Serum Alpha- and Gamma-Tocopherol Levels in Atopic Mothers and Their Infants Are Correlated
Background: Vitamin E may have immunomodulatory properties beyond its antioxidant function. The objective here was to assess the α- and γ-tocopherol status and its correlation between atopic mothers and their infants. Methods: Mothers with atopic disease were recruited at the end of gestation and th...
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| Veröffentlicht in: | Biology of the neonate 2005-01, Vol.88 (1), p.24-26 |
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| creator | Hoppu, Ulla Salo-Väänänen, Pirjo Lampi, Anna-Maija Isolauri, Erika |
| description | Background: Vitamin E may have immunomodulatory properties beyond its antioxidant function. The objective here was to assess the α- and γ-tocopherol status and its correlation between atopic mothers and their infants. Methods: Mothers with atopic disease were recruited at the end of gestation and their infants were followed up. Serum samples from mothers and infants were collected at the infants’ age of 1 month. Atopic dermatitis was diagnosed during the 1st year of life and skin prick tests were performed at 1 year. Results: Infants’ serum γ- and α-tocopherol to fat ratios were significantly correlated with maternal serum ratios (r = 0.70, p < 0.0001 and r = 0.52, p = 0.004, respectively). In infants the serum α-tocopherol/fat was higher and the γ-tocopherol/fat ratio lower than in mothers. Serum tocopherol levels were not associated with skin prick test reactions or atopic dermatitis in the infants. Conclusions: Maternal tocopherol status determines that of the infant. Different tocopherol forms may have different serum levels and roles in the regulation of inflammatory diseases. |
| doi_str_mv | 10.1159/000084068 |
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The objective here was to assess the α- and γ-tocopherol status and its correlation between atopic mothers and their infants. Methods: Mothers with atopic disease were recruited at the end of gestation and their infants were followed up. Serum samples from mothers and infants were collected at the infants’ age of 1 month. Atopic dermatitis was diagnosed during the 1st year of life and skin prick tests were performed at 1 year. Results: Infants’ serum γ- and α-tocopherol to fat ratios were significantly correlated with maternal serum ratios (r = 0.70, p < 0.0001 and r = 0.52, p = 0.004, respectively). In infants the serum α-tocopherol/fat was higher and the γ-tocopherol/fat ratio lower than in mothers. Serum tocopherol levels were not associated with skin prick test reactions or atopic dermatitis in the infants. Conclusions: Maternal tocopherol status determines that of the infant. Different tocopherol forms may have different serum levels and roles in the regulation of inflammatory diseases.</description><identifier>ISSN: 1661-7800</identifier><identifier>ISSN: 0006-3126</identifier><identifier>EISSN: 1661-7819</identifier><identifier>EISSN: 1421-9727</identifier><identifier>DOI: 10.1159/000084068</identifier><identifier>PMID: 15731552</identifier><identifier>CODEN: BNEOBV</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; alpha-Tocopherol - blood ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antioxidants - metabolism ; Asthma - blood ; Asthma - immunology ; Biological and medical sciences ; Delivery. Postpartum. Lactation ; Dermatitis, Atopic - blood ; Dermatitis, Atopic - immunology ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Female ; gamma-Tocopherol - blood ; Gynecology. Andrology. Obstetrics ; Humans ; Hypersensitivity, Immediate - blood ; Hypersensitivity, Immediate - immunology ; Infant ; Intensive care medicine ; Medical sciences ; Mothers ; Original Paper ; Rhinitis, Allergic, Perennial - blood ; Rhinitis, Allergic, Perennial - immunology ; Skin Tests ; Statistics, Nonparametric</subject><ispartof>Biology of the neonate, 2005-01, Vol.88 (1), p.24-26</ispartof><rights>2005 S. Karger AG, Basel</rights><rights>2005 INIST-CNRS</rights><rights>Copyright (c) 2005 S. Karger AG, Basel.</rights><rights>Copyright (c) 2005 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-1ee0bc3a2c450da4b272a99494c16c3db9b5a23db7b363af00f12239e0be95083</citedby><cites>FETCH-LOGICAL-c360t-1ee0bc3a2c450da4b272a99494c16c3db9b5a23db7b363af00f12239e0be95083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16914917$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15731552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoppu, Ulla</creatorcontrib><creatorcontrib>Salo-Väänänen, Pirjo</creatorcontrib><creatorcontrib>Lampi, Anna-Maija</creatorcontrib><creatorcontrib>Isolauri, Erika</creatorcontrib><title>Serum Alpha- and Gamma-Tocopherol Levels in Atopic Mothers and Their Infants Are Correlated</title><title>Biology of the neonate</title><addtitle>Neonatology</addtitle><description>Background: Vitamin E may have immunomodulatory properties beyond its antioxidant function. The objective here was to assess the α- and γ-tocopherol status and its correlation between atopic mothers and their infants. Methods: Mothers with atopic disease were recruited at the end of gestation and their infants were followed up. Serum samples from mothers and infants were collected at the infants’ age of 1 month. Atopic dermatitis was diagnosed during the 1st year of life and skin prick tests were performed at 1 year. Results: Infants’ serum γ- and α-tocopherol to fat ratios were significantly correlated with maternal serum ratios (r = 0.70, p < 0.0001 and r = 0.52, p = 0.004, respectively). In infants the serum α-tocopherol/fat was higher and the γ-tocopherol/fat ratio lower than in mothers. Serum tocopherol levels were not associated with skin prick test reactions or atopic dermatitis in the infants. Conclusions: Maternal tocopherol status determines that of the infant. Different tocopherol forms may have different serum levels and roles in the regulation of inflammatory diseases.</description><subject>Adult</subject><subject>alpha-Tocopherol - blood</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antioxidants - metabolism</subject><subject>Asthma - blood</subject><subject>Asthma - immunology</subject><subject>Biological and medical sciences</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Dermatitis, Atopic - blood</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Female</subject><subject>gamma-Tocopherol - blood</subject><subject>Gynecology. Andrology. 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Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antioxidants - metabolism</topic><topic>Asthma - blood</topic><topic>Asthma - immunology</topic><topic>Biological and medical sciences</topic><topic>Delivery. Postpartum. Lactation</topic><topic>Dermatitis, Atopic - blood</topic><topic>Dermatitis, Atopic - immunology</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Female</topic><topic>gamma-Tocopherol - blood</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - blood</topic><topic>Hypersensitivity, Immediate - immunology</topic><topic>Infant</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>Mothers</topic><topic>Original Paper</topic><topic>Rhinitis, Allergic, Perennial - blood</topic><topic>Rhinitis, Allergic, Perennial - immunology</topic><topic>Skin Tests</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoppu, Ulla</creatorcontrib><creatorcontrib>Salo-Väänänen, Pirjo</creatorcontrib><creatorcontrib>Lampi, Anna-Maija</creatorcontrib><creatorcontrib>Isolauri, Erika</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of the neonate</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoppu, Ulla</au><au>Salo-Väänänen, Pirjo</au><au>Lampi, Anna-Maija</au><au>Isolauri, Erika</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Alpha- and Gamma-Tocopherol Levels in Atopic Mothers and Their Infants Are Correlated</atitle><jtitle>Biology of the neonate</jtitle><addtitle>Neonatology</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>88</volume><issue>1</issue><spage>24</spage><epage>26</epage><pages>24-26</pages><issn>1661-7800</issn><issn>0006-3126</issn><eissn>1661-7819</eissn><eissn>1421-9727</eissn><coden>BNEOBV</coden><abstract>Background: Vitamin E may have immunomodulatory properties beyond its antioxidant function. The objective here was to assess the α- and γ-tocopherol status and its correlation between atopic mothers and their infants. Methods: Mothers with atopic disease were recruited at the end of gestation and their infants were followed up. Serum samples from mothers and infants were collected at the infants’ age of 1 month. Atopic dermatitis was diagnosed during the 1st year of life and skin prick tests were performed at 1 year. Results: Infants’ serum γ- and α-tocopherol to fat ratios were significantly correlated with maternal serum ratios (r = 0.70, p < 0.0001 and r = 0.52, p = 0.004, respectively). In infants the serum α-tocopherol/fat was higher and the γ-tocopherol/fat ratio lower than in mothers. Serum tocopherol levels were not associated with skin prick test reactions or atopic dermatitis in the infants. Conclusions: Maternal tocopherol status determines that of the infant. Different tocopherol forms may have different serum levels and roles in the regulation of inflammatory diseases.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>15731552</pmid><doi>10.1159/000084068</doi><tpages>3</tpages></addata></record> |
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| ispartof | Biology of the neonate, 2005-01, Vol.88 (1), p.24-26 |
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| subjects | Adult alpha-Tocopherol - blood Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antioxidants - metabolism Asthma - blood Asthma - immunology Biological and medical sciences Delivery. Postpartum. Lactation Dermatitis, Atopic - blood Dermatitis, Atopic - immunology Emergency and intensive care: neonates and children. Prematurity. Sudden death Female gamma-Tocopherol - blood Gynecology. Andrology. Obstetrics Humans Hypersensitivity, Immediate - blood Hypersensitivity, Immediate - immunology Infant Intensive care medicine Medical sciences Mothers Original Paper Rhinitis, Allergic, Perennial - blood Rhinitis, Allergic, Perennial - immunology Skin Tests Statistics, Nonparametric |
| title | Serum Alpha- and Gamma-Tocopherol Levels in Atopic Mothers and Their Infants Are Correlated |
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