Attentional Modulation of Prepulse Inhibition: A New Startle Paradigm

There is increasing evidence for an influence of directed attention on prepulse inhibition (PPI) of the acoustic startle reflex. However, the existing paradigms for the assessment of this effect have methodological problems and pitfalls. In particular, most previous studies used a paradigm which dir...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neuropsychobiology 2004-01, Vol.49 (2), p.88-93
Hauptverfasser: Heekeren, Karsten, Meincke, Ulrich, Geyer, Mark A., Gouzoulis-Mayfrank, Euphrosyne
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 93
container_issue 2
container_start_page 88
container_title Neuropsychobiology
container_volume 49
creator Heekeren, Karsten
Meincke, Ulrich
Geyer, Mark A.
Gouzoulis-Mayfrank, Euphrosyne
description There is increasing evidence for an influence of directed attention on prepulse inhibition (PPI) of the acoustic startle reflex. However, the existing paradigms for the assessment of this effect have methodological problems and pitfalls. In particular, most previous studies used a paradigm which directed the attention of subjects to the prepulse only. In the present study, we used a modified paradigm which directed the attention of the subjects both to the prepulse and the pulse. Twenty healthy male subjects were instructed trial by trial either to relax or to attend to the startle stimulus and decide whether it was a ‘simple’ (prepulse alone or pulse alone) or a ‘composite’ trial (pulse plus a prepulse or postpulse). Directed attention enhanced PPI at the lead interval of 240 ms, but not at the lead interval of 100 ms. This finding is in line with the idea that attention contributes to PPI when there is enough time for the attentional mechanisms to exert an influence. This new paradigm offers a valuable tool for the study of attentional modulation of sensorimotor gating in humans.
doi_str_mv 10.1159/000076416
format Article
fullrecord <record><control><sourceid>proquest_karge</sourceid><recordid>TN_cdi_karger_primary_76416</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71670843</sourcerecordid><originalsourceid>FETCH-LOGICAL-c385t-3076540851ef413455eb4603c02235d904f0de3d89727d3b8df28214e780ac273</originalsourceid><addsrcrecordid>eNpt0EtLwzAcAPAgipvTg2dBykDBQzXPpvU2xtTBnIMpeCtpk87OvkxaxG9v6uoGYnIISX78XwCcIniNEAtuoF3co8jbA31EMXEhxnQf9CGB2MU-fu2BI2PWECIa8OAQ9OzpI0JhH0xGda2KOi0LkTmPpWwy0V6cMnEWWlVNZpQzLd7SKG2fb52RM1efzrIWus6UsxBayHSVH4ODRFh60p0D8HI3eR4_uLOn--l4NHNj4rPaJbZKRqHPkEqozc-YiqgHSWzrJUwGkCZQKiL9gGMuSeTLxFaPqOI-FDHmZAAuN3ErXX40ytRhnppYZZkoVNmYkCOPQ58SC4d_4LpstO3RhJgQSrndFl1tUKxLY7RKwkqnudBfIYJhO9hwO1hrz7uATZQruZPdJC246IAwscgSLYo4NTvHGLK9tIHONu5d6JXSW_CbZvjv73yx_AFhJRPyDek7kPg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>233447474</pqid></control><display><type>article</type><title>Attentional Modulation of Prepulse Inhibition: A New Startle Paradigm</title><source>Karger Journals</source><source>MEDLINE</source><creator>Heekeren, Karsten ; Meincke, Ulrich ; Geyer, Mark A. ; Gouzoulis-Mayfrank, Euphrosyne</creator><creatorcontrib>Heekeren, Karsten ; Meincke, Ulrich ; Geyer, Mark A. ; Gouzoulis-Mayfrank, Euphrosyne</creatorcontrib><description>There is increasing evidence for an influence of directed attention on prepulse inhibition (PPI) of the acoustic startle reflex. However, the existing paradigms for the assessment of this effect have methodological problems and pitfalls. In particular, most previous studies used a paradigm which directed the attention of subjects to the prepulse only. In the present study, we used a modified paradigm which directed the attention of the subjects both to the prepulse and the pulse. Twenty healthy male subjects were instructed trial by trial either to relax or to attend to the startle stimulus and decide whether it was a ‘simple’ (prepulse alone or pulse alone) or a ‘composite’ trial (pulse plus a prepulse or postpulse). Directed attention enhanced PPI at the lead interval of 240 ms, but not at the lead interval of 100 ms. This finding is in line with the idea that attention contributes to PPI when there is enough time for the attentional mechanisms to exert an influence. This new paradigm offers a valuable tool for the study of attentional modulation of sensorimotor gating in humans.</description><identifier>ISSN: 0302-282X</identifier><identifier>EISSN: 1423-0224</identifier><identifier>DOI: 10.1159/000076416</identifier><identifier>PMID: 14981340</identifier><identifier>CODEN: NPBYAL</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Acoustic Stimulation - methods ; Activity levels. Psychomotricity ; Adult ; Attention - physiology ; Attention - radiation effects ; Biological and medical sciences ; Biological Psychology/Pharmacopsychology. Editor: P. Netter (Giessen). Original Paper ; Fundamental and applied biological sciences. Psychology ; Humans ; Inhibition (Psychology) ; Male ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Reaction Time ; Reflex, Acoustic - physiology ; Reflex, Acoustic - radiation effects ; Reflex, Startle - physiology ; Reflex, Startle - radiation effects ; Relaxation - physiology ; Time Factors ; Vigilance. Attention. Sleep</subject><ispartof>Neuropsychobiology, 2004-01, Vol.49 (2), p.88-93</ispartof><rights>2004 S. Karger AG, Basel</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 S. Karger AG, Basel</rights><rights>Copyright (c) 2004 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-3076540851ef413455eb4603c02235d904f0de3d89727d3b8df28214e780ac273</citedby><cites>FETCH-LOGICAL-c385t-3076540851ef413455eb4603c02235d904f0de3d89727d3b8df28214e780ac273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=15512826$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14981340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heekeren, Karsten</creatorcontrib><creatorcontrib>Meincke, Ulrich</creatorcontrib><creatorcontrib>Geyer, Mark A.</creatorcontrib><creatorcontrib>Gouzoulis-Mayfrank, Euphrosyne</creatorcontrib><title>Attentional Modulation of Prepulse Inhibition: A New Startle Paradigm</title><title>Neuropsychobiology</title><addtitle>Neuropsychobiology</addtitle><description>There is increasing evidence for an influence of directed attention on prepulse inhibition (PPI) of the acoustic startle reflex. However, the existing paradigms for the assessment of this effect have methodological problems and pitfalls. In particular, most previous studies used a paradigm which directed the attention of subjects to the prepulse only. In the present study, we used a modified paradigm which directed the attention of the subjects both to the prepulse and the pulse. Twenty healthy male subjects were instructed trial by trial either to relax or to attend to the startle stimulus and decide whether it was a ‘simple’ (prepulse alone or pulse alone) or a ‘composite’ trial (pulse plus a prepulse or postpulse). Directed attention enhanced PPI at the lead interval of 240 ms, but not at the lead interval of 100 ms. This finding is in line with the idea that attention contributes to PPI when there is enough time for the attentional mechanisms to exert an influence. This new paradigm offers a valuable tool for the study of attentional modulation of sensorimotor gating in humans.</description><subject>Acoustic Stimulation - methods</subject><subject>Activity levels. Psychomotricity</subject><subject>Adult</subject><subject>Attention - physiology</subject><subject>Attention - radiation effects</subject><subject>Biological and medical sciences</subject><subject>Biological Psychology/Pharmacopsychology. Editor: P. Netter (Giessen). Original Paper</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Inhibition (Psychology)</subject><subject>Male</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Reaction Time</subject><subject>Reflex, Acoustic - physiology</subject><subject>Reflex, Acoustic - radiation effects</subject><subject>Reflex, Startle - physiology</subject><subject>Reflex, Startle - radiation effects</subject><subject>Relaxation - physiology</subject><subject>Time Factors</subject><subject>Vigilance. Attention. Sleep</subject><issn>0302-282X</issn><issn>1423-0224</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpt0EtLwzAcAPAgipvTg2dBykDBQzXPpvU2xtTBnIMpeCtpk87OvkxaxG9v6uoGYnIISX78XwCcIniNEAtuoF3co8jbA31EMXEhxnQf9CGB2MU-fu2BI2PWECIa8OAQ9OzpI0JhH0xGda2KOi0LkTmPpWwy0V6cMnEWWlVNZpQzLd7SKG2fb52RM1efzrIWus6UsxBayHSVH4ODRFh60p0D8HI3eR4_uLOn--l4NHNj4rPaJbZKRqHPkEqozc-YiqgHSWzrJUwGkCZQKiL9gGMuSeTLxFaPqOI-FDHmZAAuN3ErXX40ytRhnppYZZkoVNmYkCOPQ58SC4d_4LpstO3RhJgQSrndFl1tUKxLY7RKwkqnudBfIYJhO9hwO1hrz7uATZQruZPdJC246IAwscgSLYo4NTvHGLK9tIHONu5d6JXSW_CbZvjv73yx_AFhJRPyDek7kPg</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Heekeren, Karsten</creator><creator>Meincke, Ulrich</creator><creator>Geyer, Mark A.</creator><creator>Gouzoulis-Mayfrank, Euphrosyne</creator><general>Karger</general><general>S. Karger AG</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20040101</creationdate><title>Attentional Modulation of Prepulse Inhibition: A New Startle Paradigm</title><author>Heekeren, Karsten ; Meincke, Ulrich ; Geyer, Mark A. ; Gouzoulis-Mayfrank, Euphrosyne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-3076540851ef413455eb4603c02235d904f0de3d89727d3b8df28214e780ac273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acoustic Stimulation - methods</topic><topic>Activity levels. Psychomotricity</topic><topic>Adult</topic><topic>Attention - physiology</topic><topic>Attention - radiation effects</topic><topic>Biological and medical sciences</topic><topic>Biological Psychology/Pharmacopsychology. Editor: P. Netter (Giessen). Original Paper</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Inhibition (Psychology)</topic><topic>Male</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Reaction Time</topic><topic>Reflex, Acoustic - physiology</topic><topic>Reflex, Acoustic - radiation effects</topic><topic>Reflex, Startle - physiology</topic><topic>Reflex, Startle - radiation effects</topic><topic>Relaxation - physiology</topic><topic>Time Factors</topic><topic>Vigilance. Attention. Sleep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heekeren, Karsten</creatorcontrib><creatorcontrib>Meincke, Ulrich</creatorcontrib><creatorcontrib>Geyer, Mark A.</creatorcontrib><creatorcontrib>Gouzoulis-Mayfrank, Euphrosyne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropsychobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heekeren, Karsten</au><au>Meincke, Ulrich</au><au>Geyer, Mark A.</au><au>Gouzoulis-Mayfrank, Euphrosyne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Attentional Modulation of Prepulse Inhibition: A New Startle Paradigm</atitle><jtitle>Neuropsychobiology</jtitle><addtitle>Neuropsychobiology</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>49</volume><issue>2</issue><spage>88</spage><epage>93</epage><pages>88-93</pages><issn>0302-282X</issn><eissn>1423-0224</eissn><coden>NPBYAL</coden><abstract>There is increasing evidence for an influence of directed attention on prepulse inhibition (PPI) of the acoustic startle reflex. However, the existing paradigms for the assessment of this effect have methodological problems and pitfalls. In particular, most previous studies used a paradigm which directed the attention of subjects to the prepulse only. In the present study, we used a modified paradigm which directed the attention of the subjects both to the prepulse and the pulse. Twenty healthy male subjects were instructed trial by trial either to relax or to attend to the startle stimulus and decide whether it was a ‘simple’ (prepulse alone or pulse alone) or a ‘composite’ trial (pulse plus a prepulse or postpulse). Directed attention enhanced PPI at the lead interval of 240 ms, but not at the lead interval of 100 ms. This finding is in line with the idea that attention contributes to PPI when there is enough time for the attentional mechanisms to exert an influence. This new paradigm offers a valuable tool for the study of attentional modulation of sensorimotor gating in humans.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>14981340</pmid><doi>10.1159/000076416</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0302-282X
ispartof Neuropsychobiology, 2004-01, Vol.49 (2), p.88-93
issn 0302-282X
1423-0224
language eng
recordid cdi_karger_primary_76416
source Karger Journals; MEDLINE
subjects Acoustic Stimulation - methods
Activity levels. Psychomotricity
Adult
Attention - physiology
Attention - radiation effects
Biological and medical sciences
Biological Psychology/Pharmacopsychology. Editor: P. Netter (Giessen). Original Paper
Fundamental and applied biological sciences. Psychology
Humans
Inhibition (Psychology)
Male
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Reaction Time
Reflex, Acoustic - physiology
Reflex, Acoustic - radiation effects
Reflex, Startle - physiology
Reflex, Startle - radiation effects
Relaxation - physiology
Time Factors
Vigilance. Attention. Sleep
title Attentional Modulation of Prepulse Inhibition: A New Startle Paradigm
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T22%3A03%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_karge&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Attentional%20Modulation%20of%20Prepulse%20Inhibition:%20A%20New%20Startle%20Paradigm&rft.jtitle=Neuropsychobiology&rft.au=Heekeren,%20Karsten&rft.date=2004-01-01&rft.volume=49&rft.issue=2&rft.spage=88&rft.epage=93&rft.pages=88-93&rft.issn=0302-282X&rft.eissn=1423-0224&rft.coden=NPBYAL&rft_id=info:doi/10.1159/000076416&rft_dat=%3Cproquest_karge%3E71670843%3C/proquest_karge%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=233447474&rft_id=info:pmid/14981340&rfr_iscdi=true