Endogenous Phospholipid Metabolite Containing Topical Product Inhibits Ultraviolet Light-Induced Inflammation and DNA Damage in Human Skin

Background: N-palmitoylethanolamine (PEA) and organic osmolytes are endogenous components of the human epidermis and are generated from phospholipids in the stratum granulosum. PEA has been shown to exert potent antioxidant and anti-inflammatory activities. The endogenous organic osmolytes such as b...

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Veröffentlicht in:	Skin pharmacology and physiology 2007-01, Vol.20 (3), p.155-161
Hauptverfasser:	Kemeny, L., Koreck, A., Kis, K., Kenderessy-Szabo, A., Bodai, L., Cimpean, A., Paunescu, V., Raica, M., Ghyczy, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Adult Betaine - administration & dosage Betaine - chemistry Betaine - therapeutic use Chemistry, Pharmaceutical DNA - drug effects DNA - radiation effects DNA Damage Dose-Response Relationship, Radiation Drug Combinations Endocannabinoids Erythema - etiology Erythema - metabolism Erythema - prevention & control Ethanolamines Gels Humans Original Paper Palmitic Acids - administration & dosage Palmitic Acids - chemistry Palmitic Acids - therapeutic use Pyrimidine Dimers - metabolism Radiodermatitis - etiology Radiodermatitis - metabolism Radiodermatitis - prevention & control Sarcosine - administration & dosage Sarcosine - chemistry Sarcosine - therapeutic use Skin - drug effects Skin - metabolism Skin - radiation effects Sunscreening Agents - administration & dosage Sunscreening Agents - chemistry Sunscreening Agents - therapeutic use Treatment Outcome Ultraviolet Rays - adverse effects
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