Prevention of Intrahepatic Metastasis by Curcumin in an Orthotopic Implantation Model

Curcumin has been shown to have potent anti-metastatic activity, however, its mechanism of action is still unclear. Here, we analyzed the anti-metastatic mechanism using hepatocellular carcinoma, CBO140C12 cells. Daily oral administration of curcumin suppressed intrahepatic metastasis in a dose-depe...

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Veröffentlicht in:	Oncology 2003-01, Vol.65 (3), p.250-258
Hauptverfasser:	Ohashi, Yasukata, Tsuchiya, Yasunori, Koizumi, Keiichi, Sakurai, Hiroaki, Saiki, Ikuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - metabolism Animals Antineoplastic Agents - therapeutic use Biological and medical sciences Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - prevention & control Carcinoma, Hepatocellular - secondary Cell Adhesion - drug effects Cell Movement - drug effects Clinical Study Curcumin - therapeutic use Disease Models, Animal Dose-Response Relationship, Drug Female Gastroenterology. Liver. Pancreas. Abdomen Humans Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver Neoplasms - prevention & control Liver Neoplasms - secondary Liver. Biliary tract. Portal circulation. Exocrine pancreas Matrix Metalloproteinase 9 - metabolism Medical sciences Mice Mice, Inbred C57BL Neoplasm Invasiveness Specific Pathogen-Free Organisms Tumor Cells, Cultured - transplantation Tumors
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