Midazolam 병합투여가 Propofol 정주에 의한 마취유도 및 각성에 미치는 영향

Background: Previous reports have demonstrated the synergistic interaction of midazolam and propofol in the induction of hypnosis. But there haer been some different views expnrsscd as to whether the synergism extended to hemodynamic effects. So we studied the effect of the co-administration of mida...

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Veröffentlicht in:Korean journal of anesthesiology 1999-08, Vol.37 (2), p.193
Hauptverfasser: 김창성, Chang Sung Kim, 심재용, Jae Yong Shim, 유건희, Keon Hee Ryu, 서소운, So Woon Seo, 최종호, Jong Ho Choi, 양내윤, Nae Yun Yang, 이재민, Jai Min Lee, 김은성, Eun Sung Kim
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container_issue 2
container_start_page 193
container_title Korean journal of anesthesiology
container_volume 37
creator 김창성
Chang Sung Kim
심재용
Jae Yong Shim
유건희
Keon Hee Ryu
서소운
So Woon Seo
최종호
Jong Ho Choi
양내윤
Nae Yun Yang
이재민
Jai Min Lee
김은성
Eun Sung Kim
description Background: Previous reports have demonstrated the synergistic interaction of midazolam and propofol in the induction of hypnosis. But there haer been some different views expnrsscd as to whether the synergism extended to hemodynamic effects. So we studied the effect of the co-administration of midazolam on induction dose, hemodynamic response, and recovery with the use of continuous infusion of propofol for induction, and the maintenance of anesthesia. Methods: Thirty-five patients undergoing elective surgery within 2 hours were randomly assigned to one of two groups formed according to the induction agents: Group P (continuous propofol infusion 1,200 mg/h), Group MP (midazolam 2 mg followed by continuous propofol infusion 1,200 mg/h). After induction, anesthesia was maintained with fentanyl (50 μg), N2O (70%), andpropofol (5 15 mg/kg/h). Outcome measures were propofol doses (induction and maintenance), hemodynamic responses (heart rate, blood pressure) during the induction period, emergence time (eye-opening to command), postoperative nausea and dizziness. Results: The induction dose of propofol was 29% less in Group MP compared to Group P but there was no significant difference in maintenance doses between the two groups. Heart rates showed no differences between the two groups, but the changes of mean arterial pressures from base line at 30 sec, 2 min and 5 min after intubation were greater and the emergence time was delayed in Group MP compared to Group P (P < 0.05). Conclusions: Midazolam potentiates the hypnotic action of propofol synergistically, but there was no evidence that the synergism extended to the blunting effect of propofol against the hypertensive response to intubation. (Korean J Anesthesiol 1999; 37: 193∼198)
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But there haer been some different views expnrsscd as to whether the synergism extended to hemodynamic effects. So we studied the effect of the co-administration of midazolam on induction dose, hemodynamic response, and recovery with the use of continuous infusion of propofol for induction, and the maintenance of anesthesia. Methods: Thirty-five patients undergoing elective surgery within 2 hours were randomly assigned to one of two groups formed according to the induction agents: Group P (continuous propofol infusion 1,200 mg/h), Group MP (midazolam 2 mg followed by continuous propofol infusion 1,200 mg/h). After induction, anesthesia was maintained with fentanyl (50 μg), N2O (70%), andpropofol (5 15 mg/kg/h). Outcome measures were propofol doses (induction and maintenance), hemodynamic responses (heart rate, blood pressure) during the induction period, emergence time (eye-opening to command), postoperative nausea and dizziness. Results: The induction dose of propofol was 29% less in Group MP compared to Group P but there was no significant difference in maintenance doses between the two groups. Heart rates showed no differences between the two groups, but the changes of mean arterial pressures from base line at 30 sec, 2 min and 5 min after intubation were greater and the emergence time was delayed in Group MP compared to Group P (P < 0.05). Conclusions: Midazolam potentiates the hypnotic action of propofol synergistically, but there was no evidence that the synergism extended to the blunting effect of propofol against the hypertensive response to intubation. (Korean J Anesthesiol 1999; 37: 193∼198)</description><identifier>ISSN: 2005-6419</identifier><identifier>EISSN: 2005-7563</identifier><language>kor</language><publisher>대한마취통증의학회(구 대한마취과학회)</publisher><subject>Anesthetics ; induction ; intravenous ; midazolam. 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Results: The induction dose of propofol was 29% less in Group MP compared to Group P but there was no significant difference in maintenance doses between the two groups. Heart rates showed no differences between the two groups, but the changes of mean arterial pressures from base line at 30 sec, 2 min and 5 min after intubation were greater and the emergence time was delayed in Group MP compared to Group P (P < 0.05). Conclusions: Midazolam potentiates the hypnotic action of propofol synergistically, but there was no evidence that the synergism extended to the blunting effect of propofol against the hypertensive response to intubation. (Korean J Anesthesiol 1999; 37: 193∼198)</description><subject>Anesthetics</subject><subject>induction</subject><subject>intravenous</subject><subject>midazolam. 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subjects Anesthetics
induction
intravenous
midazolam. Anesthesia
propofol
recovery
title Midazolam 병합투여가 Propofol 정주에 의한 마취유도 및 각성에 미치는 영향
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