기능성 소화불량 환자에서 Helicobacter pylori 감염과 위배출능의 상관관계

Background/Aims: The aim of this study was to investigate the effect of Helicobacter pylori (H. Pylori) infection on individual dyspeptic symptoms and parameters of gastric emptying rate in patients with functional dyspepsia. Methods: The thirty-two patients with functional dyspepsia were included in the study. The patients were divided into two groups (H. pylori-positive group and H. pylori-negative group). For the patients of both groups, eight symptoms of dyspepsia were scored to obtain an index of dyspepsia, and gastric emptying of a solid meal were studied. Results: Half gastric emptying time (t½) was 84.2±31.0 min in H. pylori positive group and 82.2±26.9 min in H. pylori-negative group. There was no correlation between gastric emptying and H. pylori infection. In comparison of dyspeptic subtype (ulcer like dyspepsia, dysmotility like dyspepsia, mixed type), symptom severity (2.6±0.6 vs 2.4±0.7, P=0.28), and dyspeptic index (2.6±1.2 vs 3.0±1.6, P=0.4), there was no difference between the patients with and without H. pylori infection. Moreover, individual dyspeptic symptoms except vomiting are not correlated with gastric emptying time. Conclusions: We believe that H. pylori infection does not affect gastric emptying and any individual symptoms of patients with functional dyspepsia. (Kor J Gastroenterol 2000;35:677 - 686)