Stereological Evaluation of the Seminiferous Tubules of Rats after Maternal Undernutrition during the Lactation Period
The goal of this study is to evaluate, through stereological methods, some structural aspects of offspring testes whose dams were submitted to protein and energy-restricted diets during the lactation period. At birth, dams were separated into 3 groups: control group (C), receiving a diet with 23% pr...
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Veröffentlicht in: | Urologia internationalis 2006-01, Vol.76 (1), p.63-66 |
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description | The goal of this study is to evaluate, through stereological methods, some structural aspects of offspring testes whose dams were submitted to protein and energy-restricted diets during the lactation period. At birth, dams were separated into 3 groups: control group (C), receiving a diet with 23% protein; protein-restricted group (PR), receiving a diet with 8% protein; energy-restricted group (ER), receiving a diet with 23% protein in restricted quantities. At weaning, the offspring was anesthetized and perfused with formalin solution. Then, the testes were excised and processed using routine histological methods. Compared to the C group, both PR and ER groups had a significant reduction in the testis weight (PR = 65%, ER = 60%, p < 0.01), in the total area (PR = 23%, ER = 32%, p < 0.01), in the luminal area (PR = 30%, ER = 36%, p < 0.01), in the epithelial area (PR = 21%, ER = 27%, p < 0.01), and in the epithelial height (PR = 17%, ER = 23%, p < 0.01) of the seminiferous tubule. We conclude that maternal malnutrition during lactation leads to structural changes in the testis that could be responsible for future alterations in this organ physiology. |
doi_str_mv | 10.1159/000089737 |
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At birth, dams were separated into 3 groups: control group (C), receiving a diet with 23% protein; protein-restricted group (PR), receiving a diet with 8% protein; energy-restricted group (ER), receiving a diet with 23% protein in restricted quantities. At weaning, the offspring was anesthetized and perfused with formalin solution. Then, the testes were excised and processed using routine histological methods. Compared to the C group, both PR and ER groups had a significant reduction in the testis weight (PR = 65%, ER = 60%, p < 0.01), in the total area (PR = 23%, ER = 32%, p < 0.01), in the luminal area (PR = 30%, ER = 36%, p < 0.01), in the epithelial area (PR = 21%, ER = 27%, p < 0.01), and in the epithelial height (PR = 17%, ER = 23%, p < 0.01) of the seminiferous tubule. We conclude that maternal malnutrition during lactation leads to structural changes in the testis that could be responsible for future alterations in this organ physiology.</description><identifier>ISSN: 0042-1138</identifier><identifier>EISSN: 1423-0399</identifier><identifier>DOI: 10.1159/000089737</identifier><identifier>PMID: 16401923</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Animal Nutritional Physiological Phenomena ; Animals ; Animals, Newborn ; Lactation ; Male ; Maternal Nutritional Physiological Phenomena ; Organ Size ; Original Paper ; Protein-Energy Malnutrition ; Rats ; Rats, Wistar ; Seminiferous Tubules - pathology ; Testis - pathology</subject><ispartof>Urologia internationalis, 2006-01, Vol.76 (1), p.63-66</ispartof><rights>2006 S. Karger AG, Basel</rights><rights>Copyright (c) 2006 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c303t-5f6a5394a5399d2af583517976088290f50e7708464a106937dd139157b1a1c73</citedby><cites>FETCH-LOGICAL-c303t-5f6a5394a5399d2af583517976088290f50e7708464a106937dd139157b1a1c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2428,4023,27922,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16401923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramos, Cristiane da Fonte</creatorcontrib><creatorcontrib>da Silva, Alexandra Moreira</creatorcontrib><creatorcontrib>Costa, Waldemar Silva</creatorcontrib><creatorcontrib>Sampaio, Francisco J.B.</creatorcontrib><title>Stereological Evaluation of the Seminiferous Tubules of Rats after Maternal Undernutrition during the Lactation Period</title><title>Urologia internationalis</title><addtitle>Urol Int</addtitle><description>The goal of this study is to evaluate, through stereological methods, some structural aspects of offspring testes whose dams were submitted to protein and energy-restricted diets during the lactation period. At birth, dams were separated into 3 groups: control group (C), receiving a diet with 23% protein; protein-restricted group (PR), receiving a diet with 8% protein; energy-restricted group (ER), receiving a diet with 23% protein in restricted quantities. At weaning, the offspring was anesthetized and perfused with formalin solution. Then, the testes were excised and processed using routine histological methods. Compared to the C group, both PR and ER groups had a significant reduction in the testis weight (PR = 65%, ER = 60%, p < 0.01), in the total area (PR = 23%, ER = 32%, p < 0.01), in the luminal area (PR = 30%, ER = 36%, p < 0.01), in the epithelial area (PR = 21%, ER = 27%, p < 0.01), and in the epithelial height (PR = 17%, ER = 23%, p < 0.01) of the seminiferous tubule. We conclude that maternal malnutrition during lactation leads to structural changes in the testis that could be responsible for future alterations in this organ physiology.</description><subject>Animal Nutritional Physiological Phenomena</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Lactation</subject><subject>Male</subject><subject>Maternal Nutritional Physiological Phenomena</subject><subject>Organ Size</subject><subject>Original Paper</subject><subject>Protein-Energy Malnutrition</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Seminiferous Tubules - pathology</subject><subject>Testis - pathology</subject><issn>0042-1138</issn><issn>1423-0399</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LwzAYh4Mobk4PngXpSfBQTZomaY4y5gdMFLedS9YmM9o2Mx8D_3uzdcwc3gTy_B54fwBcIniHEOH3MJ6CM8yOwBDlGU4h5vwYDCHMsxQhXAzAmXNfEEaYs1MwQDSHiGd4CDYzL600jVnpSjTJZCOaILw2XWJU4j9lMpOt7rSS1gSXzMMyNNJt_z6Ed4lQMZ28iji7mF50dXwEb_XOUAeru9XOMhWV77Xv0mpTn4MTJRonL_b3CCweJ_Pxczp9e3oZP0zTCkPsU6KoIJjn28HrTChSYIIYZxQWRcahIlAyBouc5gJByjGra4Q5ImyJBKoYHoGb3ru25idI58tWu0o2jehkXKikjCIKSR7B2x6srHHOSlWurW6F_S0RLLcll4eSI3u9l4ZlK-t_ct9qBK564FvYlbQHoI__AeRef7s</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>Ramos, Cristiane da Fonte</creator><creator>da Silva, Alexandra Moreira</creator><creator>Costa, Waldemar Silva</creator><creator>Sampaio, Francisco J.B.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200601</creationdate><title>Stereological Evaluation of the Seminiferous Tubules of Rats after Maternal Undernutrition during the Lactation Period</title><author>Ramos, Cristiane da Fonte ; da Silva, Alexandra Moreira ; Costa, Waldemar Silva ; Sampaio, Francisco J.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-5f6a5394a5399d2af583517976088290f50e7708464a106937dd139157b1a1c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animal Nutritional Physiological Phenomena</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Lactation</topic><topic>Male</topic><topic>Maternal Nutritional Physiological Phenomena</topic><topic>Organ Size</topic><topic>Original Paper</topic><topic>Protein-Energy Malnutrition</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Seminiferous Tubules - pathology</topic><topic>Testis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramos, Cristiane da Fonte</creatorcontrib><creatorcontrib>da Silva, Alexandra Moreira</creatorcontrib><creatorcontrib>Costa, Waldemar Silva</creatorcontrib><creatorcontrib>Sampaio, Francisco J.B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Urologia internationalis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramos, Cristiane da Fonte</au><au>da Silva, Alexandra Moreira</au><au>Costa, Waldemar Silva</au><au>Sampaio, Francisco J.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stereological Evaluation of the Seminiferous Tubules of Rats after Maternal Undernutrition during the Lactation Period</atitle><jtitle>Urologia internationalis</jtitle><addtitle>Urol Int</addtitle><date>2006-01</date><risdate>2006</risdate><volume>76</volume><issue>1</issue><spage>63</spage><epage>66</epage><pages>63-66</pages><issn>0042-1138</issn><eissn>1423-0399</eissn><abstract>The goal of this study is to evaluate, through stereological methods, some structural aspects of offspring testes whose dams were submitted to protein and energy-restricted diets during the lactation period. At birth, dams were separated into 3 groups: control group (C), receiving a diet with 23% protein; protein-restricted group (PR), receiving a diet with 8% protein; energy-restricted group (ER), receiving a diet with 23% protein in restricted quantities. At weaning, the offspring was anesthetized and perfused with formalin solution. Then, the testes were excised and processed using routine histological methods. Compared to the C group, both PR and ER groups had a significant reduction in the testis weight (PR = 65%, ER = 60%, p < 0.01), in the total area (PR = 23%, ER = 32%, p < 0.01), in the luminal area (PR = 30%, ER = 36%, p < 0.01), in the epithelial area (PR = 21%, ER = 27%, p < 0.01), and in the epithelial height (PR = 17%, ER = 23%, p < 0.01) of the seminiferous tubule. We conclude that maternal malnutrition during lactation leads to structural changes in the testis that could be responsible for future alterations in this organ physiology.</abstract><cop>Basel, Switzerland</cop><pmid>16401923</pmid><doi>10.1159/000089737</doi><tpages>4</tpages></addata></record> |
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subjects | Animal Nutritional Physiological Phenomena Animals Animals, Newborn Lactation Male Maternal Nutritional Physiological Phenomena Organ Size Original Paper Protein-Energy Malnutrition Rats Rats, Wistar Seminiferous Tubules - pathology Testis - pathology |
title | Stereological Evaluation of the Seminiferous Tubules of Rats after Maternal Undernutrition during the Lactation Period |
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