Epithelial Defence by γδ T Cells
γδ T cells constitute a separate lineage of T lymphocytes which differ from conventional αβ T cells with regard to T cell receptor (TCR) repertoire and tissue localization. In murine skin, γδ T cells expressing a canonical Vγ5 TCR are abundant and contribute as so-called dendritic epidermal T cells...
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| Veröffentlicht in: | International archives of allergy and immunology 2005-01, Vol.137 (1), p.73-81 |
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| container_issue | 1 |
| container_start_page | 73 |
| container_title | International archives of allergy and immunology |
| container_volume | 137 |
| creator | Kabelitz, Dieter Marischen, Lothar Oberg, Hans-Heinrich Holtmeier, Wolfgang Wesch, Daniela |
| description | γδ T cells constitute a separate lineage of T lymphocytes which differ from conventional αβ T cells with regard to T cell receptor (TCR) repertoire and tissue localization. In murine skin, γδ T cells expressing a canonical Vγ5 TCR are abundant and contribute as so-called dendritic epidermal T cells to local immune surveillance. In humans, major subsets of γδ T cells are recognized on the basis of their TCR Vδ usage. While Vδ2 cells dominate in the peripheral blood, Vδ1 cells are preferentially localized in mucosal tissue including the intestinal epithelia. In this article we summarize basic features of intraepithelial γδ T cells and discuss their possible role in epithelial defence. |
| doi_str_mv | 10.1159/000085107 |
| format | Article |
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In murine skin, γδ T cells expressing a canonical Vγ5 TCR are abundant and contribute as so-called dendritic epidermal T cells to local immune surveillance. In humans, major subsets of γδ T cells are recognized on the basis of their TCR Vδ usage. While Vδ2 cells dominate in the peripheral blood, Vδ1 cells are preferentially localized in mucosal tissue including the intestinal epithelia. In this article we summarize basic features of intraepithelial γδ T cells and discuss their possible role in epithelial defence.</description><identifier>ISSN: 1018-2438</identifier><identifier>EISSN: 1423-0097</identifier><identifier>DOI: 10.1159/000085107</identifier><identifier>PMID: 15832053</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Biological and medical sciences ; Fundamental and applied biological sciences. 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Psychology</topic><topic>Fundamental immunology</topic><topic>Immunopathology</topic><topic>Medical sciences</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kabelitz, Dieter</creatorcontrib><creatorcontrib>Marischen, Lothar</creatorcontrib><creatorcontrib>Oberg, Hans-Heinrich</creatorcontrib><creatorcontrib>Holtmeier, Wolfgang</creatorcontrib><creatorcontrib>Wesch, Daniela</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>International archives of allergy and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kabelitz, Dieter</au><au>Marischen, Lothar</au><au>Oberg, Hans-Heinrich</au><au>Holtmeier, Wolfgang</au><au>Wesch, Daniela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epithelial Defence by γδ T Cells</atitle><jtitle>International archives of allergy and immunology</jtitle><addtitle>Int Arch Allergy Immunol</addtitle><date>2005-01</date><risdate>2005</risdate><volume>137</volume><issue>1</issue><spage>73</spage><epage>81</epage><pages>73-81</pages><issn>1018-2438</issn><eissn>1423-0097</eissn><abstract>γδ T cells constitute a separate lineage of T lymphocytes which differ from conventional αβ T cells with regard to T cell receptor (TCR) repertoire and tissue localization. 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| identifier | ISSN: 1018-2438 |
| ispartof | International archives of allergy and immunology, 2005-01, Vol.137 (1), p.73-81 |
| issn | 1018-2438 1423-0097 |
| language | eng |
| recordid | cdi_karger_primary_85107 |
| source | Karger Journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Immunopathology Medical sciences Review |
| title | Epithelial Defence by γδ T Cells |
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