Predictive Factors of Radiation Necrosis after Radiosurgery for Cerebral Metastases
The aim of this study was to determine if the risk of radiation necrosis after radiosurgery is related to the presence of normal tissue included in the prescription volume. Between 1994 and 2001, 377 patients representing 760 lesions were treated by radiosurgery in our center with a 10-MV LINAC. The...
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| Veröffentlicht in: | Stereotactic and functional neurosurgery 2003-01, Vol.81 (1-4), p.115-119 |
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| container_title | Stereotactic and functional neurosurgery |
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| creator | Valéry, Charles A. Cornu, Philippe Noël, Georges Duyme, Michel Boisserie, Gilbert Sakka, Laurent J. Mazeron, Jean-Jacques van Effenterre, Rémy |
| description | The aim of this study was to determine if the risk of radiation necrosis after radiosurgery is related to the presence of normal tissue included in the prescription volume. Between 1994 and 2001, 377 patients representing 760 lesions were treated by radiosurgery in our center with a 10-MV LINAC. The median age of the patients was 57 years (range 30–86 years), median tumor volume was 4.9 cm 3 , median peripheral dose (70%) was 15.6 Gy and median dose at the isocenter was 21.6 Gy. Karnofsky index, disease control and number of lesions were the only parameters significantly influencing survival (median 8.6 months), while disease-free survival was correlated with the number of isocenters. Seven percent of the patients presented severe complications, including nine episodes of radiation necrosis. The only parameter influencing the risk of radiation necrosis was the conformity index (p = 0.001). These findings emphasize the importance of reducing falsely irradiated normal tissue during radiosurgery to prevent radiation necrosis. |
| doi_str_mv | 10.1159/000075114 |
| format | Article |
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Between 1994 and 2001, 377 patients representing 760 lesions were treated by radiosurgery in our center with a 10-MV LINAC. The median age of the patients was 57 years (range 30–86 years), median tumor volume was 4.9 cm 3 , median peripheral dose (70%) was 15.6 Gy and median dose at the isocenter was 21.6 Gy. Karnofsky index, disease control and number of lesions were the only parameters significantly influencing survival (median 8.6 months), while disease-free survival was correlated with the number of isocenters. Seven percent of the patients presented severe complications, including nine episodes of radiation necrosis. The only parameter influencing the risk of radiation necrosis was the conformity index (p = 0.001). These findings emphasize the importance of reducing falsely irradiated normal tissue during radiosurgery to prevent radiation necrosis.</description><identifier>ISSN: 1011-6125</identifier><identifier>ISBN: 3805576609</identifier><identifier>ISBN: 9783805576604</identifier><identifier>EISSN: 1423-0372</identifier><identifier>EISBN: 3318010367</identifier><identifier>EISBN: 9783318010367</identifier><identifier>DOI: 10.1159/000075114</identifier><identifier>PMID: 14742974</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Alia ; Brain - pathology ; Brain Neoplasms - mortality ; Brain Neoplasms - pathology ; Brain Neoplasms - surgery ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Necrosis ; Postoperative Complications - mortality ; Postoperative Complications - pathology ; Predictive Value of Tests ; Radiation Dosage ; Radiosurgery - adverse effects ; Survival Analysis</subject><ispartof>Stereotactic and functional neurosurgery, 2003-01, Vol.81 (1-4), p.115-119</ispartof><rights>2003 S. Karger AG, Basel</rights><rights>Copyright 2003 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-a66e8a7d6fcb491a6d8a4ab48098cbf15c358cec8e5c412acf3e9094b246af583</citedby><cites>FETCH-LOGICAL-c328t-a66e8a7d6fcb491a6d8a4ab48098cbf15c358cec8e5c412acf3e9094b246af583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,2430,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14742974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Valéry, Charles A.</creatorcontrib><creatorcontrib>Cornu, Philippe</creatorcontrib><creatorcontrib>Noël, Georges</creatorcontrib><creatorcontrib>Duyme, Michel</creatorcontrib><creatorcontrib>Boisserie, Gilbert</creatorcontrib><creatorcontrib>Sakka, Laurent J.</creatorcontrib><creatorcontrib>Mazeron, Jean-Jacques</creatorcontrib><creatorcontrib>van Effenterre, Rémy</creatorcontrib><title>Predictive Factors of Radiation Necrosis after Radiosurgery for Cerebral Metastases</title><title>Stereotactic and functional neurosurgery</title><addtitle>Stereotact Funct Neurosurg</addtitle><description>The aim of this study was to determine if the risk of radiation necrosis after radiosurgery is related to the presence of normal tissue included in the prescription volume. Between 1994 and 2001, 377 patients representing 760 lesions were treated by radiosurgery in our center with a 10-MV LINAC. The median age of the patients was 57 years (range 30–86 years), median tumor volume was 4.9 cm 3 , median peripheral dose (70%) was 15.6 Gy and median dose at the isocenter was 21.6 Gy. Karnofsky index, disease control and number of lesions were the only parameters significantly influencing survival (median 8.6 months), while disease-free survival was correlated with the number of isocenters. Seven percent of the patients presented severe complications, including nine episodes of radiation necrosis. The only parameter influencing the risk of radiation necrosis was the conformity index (p = 0.001). These findings emphasize the importance of reducing falsely irradiated normal tissue during radiosurgery to prevent radiation necrosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alia</subject><subject>Brain - pathology</subject><subject>Brain Neoplasms - mortality</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Necrosis</subject><subject>Postoperative Complications - mortality</subject><subject>Postoperative Complications - pathology</subject><subject>Predictive Value of Tests</subject><subject>Radiation Dosage</subject><subject>Radiosurgery - adverse effects</subject><subject>Survival Analysis</subject><issn>1011-6125</issn><issn>1423-0372</issn><isbn>3805576609</isbn><isbn>9783805576604</isbn><isbn>3318010367</isbn><isbn>9783318010367</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkElPwzAQhc0musCBMxKyuHEIeOIlzhFVFJBKQRTOkeOMUaAllZ0i9d_jLioXRiPN4X2zPULOgF0DyPyGxcgkgNgjPc5BM2BcZfukCyLlCeNZehAFzaTMlGL5YRQYQKIglR3SC-Ez9nOR6WPSAZGJNM9El0xePFa1besfpENj28YH2jj6aqratHXzTcdofRPqQI1r0a-FJiz8B_oldY2nA_RYejOlT9iaEBPDCTlyZhrwdFv75H149zZ4SEbP94-D21FiearbxCiF2mSVcrYUORhVaSNMKTTLtS0dSMultmg1SisgNdZxzFkuylQo46TmfXK1mbu6MHh0xdzXM-OXBbBiZVmxsyyyFxt2vihnWP2RWycicLkBvszquR0wGY7XE4p55SJ0_i-02fEL9Qx3XA</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>Valéry, Charles A.</creator><creator>Cornu, Philippe</creator><creator>Noël, Georges</creator><creator>Duyme, Michel</creator><creator>Boisserie, Gilbert</creator><creator>Sakka, Laurent J.</creator><creator>Mazeron, Jean-Jacques</creator><creator>van Effenterre, Rémy</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20030101</creationdate><title>Predictive Factors of Radiation Necrosis after Radiosurgery for Cerebral Metastases</title><author>Valéry, Charles A. ; Cornu, Philippe ; Noël, Georges ; Duyme, Michel ; Boisserie, Gilbert ; Sakka, Laurent J. ; Mazeron, Jean-Jacques ; van Effenterre, Rémy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-a66e8a7d6fcb491a6d8a4ab48098cbf15c358cec8e5c412acf3e9094b246af583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alia</topic><topic>Brain - pathology</topic><topic>Brain Neoplasms - mortality</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain Neoplasms - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Necrosis</topic><topic>Postoperative Complications - mortality</topic><topic>Postoperative Complications - pathology</topic><topic>Predictive Value of Tests</topic><topic>Radiation Dosage</topic><topic>Radiosurgery - adverse effects</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Valéry, Charles A.</creatorcontrib><creatorcontrib>Cornu, Philippe</creatorcontrib><creatorcontrib>Noël, Georges</creatorcontrib><creatorcontrib>Duyme, Michel</creatorcontrib><creatorcontrib>Boisserie, Gilbert</creatorcontrib><creatorcontrib>Sakka, Laurent J.</creatorcontrib><creatorcontrib>Mazeron, Jean-Jacques</creatorcontrib><creatorcontrib>van Effenterre, Rémy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Stereotactic and functional neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Valéry, Charles A.</au><au>Cornu, Philippe</au><au>Noël, Georges</au><au>Duyme, Michel</au><au>Boisserie, Gilbert</au><au>Sakka, Laurent J.</au><au>Mazeron, Jean-Jacques</au><au>van Effenterre, Rémy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive Factors of Radiation Necrosis after Radiosurgery for Cerebral Metastases</atitle><jtitle>Stereotactic and functional neurosurgery</jtitle><addtitle>Stereotact Funct Neurosurg</addtitle><date>2003-01-01</date><risdate>2003</risdate><volume>81</volume><issue>1-4</issue><spage>115</spage><epage>119</epage><pages>115-119</pages><issn>1011-6125</issn><eissn>1423-0372</eissn><isbn>3805576609</isbn><isbn>9783805576604</isbn><eisbn>3318010367</eisbn><eisbn>9783318010367</eisbn><abstract>The aim of this study was to determine if the risk of radiation necrosis after radiosurgery is related to the presence of normal tissue included in the prescription volume. Between 1994 and 2001, 377 patients representing 760 lesions were treated by radiosurgery in our center with a 10-MV LINAC. The median age of the patients was 57 years (range 30–86 years), median tumor volume was 4.9 cm 3 , median peripheral dose (70%) was 15.6 Gy and median dose at the isocenter was 21.6 Gy. Karnofsky index, disease control and number of lesions were the only parameters significantly influencing survival (median 8.6 months), while disease-free survival was correlated with the number of isocenters. Seven percent of the patients presented severe complications, including nine episodes of radiation necrosis. The only parameter influencing the risk of radiation necrosis was the conformity index (p = 0.001). These findings emphasize the importance of reducing falsely irradiated normal tissue during radiosurgery to prevent radiation necrosis.</abstract><cop>Basel, Switzerland</cop><pmid>14742974</pmid><doi>10.1159/000075114</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 1011-6125 |
| ispartof | Stereotactic and functional neurosurgery, 2003-01, Vol.81 (1-4), p.115-119 |
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| source | Karger Journals; MEDLINE |
| subjects | Adult Aged Aged, 80 and over Alia Brain - pathology Brain Neoplasms - mortality Brain Neoplasms - pathology Brain Neoplasms - surgery Female Follow-Up Studies Humans Male Middle Aged Necrosis Postoperative Complications - mortality Postoperative Complications - pathology Predictive Value of Tests Radiation Dosage Radiosurgery - adverse effects Survival Analysis |
| title | Predictive Factors of Radiation Necrosis after Radiosurgery for Cerebral Metastases |
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