이정석, Jeong Seok Lee, 강규식, Kyu Sik Kang, 박욱, Wook Park, 김성열, Sung Yell Kim
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container_title Korean journal of anesthesiology
container_volume 32
creator 이승대
Seung Dae Lee
황경호
kyung ho hwang
이정석
Jeong Seok Lee
강규식
Kyu Sik Kang
박욱
Wook Park
김성열
Sung Yell Kim
description Background : Although the neuromuscular blocking properties of neostigmine have been known for many years, few assessment of this effect has been described in man. The aim of this study is to determine the effect of neostigmine on neuromuscular transmission in the absence of muscle relaxants. Methods : ASA I, twenty unpremedicated patients who had given their informed consent were administered neostigmine 2.0 mg and atropine 0.5 mg under propofol, fentanyl, and O2-N2O(67%) anesthesia. Train-of-four responses were measured electromyographically using 0.2 msec, 2 Hz of supramaximal ulnar nerve stimulation every 20 sec. Results : There was no alteration in the train-of-four ratio, but the first twitch height decreased significantly after administration of neostigmine(p<0.05). Fasciculations were noted in the face and arms. Heart rate was decreased significantly to compare with preinjection value(p<0.05) while mean arterial pressure was not changed. Conclusions : It is concluded that even in clinical doses neostigmine may produce a depolarizing neuromuscular blockade, probably from the consequence of excessive accumulation of acetylcholine in the neuromuscular junction.(Korean J Anesthesiol 1997; 32: 940∼945)
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subjects Monitoring
neostigmine
train of four stimulation. Neuromuscular block
title 항Cholinesterase인 Neostigmine Methylsulfate의 신경근 차단작용
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