Expression of the High-Affinity Fluoropyrimidine-Preferring Nucleoside Transporter hCNT1 Correlates with Decreased Disease-Free Survival in Breast Cancer

Purpose: Nucleoside and nucleobase derivatives are currently used in the treatment of a variety of solid tumors; however, the role of plasma membrane transporters as biomarkers of drug metabolism has not been fully addressed. Thus, the purpose of this study was to determine whether the concentrative...

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Veröffentlicht in:	Oncology 2006-01, Vol.70 (3), p.238-244
Hauptverfasser:	Gloeckner-Hofmann, Katharina, Guillén-Gómez, Elena, Schmidtgen, Claudia, Porstmann, Romy, Ziegler, Ralf, Stoss, Oliver, Casado, F. Javier, Rüschoff, Josef, Pastor-Anglada, Marçal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Breast Neoplasms - surgery Chemotherapy, Adjuvant Correlation analysis Cyclophosphamide - administration & dosage Disease-Free Survival Female Fluorouracil - administration & dosage Gene expression Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Laboratory Investigation Mammary gland diseases Medical sciences Membrane Transport Proteins - metabolism Methotrexate - administration & dosage Middle Aged Oncology Predictive Value of Tests Prognosis Survivor Tumors
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