Role of Presurgical Gut Microbial Diversity in Roux-en-Y Gastric Bypass Weight-Loss Response: A Cohort Study

Abstract Introduction: Roux-en-Y gastric bypass (RYGB) substantially alters the gut microbial composition which could be associated with the metabolic improvements seen after surgery. Few studies have been conducted in Latin American populations, such as Mexico, where obesity prevalence is above 30%...

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Veröffentlicht in:Lifestyle genomics 2024-01, Vol.17 (1), p.12-21
Hauptverfasser: Morán-Ramos, Sofía, Soriano-Cortés, Ruth, Soto-Fuentes, Valeria, Tenorio-Quiroz, Amyris, Gervasio-Ortiz, Emmanuel, Rico-Amador, Dulce, Herrera, Miguel, Sierra-Salazar, Mauricio, Aguilar-Salinas, Carlos A., Antuna-Puente, Bárbara, Rodríguez-Flores, Marcela
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container_end_page 21
container_issue 1
container_start_page 12
container_title Lifestyle genomics
container_volume 17
creator Morán-Ramos, Sofía
Soriano-Cortés, Ruth
Soto-Fuentes, Valeria
Tenorio-Quiroz, Amyris
Gervasio-Ortiz, Emmanuel
Rico-Amador, Dulce
Herrera, Miguel
Sierra-Salazar, Mauricio
Aguilar-Salinas, Carlos A.
Antuna-Puente, Bárbara
Rodríguez-Flores, Marcela
description Abstract Introduction: Roux-en-Y gastric bypass (RYGB) substantially alters the gut microbial composition which could be associated with the metabolic improvements seen after surgery. Few studies have been conducted in Latin American populations, such as Mexico, where obesity prevalence is above 30% in the adult population. Thus, the aim of this study was to characterize the changes in the gut microbiota structure in a Mexican cohort before and after RYGB and to explore whether surgery-related changes in the microbial community were associated with weight loss. Methods: Biological samples from patients who underwent RYGB were examined before and 12 months after surgery. Fecal microbiota characterization was performed through 16S rRNA sequencing. Results: Twenty patients who underwent RYGB showed a median excess weight loss of 66.8% 12 months after surgery. Surgery increased alpha diversity estimates (Chao, Shannon index, and observed operational taxonomic units, p < 0.05) and significantly altered gut microbiota composition. Abundance of four genera was significantly increased after surgery: Oscillospira, Veillonella, Streptococcus, and an unclassified genus from Enterobacteriaceae family (PFDR < 0.1). The change in Veillonella abundance was associated with lower excess weight loss (rho = −0.446, p = 0.063) and its abundance post-surgery with a greater BMI (rho = 0.732, p = 5.4 × 10−4). In subjects without type 2 diabetes, lower bacterial richness and diversity before surgery were associated with a greater Veillonella increase after surgery (p < 0.05), suggesting that a lower bacterial richness before surgery could favor the bloom of certain oral-derived bacteria that could negatively impact weight loss. Conclusion: Presurgical microbiota profile may favor certain bacterial changes associated with less successful results.
doi_str_mv 10.1159/000535397
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Few studies have been conducted in Latin American populations, such as Mexico, where obesity prevalence is above 30% in the adult population. Thus, the aim of this study was to characterize the changes in the gut microbiota structure in a Mexican cohort before and after RYGB and to explore whether surgery-related changes in the microbial community were associated with weight loss. Methods: Biological samples from patients who underwent RYGB were examined before and 12 months after surgery. Fecal microbiota characterization was performed through 16S rRNA sequencing. Results: Twenty patients who underwent RYGB showed a median excess weight loss of 66.8% 12 months after surgery. Surgery increased alpha diversity estimates (Chao, Shannon index, and observed operational taxonomic units, p &lt; 0.05) and significantly altered gut microbiota composition. Abundance of four genera was significantly increased after surgery: Oscillospira, Veillonella, Streptococcus, and an unclassified genus from Enterobacteriaceae family (PFDR &lt; 0.1). The change in Veillonella abundance was associated with lower excess weight loss (rho = −0.446, p = 0.063) and its abundance post-surgery with a greater BMI (rho = 0.732, p = 5.4 × 10−4). In subjects without type 2 diabetes, lower bacterial richness and diversity before surgery were associated with a greater Veillonella increase after surgery (p &lt; 0.05), suggesting that a lower bacterial richness before surgery could favor the bloom of certain oral-derived bacteria that could negatively impact weight loss. 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Karger AG</publisher><subject>Abundance ; Adult ; Antihypertensives ; Bacteria ; Bacteria - genetics ; Biological properties ; Biological samples ; Blood pressure ; Calories ; Chronic illnesses ; Cohort Studies ; Composition ; Developing countries ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 ; Diet ; Discriminant analysis ; Fecal microflora ; Feces - microbiology ; Gastric bypass ; Gastric Bypass - methods ; Gastrointestinal Microbiome ; Gastrointestinal surgery ; Genera ; Glucose ; High density lipoprotein ; Humans ; Hypertension ; Intestinal microflora ; LDCs ; Metabolic disorders ; Microbiota ; Microorganisms ; Obesity ; Obesity, Morbid - microbiology ; Obesity, Morbid - surgery ; Ostomy ; Patients ; Population studies ; Remission (Medicine) ; Research Article ; RNA, Ribosomal, 16S - genetics ; rRNA 16S ; Surgery ; Triglycerides ; Weight ; Weight control ; Weight Loss ; Womens health</subject><ispartof>Lifestyle genomics, 2024-01, Vol.17 (1), p.12-21</ispartof><rights>2023 The Author(s). 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Few studies have been conducted in Latin American populations, such as Mexico, where obesity prevalence is above 30% in the adult population. Thus, the aim of this study was to characterize the changes in the gut microbiota structure in a Mexican cohort before and after RYGB and to explore whether surgery-related changes in the microbial community were associated with weight loss. Methods: Biological samples from patients who underwent RYGB were examined before and 12 months after surgery. Fecal microbiota characterization was performed through 16S rRNA sequencing. Results: Twenty patients who underwent RYGB showed a median excess weight loss of 66.8% 12 months after surgery. Surgery increased alpha diversity estimates (Chao, Shannon index, and observed operational taxonomic units, p &lt; 0.05) and significantly altered gut microbiota composition. Abundance of four genera was significantly increased after surgery: Oscillospira, Veillonella, Streptococcus, and an unclassified genus from Enterobacteriaceae family (PFDR &lt; 0.1). The change in Veillonella abundance was associated with lower excess weight loss (rho = −0.446, p = 0.063) and its abundance post-surgery with a greater BMI (rho = 0.732, p = 5.4 × 10−4). In subjects without type 2 diabetes, lower bacterial richness and diversity before surgery were associated with a greater Veillonella increase after surgery (p &lt; 0.05), suggesting that a lower bacterial richness before surgery could favor the bloom of certain oral-derived bacteria that could negatively impact weight loss. 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Few studies have been conducted in Latin American populations, such as Mexico, where obesity prevalence is above 30% in the adult population. Thus, the aim of this study was to characterize the changes in the gut microbiota structure in a Mexican cohort before and after RYGB and to explore whether surgery-related changes in the microbial community were associated with weight loss. Methods: Biological samples from patients who underwent RYGB were examined before and 12 months after surgery. Fecal microbiota characterization was performed through 16S rRNA sequencing. Results: Twenty patients who underwent RYGB showed a median excess weight loss of 66.8% 12 months after surgery. Surgery increased alpha diversity estimates (Chao, Shannon index, and observed operational taxonomic units, p &lt; 0.05) and significantly altered gut microbiota composition. Abundance of four genera was significantly increased after surgery: Oscillospira, Veillonella, Streptococcus, and an unclassified genus from Enterobacteriaceae family (PFDR &lt; 0.1). The change in Veillonella abundance was associated with lower excess weight loss (rho = −0.446, p = 0.063) and its abundance post-surgery with a greater BMI (rho = 0.732, p = 5.4 × 10−4). In subjects without type 2 diabetes, lower bacterial richness and diversity before surgery were associated with a greater Veillonella increase after surgery (p &lt; 0.05), suggesting that a lower bacterial richness before surgery could favor the bloom of certain oral-derived bacteria that could negatively impact weight loss. Conclusion: Presurgical microbiota profile may favor certain bacterial changes associated with less successful results.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>37992691</pmid><doi>10.1159/000535397</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
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subjects Abundance
Adult
Antihypertensives
Bacteria
Bacteria - genetics
Biological properties
Biological samples
Blood pressure
Calories
Chronic illnesses
Cohort Studies
Composition
Developing countries
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2
Diet
Discriminant analysis
Fecal microflora
Feces - microbiology
Gastric bypass
Gastric Bypass - methods
Gastrointestinal Microbiome
Gastrointestinal surgery
Genera
Glucose
High density lipoprotein
Humans
Hypertension
Intestinal microflora
LDCs
Metabolic disorders
Microbiota
Microorganisms
Obesity
Obesity, Morbid - microbiology
Obesity, Morbid - surgery
Ostomy
Patients
Population studies
Remission (Medicine)
Research Article
RNA, Ribosomal, 16S - genetics
rRNA 16S
Surgery
Triglycerides
Weight
Weight control
Weight Loss
Womens health
title Role of Presurgical Gut Microbial Diversity in Roux-en-Y Gastric Bypass Weight-Loss Response: A Cohort Study
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