Correlations between Exhaled Nitric Oxide Levels and pH-Metry Data in Asthmatics with Gastro-Oesophageal Reflux
Background: In gastro-oesophageal reflux (GER), micro-aspirations of gastric fluid may damage the epithelial surface of the airways, an important source of endogenous nitric oxide (NO). Objectives: The aim of the study was to evaluate the possible influence of GER on fractional exhaled nitric oxide...
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| Veröffentlicht in: | Respiration 2004-07, Vol.71 (4), p.329-335 |
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| creator | Silvestri, M. Mattioli, G. Defilippi, A.-C. Fregonese, B. Battistini, E. Jasonni, V. Rossi, G.A. |
| description | Background: In gastro-oesophageal reflux (GER), micro-aspirations of gastric fluid may damage the epithelial surface of the airways, an important source of endogenous nitric oxide (NO). Objectives: The aim of the study was to evaluate the possible influence of GER on fractional exhaled nitric oxide (FE NO ) release. Methods: FE NO levels were compared in two age-matched groups of allergic children: (1) 20 with mild asthma, responding to standard anti-asthma pharmacologic therapy (asthmatic children) and (2) 12 with mild ‘asthma-like symptoms’ and GER. Results: No differences in pulmonary functions parameters (FEV 1 , FVC and FEF 25–75% ) were found between the two groups of children (p > 0.1); FE NO levels were higher in asthmatic children compared with GER children (p = 0.0001). GER children underwent 24-hour oesophageal pH-metry, and possible correlations between pH-metry data, pulmonary functions and FE NO levels were evaluated. No correlations were found between pulmonary functions and pH-metry data (p > 0.05, each correlation). In contrast, correlations were observed between FE NO levels and pH-metry data, including (1) percentage of study time with pH < 4 (r = –0.80, p = 0.008), (2) number of episodes with pH < 4 (r = –0.76, p = 0.012), and (3) number of episodes >5 min with pH < 4 (r = –0.69, p = 0.02). Conclusions: Thus, FE NO levels are lower in allergic children with ‘asthma-like symptoms’ and GER as compared to asthmatic children. The correlations between FE NO levels and pH-metry data suggest that inhalation of acid gastric content may interfere with NO production in the airways. |
| doi_str_mv | 10.1159/000079635 |
| format | Article |
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Objectives: The aim of the study was to evaluate the possible influence of GER on fractional exhaled nitric oxide (FE NO ) release. Methods: FE NO levels were compared in two age-matched groups of allergic children: (1) 20 with mild asthma, responding to standard anti-asthma pharmacologic therapy (asthmatic children) and (2) 12 with mild ‘asthma-like symptoms’ and GER. Results: No differences in pulmonary functions parameters (FEV 1 , FVC and FEF 25–75% ) were found between the two groups of children (p > 0.1); FE NO levels were higher in asthmatic children compared with GER children (p = 0.0001). GER children underwent 24-hour oesophageal pH-metry, and possible correlations between pH-metry data, pulmonary functions and FE NO levels were evaluated. No correlations were found between pulmonary functions and pH-metry data (p > 0.05, each correlation). In contrast, correlations were observed between FE NO levels and pH-metry data, including (1) percentage of study time with pH < 4 (r = –0.80, p = 0.008), (2) number of episodes with pH < 4 (r = –0.76, p = 0.012), and (3) number of episodes >5 min with pH < 4 (r = –0.69, p = 0.02). Conclusions: Thus, FE NO levels are lower in allergic children with ‘asthma-like symptoms’ and GER as compared to asthmatic children. The correlations between FE NO levels and pH-metry data suggest that inhalation of acid gastric content may interfere with NO production in the airways.</description><identifier>ISSN: 0025-7931</identifier><identifier>EISSN: 1423-0356</identifier><identifier>DOI: 10.1159/000079635</identifier><identifier>PMID: 15316204</identifier><identifier>CODEN: RESPBD</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Asthma - epidemiology ; Asthma - physiopathology ; Biological and medical sciences ; Breath Tests ; Child ; Chronic obstructive pulmonary disease, asthma ; Clinical Investigations ; Comorbidity ; Esophagus ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastroesophageal Reflux - epidemiology ; Gastroesophageal Reflux - physiopathology ; Humans ; Hydrogen-Ion Concentration ; Medical sciences ; Nitric Oxide - analysis ; Nitric Oxide - biosynthesis ; Other diseases. Semiology ; Pneumology ; Respiratory Function Tests ; Respiratory System - metabolism</subject><ispartof>Respiration, 2004-07, Vol.71 (4), p.329-335</ispartof><rights>2004 S. Karger AG, Basel</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 S. Karger AG, Basel</rights><rights>Copyright (c) 2004 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-8df161f149224abf9fe9666d48c9bfc759efb6f4d76180727f0815d8e8c212cc3</citedby><cites>FETCH-LOGICAL-c385t-8df161f149224abf9fe9666d48c9bfc759efb6f4d76180727f0815d8e8c212cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16034447$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15316204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silvestri, M.</creatorcontrib><creatorcontrib>Mattioli, G.</creatorcontrib><creatorcontrib>Defilippi, A.-C.</creatorcontrib><creatorcontrib>Fregonese, B.</creatorcontrib><creatorcontrib>Battistini, E.</creatorcontrib><creatorcontrib>Jasonni, V.</creatorcontrib><creatorcontrib>Rossi, G.A.</creatorcontrib><title>Correlations between Exhaled Nitric Oxide Levels and pH-Metry Data in Asthmatics with Gastro-Oesophageal Reflux</title><title>Respiration</title><addtitle>Respiration</addtitle><description>Background: In gastro-oesophageal reflux (GER), micro-aspirations of gastric fluid may damage the epithelial surface of the airways, an important source of endogenous nitric oxide (NO). Objectives: The aim of the study was to evaluate the possible influence of GER on fractional exhaled nitric oxide (FE NO ) release. Methods: FE NO levels were compared in two age-matched groups of allergic children: (1) 20 with mild asthma, responding to standard anti-asthma pharmacologic therapy (asthmatic children) and (2) 12 with mild ‘asthma-like symptoms’ and GER. Results: No differences in pulmonary functions parameters (FEV 1 , FVC and FEF 25–75% ) were found between the two groups of children (p > 0.1); FE NO levels were higher in asthmatic children compared with GER children (p = 0.0001). GER children underwent 24-hour oesophageal pH-metry, and possible correlations between pH-metry data, pulmonary functions and FE NO levels were evaluated. No correlations were found between pulmonary functions and pH-metry data (p > 0.05, each correlation). In contrast, correlations were observed between FE NO levels and pH-metry data, including (1) percentage of study time with pH < 4 (r = –0.80, p = 0.008), (2) number of episodes with pH < 4 (r = –0.76, p = 0.012), and (3) number of episodes >5 min with pH < 4 (r = –0.69, p = 0.02). Conclusions: Thus, FE NO levels are lower in allergic children with ‘asthma-like symptoms’ and GER as compared to asthmatic children. The correlations between FE NO levels and pH-metry data suggest that inhalation of acid gastric content may interfere with NO production in the airways.</description><subject>Asthma - epidemiology</subject><subject>Asthma - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Breath Tests</subject><subject>Child</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Clinical Investigations</subject><subject>Comorbidity</subject><subject>Esophagus</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastroesophageal Reflux - epidemiology</subject><subject>Gastroesophageal Reflux - physiopathology</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Medical sciences</subject><subject>Nitric Oxide - analysis</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Other diseases. Semiology</subject><subject>Pneumology</subject><subject>Respiratory Function Tests</subject><subject>Respiratory System - metabolism</subject><issn>0025-7931</issn><issn>1423-0356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0c9rFDEUB_Agil2rB8-ChIKCh9H8nsyxbNe2sLpQ9TxkMi_dqdnJNMm02__esbttQczlHfLh-x7vIfSWks-UyuoLmV5ZKS6foRkVjBeES_UczQhhsigrTg_Qq5SuCKFSa_YSHVDJqWJEzFCYhxjBm9yFPuEG8i1AjxfbtfHQ4u9djp3Fq23XAl7CDfiETd_i4az4Bjne4ROTDe56fJzyejOF2IRvu7zGpyblGIoVpDCszSUYjy_A-XH7Gr1wxid4s6-H6NfXxc_5WbFcnZ7Pj5eF5VrmQreOKuqoqBgTpnGVg0op1Qptq8bZUlbgGuVEWyqqSclKRzSVrQZtGWXW8kP0cZc7xHA9Qsr1pksWvDc9hDHVSk0LU0RP8OgfeBXG2E-z1YxpTgQR5YQ-7ZCNIaUIrh5itzHxrqak_nuC-vEEk32_DxybDbRPcr_zCXzYA5Os8S6a3nbpySnChbhv-m7nfpt4CfERPLQ5-u_vxeLHPaiH1vE_B6Wh0w</recordid><startdate>200407</startdate><enddate>200407</enddate><creator>Silvestri, M.</creator><creator>Mattioli, G.</creator><creator>Defilippi, A.-C.</creator><creator>Fregonese, B.</creator><creator>Battistini, E.</creator><creator>Jasonni, V.</creator><creator>Rossi, G.A.</creator><general>Karger</general><general>S. 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Liver. Pancreas. Abdomen</topic><topic>Gastroesophageal Reflux - epidemiology</topic><topic>Gastroesophageal Reflux - physiopathology</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Medical sciences</topic><topic>Nitric Oxide - analysis</topic><topic>Nitric Oxide - biosynthesis</topic><topic>Other diseases. Semiology</topic><topic>Pneumology</topic><topic>Respiratory Function Tests</topic><topic>Respiratory System - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silvestri, M.</creatorcontrib><creatorcontrib>Mattioli, G.</creatorcontrib><creatorcontrib>Defilippi, A.-C.</creatorcontrib><creatorcontrib>Fregonese, B.</creatorcontrib><creatorcontrib>Battistini, E.</creatorcontrib><creatorcontrib>Jasonni, V.</creatorcontrib><creatorcontrib>Rossi, G.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Respiration</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silvestri, M.</au><au>Mattioli, G.</au><au>Defilippi, A.-C.</au><au>Fregonese, B.</au><au>Battistini, E.</au><au>Jasonni, V.</au><au>Rossi, G.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlations between Exhaled Nitric Oxide Levels and pH-Metry Data in Asthmatics with Gastro-Oesophageal Reflux</atitle><jtitle>Respiration</jtitle><addtitle>Respiration</addtitle><date>2004-07</date><risdate>2004</risdate><volume>71</volume><issue>4</issue><spage>329</spage><epage>335</epage><pages>329-335</pages><issn>0025-7931</issn><eissn>1423-0356</eissn><coden>RESPBD</coden><abstract>Background: In gastro-oesophageal reflux (GER), micro-aspirations of gastric fluid may damage the epithelial surface of the airways, an important source of endogenous nitric oxide (NO). Objectives: The aim of the study was to evaluate the possible influence of GER on fractional exhaled nitric oxide (FE NO ) release. Methods: FE NO levels were compared in two age-matched groups of allergic children: (1) 20 with mild asthma, responding to standard anti-asthma pharmacologic therapy (asthmatic children) and (2) 12 with mild ‘asthma-like symptoms’ and GER. Results: No differences in pulmonary functions parameters (FEV 1 , FVC and FEF 25–75% ) were found between the two groups of children (p > 0.1); FE NO levels were higher in asthmatic children compared with GER children (p = 0.0001). GER children underwent 24-hour oesophageal pH-metry, and possible correlations between pH-metry data, pulmonary functions and FE NO levels were evaluated. No correlations were found between pulmonary functions and pH-metry data (p > 0.05, each correlation). In contrast, correlations were observed between FE NO levels and pH-metry data, including (1) percentage of study time with pH < 4 (r = –0.80, p = 0.008), (2) number of episodes with pH < 4 (r = –0.76, p = 0.012), and (3) number of episodes >5 min with pH < 4 (r = –0.69, p = 0.02). Conclusions: Thus, FE NO levels are lower in allergic children with ‘asthma-like symptoms’ and GER as compared to asthmatic children. The correlations between FE NO levels and pH-metry data suggest that inhalation of acid gastric content may interfere with NO production in the airways.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>15316204</pmid><doi>10.1159/000079635</doi><tpages>7</tpages></addata></record> |
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| subjects | Asthma - epidemiology Asthma - physiopathology Biological and medical sciences Breath Tests Child Chronic obstructive pulmonary disease, asthma Clinical Investigations Comorbidity Esophagus Gastroenterology. Liver. Pancreas. Abdomen Gastroesophageal Reflux - epidemiology Gastroesophageal Reflux - physiopathology Humans Hydrogen-Ion Concentration Medical sciences Nitric Oxide - analysis Nitric Oxide - biosynthesis Other diseases. Semiology Pneumology Respiratory Function Tests Respiratory System - metabolism |
| title | Correlations between Exhaled Nitric Oxide Levels and pH-Metry Data in Asthmatics with Gastro-Oesophageal Reflux |
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