Topical Activity of Ascorbic Acid: From in vitro Optimization to in vivo Efficacy

We present here a new cosmetic formula system containing 3% ascorbic acid based on an optimized oil-in-water (O/W) emulsion. This formulation demonstrated a good long-term stability of the active ingredient and also of the emulsion itself. It could be deduced from in vitro release studies that this...

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Veröffentlicht in:	Skin pharmacology and physiology 2004-07, Vol.17 (4), p.200-206
Hauptverfasser:	Raschke, T., Koop, U., Düsing, H.-J., Filbry, A., Sauermann, K., Jaspers, S., Wenck, H., Wittern, K.-P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Antioxidants - administration & dosage Antioxidants - pharmacology Ascorbic Acid - administration & dosage Ascorbic Acid - chemistry Ascorbic Acid - pharmacology Controlled Clinical Trials as Topic Cosmetics - chemistry Cosmetics - pharmacology Diffusion Drug Compounding - methods Drug Stability Emulsions Excipients - administration & dosage Female Humans Microscopy, Confocal - instrumentation Middle Aged Original Paper Oxidative Stress - drug effects Reproducibility of Results Skin Aging - drug effects Skin Aging - pathology Treatment Outcome Ultraviolet Rays - adverse effects
Online-Zugang:	Volltext
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