지속적 저용량 인슐린 /포도당 주입검사 ( LDIGIT , Low Dose Insulin and Glucose Infusion Test ) 를 이용한 인슐린 감수성의 측정

/A Background: Measurement of insulin sensitivity index by continuous low dose insulin and glucose infusion test(LDIGIT) has been reported to be simple and reliable. Methods: The method is a refinement of the modified Harano test and consisted of continuous low dose insulin(25mU/kghr) and glucose(4m...

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Veröffentlicht in:Diabetes & metabolism journal 1997-12, Vol.21 (4), p.425
Hauptverfasser: 송영득, Young Duk Song, 차봉수, Bong Soo Cha, 박석원, Suk Won Park, 원영준, Young Joon Won, 남수연, Soo Yeon nam, 임승길, Sung Kil Lim, 김경래, Kyung Rae Kim, 이현철, HC Lee, 허갑범, KB Huh
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container_issue 4
container_start_page 425
container_title Diabetes & metabolism journal
container_volume 21
creator 송영득
Young Duk Song
차봉수
Bong Soo Cha
박석원
Suk Won Park
원영준
Young Joon Won
남수연
Soo Yeon nam
임승길
Sung Kil Lim
김경래
Kyung Rae Kim
이현철
HC Lee
허갑범
KB Huh
description /A Background: Measurement of insulin sensitivity index by continuous low dose insulin and glucose infusion test(LDIGIT) has been reported to be simple and reliable. Methods: The method is a refinement of the modified Harano test and consisted of continuous low dose insulin(25mU/kghr) and glucose(4mg/kghr) infusion lasting 150 min. Insulin sensitivity was evaluated as the amount of glucose infusion divided by the steady state serum insulin and glucose levels achieved at the end of the test. Insulin secretion was expressed as the incremental area for C-peptide concentration during the first 15 min of the test. The indices of insulin sensitivity and insulin secretion yielded by LDIGIT were compared with those derived from the euglycemic clamp and oral glucose tolerance test (OGTT), respectively. Thirteen subjects underwent LDIGIT and euglycemic clamp. Results: LDIGIT resulted in stable final glucose levels but 3 subjects showed hypoglycemia during the test. The index of insulin secretion provided by LBIGIT did not correlate well with that of OGTT. There was a significant correlation between the ISI (insulin sensitivity index) determined by LDIGIT and the ISI determined by clamp(r=0.60, p
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Methods: The method is a refinement of the modified Harano test and consisted of continuous low dose insulin(25mU/kghr) and glucose(4mg/kghr) infusion lasting 150 min. Insulin sensitivity was evaluated as the amount of glucose infusion divided by the steady state serum insulin and glucose levels achieved at the end of the test. Insulin secretion was expressed as the incremental area for C-peptide concentration during the first 15 min of the test. The indices of insulin sensitivity and insulin secretion yielded by LDIGIT were compared with those derived from the euglycemic clamp and oral glucose tolerance test (OGTT), respectively. Thirteen subjects underwent LDIGIT and euglycemic clamp. Results: LDIGIT resulted in stable final glucose levels but 3 subjects showed hypoglycemia during the test. The index of insulin secretion provided by LBIGIT did not correlate well with that of OGTT. There was a significant correlation between the ISI (insulin sensitivity index) determined by LDIGIT and the ISI determined by clamp(r=0.60, p&lt;0.05). Conclusion: LDIGIT is a simple and accurate methcd to assess insulin sensitivity. It can be used in population studies and in situations when more complex technique is not feasible. However, it is desirable to reduce the insulin infusion rate to avoid the occurrence of hypoglycemia in Koreans.</description><identifier>ISSN: 2233-6079</identifier><language>kor</language><publisher>대한당뇨병학회</publisher><subject>Insulin sensitivity ; Low dose insulin and glucose infusion</subject><ispartof>Diabetes &amp; metabolism journal, 1997-12, Vol.21 (4), p.425</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>송영득</creatorcontrib><creatorcontrib>Young Duk Song</creatorcontrib><creatorcontrib>차봉수</creatorcontrib><creatorcontrib>Bong Soo Cha</creatorcontrib><creatorcontrib>박석원</creatorcontrib><creatorcontrib>Suk Won Park</creatorcontrib><creatorcontrib>원영준</creatorcontrib><creatorcontrib>Young Joon Won</creatorcontrib><creatorcontrib>남수연</creatorcontrib><creatorcontrib>Soo Yeon nam</creatorcontrib><creatorcontrib>임승길</creatorcontrib><creatorcontrib>Sung Kil Lim</creatorcontrib><creatorcontrib>김경래</creatorcontrib><creatorcontrib>Kyung Rae Kim</creatorcontrib><creatorcontrib>이현철</creatorcontrib><creatorcontrib>HC Lee</creatorcontrib><creatorcontrib>허갑범</creatorcontrib><creatorcontrib>KB Huh</creatorcontrib><title>지속적 저용량 인슐린 /포도당 주입검사 ( LDIGIT , Low Dose Insulin and Glucose Infusion Test ) 를 이용한 인슐린 감수성의 측정</title><title>Diabetes &amp; metabolism journal</title><addtitle>Diabetes and Metabolism Journal (DMJ)</addtitle><description>/A Background: Measurement of insulin sensitivity index by continuous low dose insulin and glucose infusion test(LDIGIT) has been reported to be simple and reliable. Methods: The method is a refinement of the modified Harano test and consisted of continuous low dose insulin(25mU/kghr) and glucose(4mg/kghr) infusion lasting 150 min. Insulin sensitivity was evaluated as the amount of glucose infusion divided by the steady state serum insulin and glucose levels achieved at the end of the test. Insulin secretion was expressed as the incremental area for C-peptide concentration during the first 15 min of the test. The indices of insulin sensitivity and insulin secretion yielded by LDIGIT were compared with those derived from the euglycemic clamp and oral glucose tolerance test (OGTT), respectively. Thirteen subjects underwent LDIGIT and euglycemic clamp. Results: LDIGIT resulted in stable final glucose levels but 3 subjects showed hypoglycemia during the test. The index of insulin secretion provided by LBIGIT did not correlate well with that of OGTT. There was a significant correlation between the ISI (insulin sensitivity index) determined by LDIGIT and the ISI determined by clamp(r=0.60, p&lt;0.05). Conclusion: LDIGIT is a simple and accurate methcd to assess insulin sensitivity. It can be used in population studies and in situations when more complex technique is not feasible. However, it is desirable to reduce the insulin infusion rate to avoid the occurrence of hypoglycemia in Koreans.</description><subject>Insulin sensitivity</subject><subject>Low dose insulin and glucose infusion</subject><issn>2233-6079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNpjYeA0MjI21jUzMLfkYOAtLs5MMjA0MzSwMDA35mSY-WZ5w5u23jcLGhXeLGh4M2vl6_mdCm_m7njTNeH1sg0K-m_717zub3ndvVPhzeI9b-a1vtrU8KZpjYKGgo-Lp7tniIKOgk9-uYJLfnGqgmdecWlOZp5CYl6KgntOaTJELK20ODM_TyEktbhEQVPh9dI9QNO3AO15O3UOkj2vNkx40zHjTcvGN3NnKLzZsfDNgqk8DKxpiTnFqbxQmptB2s01xNlDNzuzuDi-oCgzN7GoMt7QwszIxMLAGL8sAMjkbYY</recordid><startdate>19971230</startdate><enddate>19971230</enddate><creator>송영득</creator><creator>Young Duk Song</creator><creator>차봉수</creator><creator>Bong Soo Cha</creator><creator>박석원</creator><creator>Suk Won Park</creator><creator>원영준</creator><creator>Young Joon Won</creator><creator>남수연</creator><creator>Soo Yeon nam</creator><creator>임승길</creator><creator>Sung Kil Lim</creator><creator>김경래</creator><creator>Kyung Rae Kim</creator><creator>이현철</creator><creator>HC Lee</creator><creator>허갑범</creator><creator>KB Huh</creator><general>대한당뇨병학회</general><scope>HZB</scope><scope>Q5X</scope></search><sort><creationdate>19971230</creationdate><title>지속적 저용량 인슐린 /포도당 주입검사 ( LDIGIT , Low Dose Insulin and Glucose Infusion Test ) 를 이용한 인슐린 감수성의 측정</title><author>송영득 ; Young Duk Song ; 차봉수 ; Bong Soo Cha ; 박석원 ; Suk Won Park ; 원영준 ; Young Joon Won ; 남수연 ; Soo Yeon nam ; 임승길 ; Sung Kil Lim ; 김경래 ; Kyung Rae Kim ; 이현철 ; HC Lee ; 허갑범 ; KB Huh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kiss_primary_18624803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>1997</creationdate><topic>Insulin sensitivity</topic><topic>Low dose insulin and glucose infusion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>송영득</creatorcontrib><creatorcontrib>Young Duk Song</creatorcontrib><creatorcontrib>차봉수</creatorcontrib><creatorcontrib>Bong Soo Cha</creatorcontrib><creatorcontrib>박석원</creatorcontrib><creatorcontrib>Suk Won Park</creatorcontrib><creatorcontrib>원영준</creatorcontrib><creatorcontrib>Young Joon Won</creatorcontrib><creatorcontrib>남수연</creatorcontrib><creatorcontrib>Soo Yeon nam</creatorcontrib><creatorcontrib>임승길</creatorcontrib><creatorcontrib>Sung Kil Lim</creatorcontrib><creatorcontrib>김경래</creatorcontrib><creatorcontrib>Kyung Rae Kim</creatorcontrib><creatorcontrib>이현철</creatorcontrib><creatorcontrib>HC Lee</creatorcontrib><creatorcontrib>허갑범</creatorcontrib><creatorcontrib>KB Huh</creatorcontrib><collection>Korean Studies Information Service System (KISS)</collection><collection>Korean Studies Information Service System (KISS) B-Type</collection><jtitle>Diabetes &amp; metabolism journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>송영득</au><au>Young Duk Song</au><au>차봉수</au><au>Bong Soo Cha</au><au>박석원</au><au>Suk Won Park</au><au>원영준</au><au>Young Joon Won</au><au>남수연</au><au>Soo Yeon nam</au><au>임승길</au><au>Sung Kil Lim</au><au>김경래</au><au>Kyung Rae Kim</au><au>이현철</au><au>HC Lee</au><au>허갑범</au><au>KB Huh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>지속적 저용량 인슐린 /포도당 주입검사 ( LDIGIT , Low Dose Insulin and Glucose Infusion Test ) 를 이용한 인슐린 감수성의 측정</atitle><jtitle>Diabetes &amp; metabolism journal</jtitle><addtitle>Diabetes and Metabolism Journal (DMJ)</addtitle><date>1997-12-30</date><risdate>1997</risdate><volume>21</volume><issue>4</issue><spage>425</spage><pages>425-</pages><issn>2233-6079</issn><abstract>/A Background: Measurement of insulin sensitivity index by continuous low dose insulin and glucose infusion test(LDIGIT) has been reported to be simple and reliable. Methods: The method is a refinement of the modified Harano test and consisted of continuous low dose insulin(25mU/kghr) and glucose(4mg/kghr) infusion lasting 150 min. Insulin sensitivity was evaluated as the amount of glucose infusion divided by the steady state serum insulin and glucose levels achieved at the end of the test. Insulin secretion was expressed as the incremental area for C-peptide concentration during the first 15 min of the test. The indices of insulin sensitivity and insulin secretion yielded by LDIGIT were compared with those derived from the euglycemic clamp and oral glucose tolerance test (OGTT), respectively. Thirteen subjects underwent LDIGIT and euglycemic clamp. Results: LDIGIT resulted in stable final glucose levels but 3 subjects showed hypoglycemia during the test. The index of insulin secretion provided by LBIGIT did not correlate well with that of OGTT. There was a significant correlation between the ISI (insulin sensitivity index) determined by LDIGIT and the ISI determined by clamp(r=0.60, p&lt;0.05). Conclusion: LDIGIT is a simple and accurate methcd to assess insulin sensitivity. It can be used in population studies and in situations when more complex technique is not feasible. However, it is desirable to reduce the insulin infusion rate to avoid the occurrence of hypoglycemia in Koreans.</abstract><pub>대한당뇨병학회</pub><tpages>8</tpages></addata></record>
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subjects Insulin sensitivity
Low dose insulin and glucose infusion
title 지속적 저용량 인슐린 /포도당 주입검사 ( LDIGIT , Low Dose Insulin and Glucose Infusion Test ) 를 이용한 인슐린 감수성의 측정
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