Salsolinol Causing Parkinsonism Activates Endoplasmic Reticulum-Stress Signaling Pathways in Human Dopaminergic SK-N-SH Cells

The endoplasmic reticulum (ER) is a small intracellular organelle to which one-third of cellular proteins are translocated after translation and post-translational modification, folding and the formation of a three- or four-dimensional structure. ER also has a role in the transportation of proteins...

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Veröffentlicht in:	Neuro-Signals 2003-01, Vol.12 (6), p.315-324
Hauptverfasser:	Kheradpezhouh, Mohsen, Shavali, Shaik, Ebadi, Manuchair
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western - methods Carrier Proteins - metabolism CCAAT-Enhancer-Binding Proteins - metabolism Cell Line, Tumor Cell Survival - drug effects DNA-Binding Proteins - metabolism Dopamine - metabolism Dose-Response Relationship, Drug eIF-2 Kinase - metabolism Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Fluorescent Antibody Technique - methods Heat-Shock Proteins Humans Isoquinolines - toxicity Molecular Chaperones Neuroblastoma Original Paper Parkinsonian Disorders - chemically induced Parkinsonian Disorders - metabolism Phosphorylation - drug effects Stress, Physiological - chemically induced Stress, Physiological - metabolism Tetrahydroisoquinolines - toxicity Time Factors Transcription Factor CHOP Transcription Factors - metabolism
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