Detection of Melanoma Relapse: First Comparative Analysis on Imaging Techniques versus S100 Protein
Background: Early detection of melanoma recurrence is essential for the patient’s prognosis. The serum S100 level may be a useful tool to detect relapse early. Objective: To compare the efficacy of imaging techniques and serum S100 in the early detection of melanoma progression. This is the first re...
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| Veröffentlicht in: | Dermatology (Basel) 2006-01, Vol.213 (3), p.187-191 |
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| creator | Beyeler, Mirjam Waldispühl, Severa Strobel, Klaus Joller-Jemelka, Helen I. Burg, Günter Dummer, Reinhard |
| description | Background: Early detection of melanoma recurrence is essential for the patient’s prognosis. The serum S100 level may be a useful tool to detect relapse early. Objective: To compare the efficacy of imaging techniques and serum S100 in the early detection of melanoma progression. This is the first report of a comparison of a serum marker with an imaging tool in the follow-up of melanoma patients. Methods: From 1992 to 2003, we screened 192 patients suffering from melanoma recurrence after a disease-free interval. Of those, 127 patients were identified whose S100 levels had been assessed parallel to imaging procedures. Results: Serum S100 was elevated in 37% of patients at the time of relapse. In stage III, 32% of the patients had elevated S100 levels whereas in case of progression to stage IV, 48% of the patients presented with increased S100. In 5.5% of patients, S100 was the first indicator of disease progression. Imaging procedures lead to detection of melanoma recurrence in 26.8%. Conclusion: A rising level of serum S100 is a specific and sensitive marker of melanoma progression. |
| doi_str_mv | 10.1159/000095034 |
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The serum S100 level may be a useful tool to detect relapse early. Objective: To compare the efficacy of imaging techniques and serum S100 in the early detection of melanoma progression. This is the first report of a comparison of a serum marker with an imaging tool in the follow-up of melanoma patients. Methods: From 1992 to 2003, we screened 192 patients suffering from melanoma recurrence after a disease-free interval. Of those, 127 patients were identified whose S100 levels had been assessed parallel to imaging procedures. Results: Serum S100 was elevated in 37% of patients at the time of relapse. In stage III, 32% of the patients had elevated S100 levels whereas in case of progression to stage IV, 48% of the patients presented with increased S100. In 5.5% of patients, S100 was the first indicator of disease progression. Imaging procedures lead to detection of melanoma recurrence in 26.8%. Conclusion: A rising level of serum S100 is a specific and sensitive marker of melanoma progression.</description><identifier>ISSN: 1018-8665</identifier><identifier>EISSN: 1421-9832</identifier><identifier>DOI: 10.1159/000095034</identifier><identifier>PMID: 17033166</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Aged ; Biological and medical sciences ; Biomarkers, Tumor - blood ; Clinical and Laboratory Investigations ; Comparative analysis ; Dermatology ; Diagnosis, Differential ; Disease Progression ; Female ; Humans ; Lymphatic Metastasis - diagnosis ; Magnetic Resonance Imaging ; Male ; Medical imaging ; Medical sciences ; Medical screening ; Melanoma - blood ; Melanoma - diagnosis ; Melanoma - pathology ; Middle Aged ; Neoplasm Recurrence, Local - blood ; Neoplasm Recurrence, Local - diagnosis ; Positron-Emission Tomography ; Predictive Value of Tests ; Proteins ; S100 Proteins - blood ; Sensitivity and Specificity ; Skin cancer ; Skin Neoplasms - blood ; Skin Neoplasms - diagnosis ; Skin Neoplasms - pathology ; Tomography, X-Ray Computed ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Dermatology (Basel), 2006-01, Vol.213 (3), p.187-191</ispartof><rights>2006 S. Karger AG, Basel</rights><rights>2006 INIST-CNRS</rights><rights>Copyright (c) 2006 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-3114d25db96fc6b06b10001d6bab92288419726741a90348c8c7ae9f4bae06dd3</citedby><cites>FETCH-LOGICAL-c360t-3114d25db96fc6b06b10001d6bab92288419726741a90348c8c7ae9f4bae06dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18245736$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17033166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beyeler, Mirjam</creatorcontrib><creatorcontrib>Waldispühl, Severa</creatorcontrib><creatorcontrib>Strobel, Klaus</creatorcontrib><creatorcontrib>Joller-Jemelka, Helen I.</creatorcontrib><creatorcontrib>Burg, Günter</creatorcontrib><creatorcontrib>Dummer, Reinhard</creatorcontrib><title>Detection of Melanoma Relapse: First Comparative Analysis on Imaging Techniques versus S100 Protein</title><title>Dermatology (Basel)</title><addtitle>Dermatology</addtitle><description>Background: Early detection of melanoma recurrence is essential for the patient’s prognosis. The serum S100 level may be a useful tool to detect relapse early. Objective: To compare the efficacy of imaging techniques and serum S100 in the early detection of melanoma progression. This is the first report of a comparison of a serum marker with an imaging tool in the follow-up of melanoma patients. Methods: From 1992 to 2003, we screened 192 patients suffering from melanoma recurrence after a disease-free interval. Of those, 127 patients were identified whose S100 levels had been assessed parallel to imaging procedures. Results: Serum S100 was elevated in 37% of patients at the time of relapse. In stage III, 32% of the patients had elevated S100 levels whereas in case of progression to stage IV, 48% of the patients presented with increased S100. In 5.5% of patients, S100 was the first indicator of disease progression. Imaging procedures lead to detection of melanoma recurrence in 26.8%. Conclusion: A rising level of serum S100 is a specific and sensitive marker of melanoma progression.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - blood</subject><subject>Clinical and Laboratory Investigations</subject><subject>Comparative analysis</subject><subject>Dermatology</subject><subject>Diagnosis, Differential</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphatic Metastasis - diagnosis</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical sciences</subject><subject>Medical screening</subject><subject>Melanoma - blood</subject><subject>Melanoma - diagnosis</subject><subject>Melanoma - pathology</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - blood</subject><subject>Neoplasm Recurrence, Local - diagnosis</subject><subject>Positron-Emission Tomography</subject><subject>Predictive Value of Tests</subject><subject>Proteins</subject><subject>S100 Proteins - blood</subject><subject>Sensitivity and Specificity</subject><subject>Skin cancer</subject><subject>Skin Neoplasms - blood</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - pathology</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumors of the skin and soft tissue. 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Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beyeler, Mirjam</creatorcontrib><creatorcontrib>Waldispühl, Severa</creatorcontrib><creatorcontrib>Strobel, Klaus</creatorcontrib><creatorcontrib>Joller-Jemelka, Helen I.</creatorcontrib><creatorcontrib>Burg, Günter</creatorcontrib><creatorcontrib>Dummer, Reinhard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatology (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beyeler, Mirjam</au><au>Waldispühl, Severa</au><au>Strobel, Klaus</au><au>Joller-Jemelka, Helen I.</au><au>Burg, Günter</au><au>Dummer, Reinhard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of Melanoma Relapse: First Comparative Analysis on Imaging Techniques versus S100 Protein</atitle><jtitle>Dermatology (Basel)</jtitle><addtitle>Dermatology</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>213</volume><issue>3</issue><spage>187</spage><epage>191</epage><pages>187-191</pages><issn>1018-8665</issn><eissn>1421-9832</eissn><abstract>Background: Early detection of melanoma recurrence is essential for the patient’s prognosis. The serum S100 level may be a useful tool to detect relapse early. Objective: To compare the efficacy of imaging techniques and serum S100 in the early detection of melanoma progression. This is the first report of a comparison of a serum marker with an imaging tool in the follow-up of melanoma patients. Methods: From 1992 to 2003, we screened 192 patients suffering from melanoma recurrence after a disease-free interval. Of those, 127 patients were identified whose S100 levels had been assessed parallel to imaging procedures. Results: Serum S100 was elevated in 37% of patients at the time of relapse. In stage III, 32% of the patients had elevated S100 levels whereas in case of progression to stage IV, 48% of the patients presented with increased S100. In 5.5% of patients, S100 was the first indicator of disease progression. Imaging procedures lead to detection of melanoma recurrence in 26.8%. Conclusion: A rising level of serum S100 is a specific and sensitive marker of melanoma progression.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>17033166</pmid><doi>10.1159/000095034</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Biological and medical sciences Biomarkers, Tumor - blood Clinical and Laboratory Investigations Comparative analysis Dermatology Diagnosis, Differential Disease Progression Female Humans Lymphatic Metastasis - diagnosis Magnetic Resonance Imaging Male Medical imaging Medical sciences Medical screening Melanoma - blood Melanoma - diagnosis Melanoma - pathology Middle Aged Neoplasm Recurrence, Local - blood Neoplasm Recurrence, Local - diagnosis Positron-Emission Tomography Predictive Value of Tests Proteins S100 Proteins - blood Sensitivity and Specificity Skin cancer Skin Neoplasms - blood Skin Neoplasms - diagnosis Skin Neoplasms - pathology Tomography, X-Ray Computed Tumors of the skin and soft tissue. Premalignant lesions |
| title | Detection of Melanoma Relapse: First Comparative Analysis on Imaging Techniques versus S100 Protein |
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