A molecular cytogenetic study of chromosome evolution in chimpanzee
We applied multitude multicolor banding (mMCB) in combination with a novel FISH DNA probe set including subcentromeric, subtelomeric and whole chromosome painting probes (subCTM) to characterize a Pan paniscus (PPA) cell line. These powerful techniques allowed us to refine the breakpoints of a peric...
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| Veröffentlicht in: | Cytogenetic and genome research 2006-01, Vol.112 (1-2), p.67-75 |
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| container_title | Cytogenetic and genome research |
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| creator | Gross, M. Starke, H. Trifonov, V. Claussen, U. Liehr, T. Weise, A. |
| description | We applied multitude multicolor banding (mMCB) in combination with a novel FISH DNA probe set including subcentromeric, subtelomeric and whole chromosome painting probes (subCTM) to characterize a Pan paniscus (PPA) cell line. These powerful techniques allowed us to refine the breakpoints of a pericentric inversion on chimpanzee chromosome 4, and discovered a novel cryptic pericentric inversion in chimpanzee chromosome 11. mMCB provided a starting point for mapping and high resolution analysis of breakpoints on PPA chromosome 4, which are within a long terminal repeat (LTR) and surrounded by segmental duplications, as well as the integration/expansion sites of the interstitial heterochromatin on chimpanzee chromosomes 6 and 14. Moreover, we found evidence at hand for different types of heterochromatin in the chimpanzee genome. Finally, shedding new light on the human/chimpanzee speciation, karyotypes of three members of the genus Pan were studied by mMCB and no cytogenetic differences were found although the phylogenetic distance between these subspecies is suggested to be 2.5 million years. |
| doi_str_mv | 10.1159/000087515 |
| format | Article |
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These powerful techniques allowed us to refine the breakpoints of a pericentric inversion on chimpanzee chromosome 4, and discovered a novel cryptic pericentric inversion in chimpanzee chromosome 11. mMCB provided a starting point for mapping and high resolution analysis of breakpoints on PPA chromosome 4, which are within a long terminal repeat (LTR) and surrounded by segmental duplications, as well as the integration/expansion sites of the interstitial heterochromatin on chimpanzee chromosomes 6 and 14. Moreover, we found evidence at hand for different types of heterochromatin in the chimpanzee genome. 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| subjects | Animals Cell Line Cells, Cultured Chromosome Mapping Chromosomes, Artificial, Bacterial Chromosomes, Mammalian - genetics Cytogenetics - methods Evolution, Molecular Female Humans In Situ Hybridization, Fluorescence Male Original Article Pan paniscus Pan troglodytes Pan troglodytes - genetics Phylogeny |
| title | A molecular cytogenetic study of chromosome evolution in chimpanzee |
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