The Impact of Intestinal Ischaemia-Reperfusion on Caerulein-Induced Oedematous Experimental Pancreatitis
Background: Intestinal ischaemia is a feature of severe acute pancreatitis. It is not known whether intestinal ischaemia and reperfusion contributes to the progression from mild to severe pancreatitis. Aim: The aim of this study was to examine the impact of intestinal ischaemia-reperfusion on caerul...
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| Veröffentlicht in: | European surgical research 2003-07, Vol.35 (4), p.395-400 |
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| creator | Farrant, G.J. Abu-Zidan, F.M. Liu, X. Delahunt, B. Zwi, L.J. Windsor, J.A. |
| description | Background: Intestinal ischaemia is a feature of severe acute pancreatitis. It is not known whether intestinal ischaemia and reperfusion contributes to the progression from mild to severe pancreatitis. Aim: The aim of this study was to examine the impact of intestinal ischaemia-reperfusion on caerulein-induced oedematous experimental pancreatitis. Method: Male Wistar rats (n = 48) were randomised to 6 experimental groups: controls (CO), saline infusion (S), saline infusion and intestinal ischaemia-reperfusion (SIR), caerulein infusion (C), caerulein and sham operation (CS), and caerulein infusion with intestinal ischaemia reperfusion (CIR). Caerulein was infused over 6 h to induce mild oedematous pancreatitis. Clamping the superior mesenteric artery for 10 min induced mild intestinal ischaemia. The reperfusion time was 24 h. The primary end point was histology of the pancreas at 24 h. Results: There was no significant difference in histologic severity of pancreatitis at 24 h (Kruskal-Wallis, p = 0.37). Conclusion: The severity of acute oedematous pancreatitis was not increased by 10 min of intestinal ischaemia followed by 24 h of reperfusion. |
| doi_str_mv | 10.1159/000071331 |
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It is not known whether intestinal ischaemia and reperfusion contributes to the progression from mild to severe pancreatitis. Aim: The aim of this study was to examine the impact of intestinal ischaemia-reperfusion on caerulein-induced oedematous experimental pancreatitis. Method: Male Wistar rats (n = 48) were randomised to 6 experimental groups: controls (CO), saline infusion (S), saline infusion and intestinal ischaemia-reperfusion (SIR), caerulein infusion (C), caerulein and sham operation (CS), and caerulein infusion with intestinal ischaemia reperfusion (CIR). Caerulein was infused over 6 h to induce mild oedematous pancreatitis. Clamping the superior mesenteric artery for 10 min induced mild intestinal ischaemia. The reperfusion time was 24 h. The primary end point was histology of the pancreas at 24 h. Results: There was no significant difference in histologic severity of pancreatitis at 24 h (Kruskal-Wallis, p = 0.37). Conclusion: The severity of acute oedematous pancreatitis was not increased by 10 min of intestinal ischaemia followed by 24 h of reperfusion.</description><identifier>ISSN: 0014-312X</identifier><identifier>EISSN: 1421-9921</identifier><identifier>DOI: 10.1159/000071331</identifier><identifier>PMID: 12802103</identifier><identifier>CODEN: EUSRBM</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Acute Disease ; Animals ; Biological and medical sciences ; Ceruletide ; Edema - chemically induced ; Edema - complications ; Edema - pathology ; Gastroenterology. Liver. Pancreas. Abdomen ; Intestines - pathology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Mesenteric Arteries ; Oligopeptides - metabolism ; Original Paper ; Other diseases. Semiology ; Pancreas - pathology ; Pancreatitis - chemically induced ; Pancreatitis - complications ; Pancreatitis - pathology ; Rats ; Rats, Wistar ; Reperfusion Injury - complications ; Reperfusion Injury - pathology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surgical Instruments</subject><ispartof>European surgical research, 2003-07, Vol.35 (4), p.395-400</ispartof><rights>2003 S. Karger AG, Basel</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 S. Karger AG, Basel</rights><rights>Copyright (c) 2003 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-436276277f38cfc0fe2a6dd14ac0692cecca0197ae526b510dbdbdc1dad53c423</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14862891$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12802103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farrant, G.J.</creatorcontrib><creatorcontrib>Abu-Zidan, F.M.</creatorcontrib><creatorcontrib>Liu, X.</creatorcontrib><creatorcontrib>Delahunt, B.</creatorcontrib><creatorcontrib>Zwi, L.J.</creatorcontrib><creatorcontrib>Windsor, J.A.</creatorcontrib><title>The Impact of Intestinal Ischaemia-Reperfusion on Caerulein-Induced Oedematous Experimental Pancreatitis</title><title>European surgical research</title><addtitle>Eur Surg Res</addtitle><description>Background: Intestinal ischaemia is a feature of severe acute pancreatitis. It is not known whether intestinal ischaemia and reperfusion contributes to the progression from mild to severe pancreatitis. Aim: The aim of this study was to examine the impact of intestinal ischaemia-reperfusion on caerulein-induced oedematous experimental pancreatitis. Method: Male Wistar rats (n = 48) were randomised to 6 experimental groups: controls (CO), saline infusion (S), saline infusion and intestinal ischaemia-reperfusion (SIR), caerulein infusion (C), caerulein and sham operation (CS), and caerulein infusion with intestinal ischaemia reperfusion (CIR). Caerulein was infused over 6 h to induce mild oedematous pancreatitis. Clamping the superior mesenteric artery for 10 min induced mild intestinal ischaemia. The reperfusion time was 24 h. The primary end point was histology of the pancreas at 24 h. Results: There was no significant difference in histologic severity of pancreatitis at 24 h (Kruskal-Wallis, p = 0.37). Conclusion: The severity of acute oedematous pancreatitis was not increased by 10 min of intestinal ischaemia followed by 24 h of reperfusion.</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Ceruletide</subject><subject>Edema - chemically induced</subject><subject>Edema - complications</subject><subject>Edema - pathology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Intestines - pathology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesenteric Arteries</subject><subject>Oligopeptides - metabolism</subject><subject>Original Paper</subject><subject>Other diseases. Semiology</subject><subject>Pancreas - pathology</subject><subject>Pancreatitis - chemically induced</subject><subject>Pancreatitis - complications</subject><subject>Pancreatitis - pathology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reperfusion Injury - complications</subject><subject>Reperfusion Injury - pathology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Liver. Pancreas. Abdomen</topic><topic>Intestines - pathology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesenteric Arteries</topic><topic>Oligopeptides - metabolism</topic><topic>Original Paper</topic><topic>Other diseases. Semiology</topic><topic>Pancreas - pathology</topic><topic>Pancreatitis - chemically induced</topic><topic>Pancreatitis - complications</topic><topic>Pancreatitis - pathology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reperfusion Injury - complications</topic><topic>Reperfusion Injury - pathology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Surgical Instruments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farrant, G.J.</creatorcontrib><creatorcontrib>Abu-Zidan, F.M.</creatorcontrib><creatorcontrib>Liu, X.</creatorcontrib><creatorcontrib>Delahunt, B.</creatorcontrib><creatorcontrib>Zwi, L.J.</creatorcontrib><creatorcontrib>Windsor, J.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>European surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farrant, G.J.</au><au>Abu-Zidan, F.M.</au><au>Liu, X.</au><au>Delahunt, B.</au><au>Zwi, L.J.</au><au>Windsor, J.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Impact of Intestinal Ischaemia-Reperfusion on Caerulein-Induced Oedematous Experimental Pancreatitis</atitle><jtitle>European surgical research</jtitle><addtitle>Eur Surg Res</addtitle><date>2003-07-01</date><risdate>2003</risdate><volume>35</volume><issue>4</issue><spage>395</spage><epage>400</epage><pages>395-400</pages><issn>0014-312X</issn><eissn>1421-9921</eissn><coden>EUSRBM</coden><abstract>Background: Intestinal ischaemia is a feature of severe acute pancreatitis. It is not known whether intestinal ischaemia and reperfusion contributes to the progression from mild to severe pancreatitis. Aim: The aim of this study was to examine the impact of intestinal ischaemia-reperfusion on caerulein-induced oedematous experimental pancreatitis. Method: Male Wistar rats (n = 48) were randomised to 6 experimental groups: controls (CO), saline infusion (S), saline infusion and intestinal ischaemia-reperfusion (SIR), caerulein infusion (C), caerulein and sham operation (CS), and caerulein infusion with intestinal ischaemia reperfusion (CIR). Caerulein was infused over 6 h to induce mild oedematous pancreatitis. Clamping the superior mesenteric artery for 10 min induced mild intestinal ischaemia. The reperfusion time was 24 h. The primary end point was histology of the pancreas at 24 h. Results: There was no significant difference in histologic severity of pancreatitis at 24 h (Kruskal-Wallis, p = 0.37). Conclusion: The severity of acute oedematous pancreatitis was not increased by 10 min of intestinal ischaemia followed by 24 h of reperfusion.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>12802103</pmid><doi>10.1159/000071331</doi><tpages>6</tpages></addata></record> |
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| subjects | Acute Disease Animals Biological and medical sciences Ceruletide Edema - chemically induced Edema - complications Edema - pathology Gastroenterology. Liver. Pancreas. Abdomen Intestines - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Mesenteric Arteries Oligopeptides - metabolism Original Paper Other diseases. Semiology Pancreas - pathology Pancreatitis - chemically induced Pancreatitis - complications Pancreatitis - pathology Rats Rats, Wistar Reperfusion Injury - complications Reperfusion Injury - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surgical Instruments |
| title | The Impact of Intestinal Ischaemia-Reperfusion on Caerulein-Induced Oedematous Experimental Pancreatitis |
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