Insulin Tolerance Test Causes Hypokalaemia and Can Provoke Cardiac Arrhythmias
We report the observation and analysis of a new adverse event during the insulin tolerance test (ITT) and propose additional safety procedures. An 8-year-old girl with growth hormone insufficiency had a cardiac arrest due to ventricular flutter when she was tested for growth hormone deficiency by th...
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| Veröffentlicht in: | Hormone research 2004-01, Vol.62 (2), p.84-87 |
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| creator | Binder, Gerhard Bosk, Axel Gass, Matthias Ranke, Michael B. Heidemann, Peter H. |
| description | We report the observation and analysis of a new adverse event during the insulin tolerance test (ITT) and propose additional safety procedures. An 8-year-old girl with growth hormone insufficiency had a cardiac arrest due to ventricular flutter when she was tested for growth hormone deficiency by the ITT. Severe hypokalaemia (K + 2.6 mmol/l) was observed after resuscitation. Ergometry ECG revealed catecholaminergic polymorphic ventricular tachycardia, a hereditary arrhythmogenic disease. Consecutive measurements of serum potassium during ITT in 29 short children (21 boys) with growth failure revealed a mean decrease of serum potassium by 1.1 ± 0.4 mmol/l with the nadir at 30 min after the insulin bolus. Hypokalaemia (serum potassium |
| doi_str_mv | 10.1159/000079539 |
| format | Article |
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An 8-year-old girl with growth hormone insufficiency had a cardiac arrest due to ventricular flutter when she was tested for growth hormone deficiency by the ITT. Severe hypokalaemia (K + 2.6 mmol/l) was observed after resuscitation. Ergometry ECG revealed catecholaminergic polymorphic ventricular tachycardia, a hereditary arrhythmogenic disease. Consecutive measurements of serum potassium during ITT in 29 short children (21 boys) with growth failure revealed a mean decrease of serum potassium by 1.1 ± 0.4 mmol/l with the nadir at 30 min after the insulin bolus. Hypokalaemia (serum potassium <3.5 mmol/l) occurred in all but one child; severe hypokalaemia (serum potassium <2.9 mmol/l) was measured in every third child. This observation indicates that acute hypokalaemia which is induced by insulin and catecholamine excess occurs frequently in ITT. The case shows that the combination of acute hypokalaemia and the adrenergic counterregulation in ITT is a strong trigger of cardiac arrhythmias, which can become life-threatening if the child has an arrhythmogenic disease. Therefore, we recommend ECG monitoring during ITT to enhance the detection of cardiac arrhythmias. In addition, in the case of a comatose child during ITT the determination of the glucose and potassium level as well as adequate treatment are necessary.</description><identifier>ISSN: 1663-2818</identifier><identifier>ISSN: 0301-0163</identifier><identifier>EISSN: 1663-2826</identifier><identifier>DOI: 10.1159/000079539</identifier><identifier>PMID: 15249739</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adolescent ; Arrhythmias, Cardiac - chemically induced ; Arrhythmias, Cardiac - diagnosis ; Blood Glucose ; Case Report ; Child ; Child, Preschool ; Diagnostic Tests, Routine - adverse effects ; Dwarfism, Pituitary - diagnosis ; Female ; Humans ; Hypokalemia - chemically induced ; Insulin - adverse effects ; Male</subject><ispartof>Hormone research, 2004-01, Vol.62 (2), p.84-87</ispartof><rights>2004 S. Karger AG, Basel</rights><rights>Copyright (c) 2004 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-f91e349395b30845dd9426095cb0e213176860d507cffadc11f1494488bc1c803</citedby><cites>FETCH-LOGICAL-c422t-f91e349395b30845dd9426095cb0e213176860d507cffadc11f1494488bc1c803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15249739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Binder, Gerhard</creatorcontrib><creatorcontrib>Bosk, Axel</creatorcontrib><creatorcontrib>Gass, Matthias</creatorcontrib><creatorcontrib>Ranke, Michael B.</creatorcontrib><creatorcontrib>Heidemann, Peter H.</creatorcontrib><title>Insulin Tolerance Test Causes Hypokalaemia and Can Provoke Cardiac Arrhythmias</title><title>Hormone research</title><addtitle>Horm Res Paediatr</addtitle><description>We report the observation and analysis of a new adverse event during the insulin tolerance test (ITT) and propose additional safety procedures. An 8-year-old girl with growth hormone insufficiency had a cardiac arrest due to ventricular flutter when she was tested for growth hormone deficiency by the ITT. Severe hypokalaemia (K + 2.6 mmol/l) was observed after resuscitation. Ergometry ECG revealed catecholaminergic polymorphic ventricular tachycardia, a hereditary arrhythmogenic disease. Consecutive measurements of serum potassium during ITT in 29 short children (21 boys) with growth failure revealed a mean decrease of serum potassium by 1.1 ± 0.4 mmol/l with the nadir at 30 min after the insulin bolus. Hypokalaemia (serum potassium <3.5 mmol/l) occurred in all but one child; severe hypokalaemia (serum potassium <2.9 mmol/l) was measured in every third child. This observation indicates that acute hypokalaemia which is induced by insulin and catecholamine excess occurs frequently in ITT. The case shows that the combination of acute hypokalaemia and the adrenergic counterregulation in ITT is a strong trigger of cardiac arrhythmias, which can become life-threatening if the child has an arrhythmogenic disease. Therefore, we recommend ECG monitoring during ITT to enhance the detection of cardiac arrhythmias. In addition, in the case of a comatose child during ITT the determination of the glucose and potassium level as well as adequate treatment are necessary.</description><subject>Adolescent</subject><subject>Arrhythmias, Cardiac - chemically induced</subject><subject>Arrhythmias, Cardiac - diagnosis</subject><subject>Blood Glucose</subject><subject>Case Report</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diagnostic Tests, Routine - adverse effects</subject><subject>Dwarfism, Pituitary - diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Hypokalemia - chemically induced</subject><subject>Insulin - adverse effects</subject><subject>Male</subject><issn>1663-2818</issn><issn>0301-0163</issn><issn>1663-2826</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpt0EFPwjAUB_DGaIQgB88mZtGTh2lf223tkSwoJESNwfPStZ0MxjZbZsK3twjixV760v76XvNH6BLwPUAkHrBfiYioOEF9iGMaEk7i02MNvIeGzi13jPJEQHKOehARJhIq-uh5WruuKutg3lTGylqZYG7cJkhl54wLJtu2WclKmnUpA1lrf14Hr7b5albG11aXUgUjaxfbzcITd4HOClk5MzzsA_T-OJ6nk3D28jRNR7NQMUI2YSHAUCaoiHKKOYu0FozEWEQqx4YAhSTmMdYRTlRRSK0ACmCCMc5zBYpjOkC3-76tbT47_-Fs2XS29iMzwLEgzDcRXt3tlbKNc9YUWWvLtbRbj7JdeNkxPG-vDx27fG30nzxE5cHVHqyk_TD2CH6f3_x7O3kb_4Cs1QX9Bm8Ie54</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Binder, Gerhard</creator><creator>Bosk, Axel</creator><creator>Gass, Matthias</creator><creator>Ranke, Michael B.</creator><creator>Heidemann, Peter H.</creator><general>S. 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An 8-year-old girl with growth hormone insufficiency had a cardiac arrest due to ventricular flutter when she was tested for growth hormone deficiency by the ITT. Severe hypokalaemia (K + 2.6 mmol/l) was observed after resuscitation. Ergometry ECG revealed catecholaminergic polymorphic ventricular tachycardia, a hereditary arrhythmogenic disease. Consecutive measurements of serum potassium during ITT in 29 short children (21 boys) with growth failure revealed a mean decrease of serum potassium by 1.1 ± 0.4 mmol/l with the nadir at 30 min after the insulin bolus. Hypokalaemia (serum potassium <3.5 mmol/l) occurred in all but one child; severe hypokalaemia (serum potassium <2.9 mmol/l) was measured in every third child. This observation indicates that acute hypokalaemia which is induced by insulin and catecholamine excess occurs frequently in ITT. The case shows that the combination of acute hypokalaemia and the adrenergic counterregulation in ITT is a strong trigger of cardiac arrhythmias, which can become life-threatening if the child has an arrhythmogenic disease. Therefore, we recommend ECG monitoring during ITT to enhance the detection of cardiac arrhythmias. In addition, in the case of a comatose child during ITT the determination of the glucose and potassium level as well as adequate treatment are necessary.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>15249739</pmid><doi>10.1159/000079539</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - diagnosis Blood Glucose Case Report Child Child, Preschool Diagnostic Tests, Routine - adverse effects Dwarfism, Pituitary - diagnosis Female Humans Hypokalemia - chemically induced Insulin - adverse effects Male |
| title | Insulin Tolerance Test Causes Hypokalaemia and Can Provoke Cardiac Arrhythmias |
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