만성활동성 간염과 간경변증 환자에서 혈청 4형 교원질의 의의
Background/Aims: Liver biosy is usually used to assess the expect of hepatic fibrosis, however, it is limited hecause serious complications have been reperted accasionally and frequent examinations are not adequate, Recently, the serum level of type IV collagen-7S domain is known to reflect the acti...
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| Veröffentlicht in: | The Korean journal of gastroenterology 1997-05, Vol.29 (1), p.65 |
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| creator | 이양일 Yang Il Lee 최성곤 Seong Kon Choi 금민수 Min Soo Keum 김영탁 Young Tak Kim 권혁만 Hyeok Man Kweon 김대현 Dae Hyun Kim 최영환 Young Hwan Choi 김성국 Sung Kook Kim 권영오 Young Oh Kweon 최용환 Yong Hwan Choi 정준모 Joon Mo Chung |
| description | Background/Aims: Liver biosy is usually used to assess the expect of hepatic fibrosis, however, it is limited hecause serious complications have been reperted accasionally and frequent examinations are not adequate, Recently, the serum level of type IV collagen-7S domain is known to reflect the activity of collagen synthesis in the process of fibrosis. We evaluate the clinical usefulness of serum type IV collagen as an indicator of hepatic fibrosis. Methods: Serurn levels of type IV collagen 7S domain were evaluated in 88 subjects including 20 healthy persons, 40 patients with chronic active hepatitis confirmed by liver biopsy and 28 patients with liver cirrhosis. The patients with chronic active hepatitis were classified as mild(18 cases), moderate(11 cases) and severe degree(11 cases) according to the histologic findings and the patients with liver cirrhosis were classified as Child A(10 cases), B(10 cases), C(8 cases) according to modified Childs classification. Serum level of type IV collagen-7S domain was measured by radioimmunoassay (RJA). Results: Serum type IV collagen-7S domain concentrations in patients with chronic active hepatitis and liver cirrhosis were significantly higher than those in healthy persons(p |
| format | Article |
| fullrecord | <record><control><sourceid>kiss</sourceid><recordid>TN_cdi_kiss_primary_1875367</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><kiss_id>1875367</kiss_id><sourcerecordid>1875367</sourcerecordid><originalsourceid>FETCH-kiss_primary_18753673</originalsourceid><addsrcrecordid>eNpjYeA0NLW00LW0tDTiYOAtLs5MMjA1MDc2Mbew5GQIfr28503Lxrcz57zunwlkKLza0PJm-p5Xm_eAWK827X29ueHNsrkKb2fOeDNvwpvpE960zFF4O6Pjzaa1CiZvZ0xVeLV1wpvZE94s73gzd4YCEAMRDwNrWmJOcSovlOZmkHZzDXH20M3OLC6OLyjKzE0sqow3tDA3NTYzN8YvCwCbh1KX</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>만성활동성 간염과 간경변증 환자에서 혈청 4형 교원질의 의의</title><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>이양일 ; Yang Il Lee ; 최성곤 ; Seong Kon Choi ; 금민수 ; Min Soo Keum ; 김영탁 ; Young Tak Kim ; 권혁만 ; Hyeok Man Kweon ; 김대현 ; Dae Hyun Kim ; 최영환 ; Young Hwan Choi ; 김성국 ; Sung Kook Kim ; 권영오 ; Young Oh Kweon ; 최용환 ; Yong Hwan Choi ; 정준모 ; Joon Mo Chung</creator><creatorcontrib>이양일 ; Yang Il Lee ; 최성곤 ; Seong Kon Choi ; 금민수 ; Min Soo Keum ; 김영탁 ; Young Tak Kim ; 권혁만 ; Hyeok Man Kweon ; 김대현 ; Dae Hyun Kim ; 최영환 ; Young Hwan Choi ; 김성국 ; Sung Kook Kim ; 권영오 ; Young Oh Kweon ; 최용환 ; Yong Hwan Choi ; 정준모 ; Joon Mo Chung</creatorcontrib><description>Background/Aims: Liver biosy is usually used to assess the expect of hepatic fibrosis, however, it is limited hecause serious complications have been reperted accasionally and frequent examinations are not adequate, Recently, the serum level of type IV collagen-7S domain is known to reflect the activity of collagen synthesis in the process of fibrosis. We evaluate the clinical usefulness of serum type IV collagen as an indicator of hepatic fibrosis. Methods: Serurn levels of type IV collagen 7S domain were evaluated in 88 subjects including 20 healthy persons, 40 patients with chronic active hepatitis confirmed by liver biopsy and 28 patients with liver cirrhosis. The patients with chronic active hepatitis were classified as mild(18 cases), moderate(11 cases) and severe degree(11 cases) according to the histologic findings and the patients with liver cirrhosis were classified as Child A(10 cases), B(10 cases), C(8 cases) according to modified Childs classification. Serum level of type IV collagen-7S domain was measured by radioimmunoassay (RJA). Results: Serum type IV collagen-7S domain concentrations in patients with chronic active hepatitis and liver cirrhosis were significantly higher than those in healthy persons(p<0.05). And significant correlations between the patients with chronic active hepatitis and with liver cirrhosis were also found(p<0.05). When chronic active hepatitis was divided into mild, moderate and severe degree there was a statistical significances(p<0.05). And significant correlations were found between the serum type IV collagen and the grade of the modified Childs classification(p<0.05). Conclusions: These results suggest that the measurement of serum type IV co]lagen may be a simple, noninvasive method and sensitive rnarker of hepatic fibrosis and also may reflect tbe status of progression in cirrhosis. (Korean J Gastroenterol 1997; 29:65 - 73)</description><identifier>ISSN: 1598-9992</identifier><language>kor</language><publisher>대한소화기학회</publisher><subject>Chronic active hepatitis ; Liver cirrhosis ; Serum type IV collagen-7S domain</subject><ispartof>The Korean journal of gastroenterology, 1997-05, Vol.29 (1), p.65</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids></links><search><creatorcontrib>이양일</creatorcontrib><creatorcontrib>Yang Il Lee</creatorcontrib><creatorcontrib>최성곤</creatorcontrib><creatorcontrib>Seong Kon Choi</creatorcontrib><creatorcontrib>금민수</creatorcontrib><creatorcontrib>Min Soo Keum</creatorcontrib><creatorcontrib>김영탁</creatorcontrib><creatorcontrib>Young Tak Kim</creatorcontrib><creatorcontrib>권혁만</creatorcontrib><creatorcontrib>Hyeok Man Kweon</creatorcontrib><creatorcontrib>김대현</creatorcontrib><creatorcontrib>Dae Hyun Kim</creatorcontrib><creatorcontrib>최영환</creatorcontrib><creatorcontrib>Young Hwan Choi</creatorcontrib><creatorcontrib>김성국</creatorcontrib><creatorcontrib>Sung Kook Kim</creatorcontrib><creatorcontrib>권영오</creatorcontrib><creatorcontrib>Young Oh Kweon</creatorcontrib><creatorcontrib>최용환</creatorcontrib><creatorcontrib>Yong Hwan Choi</creatorcontrib><creatorcontrib>정준모</creatorcontrib><creatorcontrib>Joon Mo Chung</creatorcontrib><title>만성활동성 간염과 간경변증 환자에서 혈청 4형 교원질의 의의</title><title>The Korean journal of gastroenterology</title><addtitle>대한소화기학회지</addtitle><description>Background/Aims: Liver biosy is usually used to assess the expect of hepatic fibrosis, however, it is limited hecause serious complications have been reperted accasionally and frequent examinations are not adequate, Recently, the serum level of type IV collagen-7S domain is known to reflect the activity of collagen synthesis in the process of fibrosis. We evaluate the clinical usefulness of serum type IV collagen as an indicator of hepatic fibrosis. Methods: Serurn levels of type IV collagen 7S domain were evaluated in 88 subjects including 20 healthy persons, 40 patients with chronic active hepatitis confirmed by liver biopsy and 28 patients with liver cirrhosis. The patients with chronic active hepatitis were classified as mild(18 cases), moderate(11 cases) and severe degree(11 cases) according to the histologic findings and the patients with liver cirrhosis were classified as Child A(10 cases), B(10 cases), C(8 cases) according to modified Childs classification. Serum level of type IV collagen-7S domain was measured by radioimmunoassay (RJA). Results: Serum type IV collagen-7S domain concentrations in patients with chronic active hepatitis and liver cirrhosis were significantly higher than those in healthy persons(p<0.05). And significant correlations between the patients with chronic active hepatitis and with liver cirrhosis were also found(p<0.05). When chronic active hepatitis was divided into mild, moderate and severe degree there was a statistical significances(p<0.05). And significant correlations were found between the serum type IV collagen and the grade of the modified Childs classification(p<0.05). Conclusions: These results suggest that the measurement of serum type IV co]lagen may be a simple, noninvasive method and sensitive rnarker of hepatic fibrosis and also may reflect tbe status of progression in cirrhosis. (Korean J Gastroenterol 1997; 29:65 - 73)</description><subject>Chronic active hepatitis</subject><subject>Liver cirrhosis</subject><subject>Serum type IV collagen-7S domain</subject><issn>1598-9992</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNpjYeA0NLW00LW0tDTiYOAtLs5MMjA1MDc2Mbew5GQIfr28503Lxrcz57zunwlkKLza0PJm-p5Xm_eAWK827X29ueHNsrkKb2fOeDNvwpvpE960zFF4O6Pjzaa1CiZvZ0xVeLV1wpvZE94s73gzd4YCEAMRDwNrWmJOcSovlOZmkHZzDXH20M3OLC6OLyjKzE0sqow3tDA3NTYzN8YvCwCbh1KX</recordid><startdate>19970523</startdate><enddate>19970523</enddate><creator>이양일</creator><creator>Yang Il Lee</creator><creator>최성곤</creator><creator>Seong Kon Choi</creator><creator>금민수</creator><creator>Min Soo Keum</creator><creator>김영탁</creator><creator>Young Tak Kim</creator><creator>권혁만</creator><creator>Hyeok Man Kweon</creator><creator>김대현</creator><creator>Dae Hyun Kim</creator><creator>최영환</creator><creator>Young Hwan Choi</creator><creator>김성국</creator><creator>Sung Kook Kim</creator><creator>권영오</creator><creator>Young Oh Kweon</creator><creator>최용환</creator><creator>Yong Hwan Choi</creator><creator>정준모</creator><creator>Joon Mo Chung</creator><general>대한소화기학회</general><scope>HZB</scope><scope>Q5X</scope></search><sort><creationdate>19970523</creationdate><title>만성활동성 간염과 간경변증 환자에서 혈청 4형 교원질의 의의</title><author>이양일 ; Yang Il Lee ; 최성곤 ; Seong Kon Choi ; 금민수 ; Min Soo Keum ; 김영탁 ; Young Tak Kim ; 권혁만 ; Hyeok Man Kweon ; 김대현 ; Dae Hyun Kim ; 최영환 ; Young Hwan Choi ; 김성국 ; Sung Kook Kim ; 권영오 ; Young Oh Kweon ; 최용환 ; Yong Hwan Choi ; 정준모 ; Joon Mo Chung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kiss_primary_18753673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>1997</creationdate><topic>Chronic active hepatitis</topic><topic>Liver cirrhosis</topic><topic>Serum type IV collagen-7S domain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>이양일</creatorcontrib><creatorcontrib>Yang Il Lee</creatorcontrib><creatorcontrib>최성곤</creatorcontrib><creatorcontrib>Seong Kon Choi</creatorcontrib><creatorcontrib>금민수</creatorcontrib><creatorcontrib>Min Soo Keum</creatorcontrib><creatorcontrib>김영탁</creatorcontrib><creatorcontrib>Young Tak Kim</creatorcontrib><creatorcontrib>권혁만</creatorcontrib><creatorcontrib>Hyeok Man Kweon</creatorcontrib><creatorcontrib>김대현</creatorcontrib><creatorcontrib>Dae Hyun Kim</creatorcontrib><creatorcontrib>최영환</creatorcontrib><creatorcontrib>Young Hwan Choi</creatorcontrib><creatorcontrib>김성국</creatorcontrib><creatorcontrib>Sung Kook Kim</creatorcontrib><creatorcontrib>권영오</creatorcontrib><creatorcontrib>Young Oh Kweon</creatorcontrib><creatorcontrib>최용환</creatorcontrib><creatorcontrib>Yong Hwan Choi</creatorcontrib><creatorcontrib>정준모</creatorcontrib><creatorcontrib>Joon Mo Chung</creatorcontrib><collection>Korean Studies Information Service System (KISS)</collection><collection>Korean Studies Information Service System (KISS) B-Type</collection><jtitle>The Korean journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>이양일</au><au>Yang Il Lee</au><au>최성곤</au><au>Seong Kon Choi</au><au>금민수</au><au>Min Soo Keum</au><au>김영탁</au><au>Young Tak Kim</au><au>권혁만</au><au>Hyeok Man Kweon</au><au>김대현</au><au>Dae Hyun Kim</au><au>최영환</au><au>Young Hwan Choi</au><au>김성국</au><au>Sung Kook Kim</au><au>권영오</au><au>Young Oh Kweon</au><au>최용환</au><au>Yong Hwan Choi</au><au>정준모</au><au>Joon Mo Chung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>만성활동성 간염과 간경변증 환자에서 혈청 4형 교원질의 의의</atitle><jtitle>The Korean journal of gastroenterology</jtitle><addtitle>대한소화기학회지</addtitle><date>1997-05-23</date><risdate>1997</risdate><volume>29</volume><issue>1</issue><spage>65</spage><pages>65-</pages><issn>1598-9992</issn><abstract>Background/Aims: Liver biosy is usually used to assess the expect of hepatic fibrosis, however, it is limited hecause serious complications have been reperted accasionally and frequent examinations are not adequate, Recently, the serum level of type IV collagen-7S domain is known to reflect the activity of collagen synthesis in the process of fibrosis. We evaluate the clinical usefulness of serum type IV collagen as an indicator of hepatic fibrosis. Methods: Serurn levels of type IV collagen 7S domain were evaluated in 88 subjects including 20 healthy persons, 40 patients with chronic active hepatitis confirmed by liver biopsy and 28 patients with liver cirrhosis. The patients with chronic active hepatitis were classified as mild(18 cases), moderate(11 cases) and severe degree(11 cases) according to the histologic findings and the patients with liver cirrhosis were classified as Child A(10 cases), B(10 cases), C(8 cases) according to modified Childs classification. Serum level of type IV collagen-7S domain was measured by radioimmunoassay (RJA). Results: Serum type IV collagen-7S domain concentrations in patients with chronic active hepatitis and liver cirrhosis were significantly higher than those in healthy persons(p<0.05). And significant correlations between the patients with chronic active hepatitis and with liver cirrhosis were also found(p<0.05). When chronic active hepatitis was divided into mild, moderate and severe degree there was a statistical significances(p<0.05). And significant correlations were found between the serum type IV collagen and the grade of the modified Childs classification(p<0.05). Conclusions: These results suggest that the measurement of serum type IV co]lagen may be a simple, noninvasive method and sensitive rnarker of hepatic fibrosis and also may reflect tbe status of progression in cirrhosis. (Korean J Gastroenterol 1997; 29:65 - 73)</abstract><pub>대한소화기학회</pub><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 1598-9992 |
| ispartof | The Korean journal of gastroenterology, 1997-05, Vol.29 (1), p.65 |
| issn | 1598-9992 |
| language | kor |
| recordid | cdi_kiss_primary_1875367 |
| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Chronic active hepatitis Liver cirrhosis Serum type IV collagen-7S domain |
| title | 만성활동성 간염과 간경변증 환자에서 혈청 4형 교원질의 의의 |
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