Interactions between Nitric Oxide and Arachidonic Acid in Lung Epithelial Cells: Possible Roles for Peroxynitrite and Superoxide

This study investigated interactions between nitric oxide synthesis and phospholipase A 2 (PLA 2 ) activation in lung epithelial cells. Nitrite formation, inducible nitric oxide synthase expression, and [ 3 H]arachidonic acid (AA) release were determined following treatment with: (1) the nitric oxid...

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Veröffentlicht in:	Pharmacology 2005-03, Vol.73 (3), p.155-161
Hauptverfasser:	Offer, Sarit, Eliraz, Abraham, Fink, Gershon, Stark, Aliza H., Madar, Zecharia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acid - metabolism Cell Line, Transformed Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Lung - drug effects Lung - enzymology Lung - metabolism Nitric Oxide - antagonists & inhibitors Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - physiology Nitric Oxide Synthase Type II Original Paper Peroxynitrous Acid - physiology Phospholipases A - antagonists & inhibitors Phospholipases A - physiology Phospholipases A2 Rats Respiratory Mucosa - drug effects Respiratory Mucosa - metabolism Signal Transduction - drug effects Signal Transduction - physiology Superoxides - pharmacology
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