Role of Presurgical Gut Microbial Diversity in Roux-en-Y Gastric Bypass Weight-Loss Response: A Cohort Study
Abstract Introduction: Roux-en-Y gastric bypass (RYGB) substantially alters the gut microbial composition which could be associated with the metabolic improvements seen after surgery. Few studies have been conducted in Latin American populations, such as Mexico, where obesity prevalence is above 30%...
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creator | Morán-Ramos, Sofía Soriano-Cortés, Ruth Soto-Fuentes, Valeria Tenorio-Quiroz, Amyris Gervasio-Ortiz, Emmanuel Rico-Amador, Dulce Herrera, Miguel Sierra-Salazar, Mauricio Aguilar-Salinas, Carlos A. Antuna-Puente, Bárbara Rodríguez-Flores, Marcela |
description | Abstract
Introduction: Roux-en-Y gastric bypass (RYGB) substantially alters the gut microbial composition which could be associated with the metabolic improvements seen after surgery. Few studies have been conducted in Latin American populations, such as Mexico, where obesity prevalence is above 30% in the adult population. Thus, the aim of this study was to characterize the changes in the gut microbiota structure in a Mexican cohort before and after RYGB and to explore whether surgery-related changes in the microbial community were associated with weight loss. Methods: Biological samples from patients who underwent RYGB were examined before and 12 months after surgery. Fecal microbiota characterization was performed through 16S rRNA sequencing. Results: Twenty patients who underwent RYGB showed a median excess weight loss of 66.8% 12 months after surgery. Surgery increased alpha diversity estimates (Chao, Shannon index, and observed operational taxonomic units, p < 0.05) and significantly altered gut microbiota composition. Abundance of four genera was significantly increased after surgery: Oscillospira, Veillonella, Streptococcus, and an unclassified genus from Enterobacteriaceae family (PFDR < 0.1). The change in Veillonella abundance was associated with lower excess weight loss (rho = −0.446, p = 0.063) and its abundance post-surgery with a greater BMI (rho = 0.732, p = 5.4 × 10−4). In subjects without type 2 diabetes, lower bacterial richness and diversity before surgery were associated with a greater Veillonella increase after surgery (p < 0.05), suggesting that a lower bacterial richness before surgery could favor the bloom of certain oral-derived bacteria that could negatively impact weight loss. Conclusion: Presurgical microbiota profile may favor certain bacterial changes associated with less successful results. |
doi_str_mv | 10.1159/000535397 |
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Introduction: Roux-en-Y gastric bypass (RYGB) substantially alters the gut microbial composition which could be associated with the metabolic improvements seen after surgery. Few studies have been conducted in Latin American populations, such as Mexico, where obesity prevalence is above 30% in the adult population. Thus, the aim of this study was to characterize the changes in the gut microbiota structure in a Mexican cohort before and after RYGB and to explore whether surgery-related changes in the microbial community were associated with weight loss. Methods: Biological samples from patients who underwent RYGB were examined before and 12 months after surgery. Fecal microbiota characterization was performed through 16S rRNA sequencing. Results: Twenty patients who underwent RYGB showed a median excess weight loss of 66.8% 12 months after surgery. Surgery increased alpha diversity estimates (Chao, Shannon index, and observed operational taxonomic units, p < 0.05) and significantly altered gut microbiota composition. Abundance of four genera was significantly increased after surgery: Oscillospira, Veillonella, Streptococcus, and an unclassified genus from Enterobacteriaceae family (PFDR < 0.1). The change in Veillonella abundance was associated with lower excess weight loss (rho = −0.446, p = 0.063) and its abundance post-surgery with a greater BMI (rho = 0.732, p = 5.4 × 10−4). In subjects without type 2 diabetes, lower bacterial richness and diversity before surgery were associated with a greater Veillonella increase after surgery (p < 0.05), suggesting that a lower bacterial richness before surgery could favor the bloom of certain oral-derived bacteria that could negatively impact weight loss. Conclusion: Presurgical microbiota profile may favor certain bacterial changes associated with less successful results.</description><identifier>ISSN: 2504-3161</identifier><identifier>ISSN: 2504-3188</identifier><identifier>EISSN: 2504-3188</identifier><identifier>DOI: 10.1159/000535397</identifier><identifier>PMID: 37992691</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Abundance ; Adult ; Antihypertensives ; Bacteria ; Bacteria - genetics ; Biological properties ; Biological samples ; Blood pressure ; Calories ; Chronic illnesses ; Cohort Studies ; Composition ; Developing countries ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 ; Diet ; Discriminant analysis ; Fecal microflora ; Feces - microbiology ; Gastric bypass ; Gastric Bypass - methods ; Gastrointestinal Microbiome ; Gastrointestinal surgery ; Genera ; Glucose ; High density lipoprotein ; Humans ; Hypertension ; Intestinal microflora ; LDCs ; Metabolic disorders ; Microbiota ; Microorganisms ; Obesity ; Obesity, Morbid - microbiology ; Obesity, Morbid - surgery ; Ostomy ; Patients ; Population studies ; Remission (Medicine) ; Research Article ; RNA, Ribosomal, 16S - genetics ; rRNA 16S ; Surgery ; Triglycerides ; Weight ; Weight control ; Weight Loss ; Womens health</subject><ispartof>Lifestyle genomics, 2024-01, Vol.17 (1), p.12-21</ispartof><rights>2023 The Author(s). Published by S. Karger AG, Basel</rights><rights>2023 The Author(s). Published by S. Karger AG, Basel.</rights><rights>2023 The Author(s). Published by S. Karger AG, Basel. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at: https://uk.sagepub.com/en-gb/eur/reusing-open-access-and-sage-choice-content</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27612,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37992691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morán-Ramos, Sofía</creatorcontrib><creatorcontrib>Soriano-Cortés, Ruth</creatorcontrib><creatorcontrib>Soto-Fuentes, Valeria</creatorcontrib><creatorcontrib>Tenorio-Quiroz, Amyris</creatorcontrib><creatorcontrib>Gervasio-Ortiz, Emmanuel</creatorcontrib><creatorcontrib>Rico-Amador, Dulce</creatorcontrib><creatorcontrib>Herrera, Miguel</creatorcontrib><creatorcontrib>Sierra-Salazar, Mauricio</creatorcontrib><creatorcontrib>Aguilar-Salinas, Carlos A.</creatorcontrib><creatorcontrib>Antuna-Puente, Bárbara</creatorcontrib><creatorcontrib>Rodríguez-Flores, Marcela</creatorcontrib><title>Role of Presurgical Gut Microbial Diversity in Roux-en-Y Gastric Bypass Weight-Loss Response: A Cohort Study</title><title>Lifestyle genomics</title><addtitle>Lifestyle Genomics</addtitle><description>Abstract
Introduction: Roux-en-Y gastric bypass (RYGB) substantially alters the gut microbial composition which could be associated with the metabolic improvements seen after surgery. Few studies have been conducted in Latin American populations, such as Mexico, where obesity prevalence is above 30% in the adult population. Thus, the aim of this study was to characterize the changes in the gut microbiota structure in a Mexican cohort before and after RYGB and to explore whether surgery-related changes in the microbial community were associated with weight loss. Methods: Biological samples from patients who underwent RYGB were examined before and 12 months after surgery. Fecal microbiota characterization was performed through 16S rRNA sequencing. Results: Twenty patients who underwent RYGB showed a median excess weight loss of 66.8% 12 months after surgery. Surgery increased alpha diversity estimates (Chao, Shannon index, and observed operational taxonomic units, p < 0.05) and significantly altered gut microbiota composition. Abundance of four genera was significantly increased after surgery: Oscillospira, Veillonella, Streptococcus, and an unclassified genus from Enterobacteriaceae family (PFDR < 0.1). The change in Veillonella abundance was associated with lower excess weight loss (rho = −0.446, p = 0.063) and its abundance post-surgery with a greater BMI (rho = 0.732, p = 5.4 × 10−4). In subjects without type 2 diabetes, lower bacterial richness and diversity before surgery were associated with a greater Veillonella increase after surgery (p < 0.05), suggesting that a lower bacterial richness before surgery could favor the bloom of certain oral-derived bacteria that could negatively impact weight loss. Conclusion: Presurgical microbiota profile may favor certain bacterial changes associated with less successful results.</description><subject>Abundance</subject><subject>Adult</subject><subject>Antihypertensives</subject><subject>Bacteria</subject><subject>Bacteria - genetics</subject><subject>Biological properties</subject><subject>Biological samples</subject><subject>Blood pressure</subject><subject>Calories</subject><subject>Chronic illnesses</subject><subject>Cohort Studies</subject><subject>Composition</subject><subject>Developing countries</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2</subject><subject>Diet</subject><subject>Discriminant analysis</subject><subject>Fecal microflora</subject><subject>Feces - microbiology</subject><subject>Gastric bypass</subject><subject>Gastric Bypass - methods</subject><subject>Gastrointestinal Microbiome</subject><subject>Gastrointestinal surgery</subject><subject>Genera</subject><subject>Glucose</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Intestinal microflora</subject><subject>LDCs</subject><subject>Metabolic disorders</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Obesity</subject><subject>Obesity, Morbid - microbiology</subject><subject>Obesity, Morbid - surgery</subject><subject>Ostomy</subject><subject>Patients</subject><subject>Population studies</subject><subject>Remission (Medicine)</subject><subject>Research Article</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>rRNA 16S</subject><subject>Surgery</subject><subject>Triglycerides</subject><subject>Weight</subject><subject>Weight control</subject><subject>Weight Loss</subject><subject>Womens health</subject><issn>2504-3161</issn><issn>2504-3188</issn><issn>2504-3188</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpt0c0vBDEUAPBGCIKDu0gTFw5DP6Y7UzcWS7JCFhGnSafzZpXZ6WhnxP73yjIHcepr3u-9vLyH0DYlh5QKeUQIEVxwmSyhdSZIHHGapst9PKBraMv7l8Co5DGL-Spa44mUbCDpOqomtgJsS3zrwHduarSq8Khr8bXRzuYm_M7MOzhv2jk2NZ7Y7iOCOnrCI-VbZzQ-nTfKe_wIZvrcRmMb4gn4xtYejvEJHtpn61p813bFfBOtlKrysPXzbqCHi_P74WU0vhldDU_GkeYiaaNcp7TMRclUoovvkXPOFGOCc62B01hSSiAv81hIXgomWcpSriQUhSiooHwD7S_6Ns6-deDbbGa8hqpSNdjOZyyVTMZpqAx07w99sZ2rw3QZJwkRRFIxCOpgocJOvHdQZo0zM-XmGSXZ1xWy_grB7v507PIZFL383XkAOwvwqtwUXA_6-r1_0-OL0UJkTVHyT0qZlKg</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Morán-Ramos, Sofía</creator><creator>Soriano-Cortés, Ruth</creator><creator>Soto-Fuentes, Valeria</creator><creator>Tenorio-Quiroz, Amyris</creator><creator>Gervasio-Ortiz, Emmanuel</creator><creator>Rico-Amador, Dulce</creator><creator>Herrera, Miguel</creator><creator>Sierra-Salazar, Mauricio</creator><creator>Aguilar-Salinas, Carlos A.</creator><creator>Antuna-Puente, Bárbara</creator><creator>Rodríguez-Flores, Marcela</creator><general>S. Karger AG</general><scope>M--</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M0K</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20240101</creationdate><title>Role of Presurgical Gut Microbial Diversity in Roux-en-Y Gastric Bypass Weight-Loss Response: A Cohort Study</title><author>Morán-Ramos, Sofía ; Soriano-Cortés, Ruth ; Soto-Fuentes, Valeria ; Tenorio-Quiroz, Amyris ; Gervasio-Ortiz, Emmanuel ; Rico-Amador, Dulce ; Herrera, Miguel ; Sierra-Salazar, Mauricio ; Aguilar-Salinas, Carlos A. ; Antuna-Puente, Bárbara ; Rodríguez-Flores, Marcela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-bc81fb5f2a7cd34243b32a22533cce3149110ebfb4593f52928283a9edd5d1513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abundance</topic><topic>Adult</topic><topic>Antihypertensives</topic><topic>Bacteria</topic><topic>Bacteria - genetics</topic><topic>Biological properties</topic><topic>Biological samples</topic><topic>Blood pressure</topic><topic>Calories</topic><topic>Chronic illnesses</topic><topic>Cohort Studies</topic><topic>Composition</topic><topic>Developing countries</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2</topic><topic>Diet</topic><topic>Discriminant analysis</topic><topic>Fecal microflora</topic><topic>Feces - microbiology</topic><topic>Gastric bypass</topic><topic>Gastric Bypass - methods</topic><topic>Gastrointestinal Microbiome</topic><topic>Gastrointestinal surgery</topic><topic>Genera</topic><topic>Glucose</topic><topic>High density lipoprotein</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Intestinal microflora</topic><topic>LDCs</topic><topic>Metabolic disorders</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Obesity</topic><topic>Obesity, Morbid - microbiology</topic><topic>Obesity, Morbid - surgery</topic><topic>Ostomy</topic><topic>Patients</topic><topic>Population studies</topic><topic>Remission (Medicine)</topic><topic>Research Article</topic><topic>RNA, Ribosomal, 16S - genetics</topic><topic>rRNA 16S</topic><topic>Surgery</topic><topic>Triglycerides</topic><topic>Weight</topic><topic>Weight control</topic><topic>Weight Loss</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morán-Ramos, Sofía</creatorcontrib><creatorcontrib>Soriano-Cortés, Ruth</creatorcontrib><creatorcontrib>Soto-Fuentes, Valeria</creatorcontrib><creatorcontrib>Tenorio-Quiroz, Amyris</creatorcontrib><creatorcontrib>Gervasio-Ortiz, Emmanuel</creatorcontrib><creatorcontrib>Rico-Amador, Dulce</creatorcontrib><creatorcontrib>Herrera, Miguel</creatorcontrib><creatorcontrib>Sierra-Salazar, Mauricio</creatorcontrib><creatorcontrib>Aguilar-Salinas, Carlos A.</creatorcontrib><creatorcontrib>Antuna-Puente, Bárbara</creatorcontrib><creatorcontrib>Rodríguez-Flores, Marcela</creatorcontrib><collection>Karger Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Agricultural Science Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Lifestyle genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morán-Ramos, Sofía</au><au>Soriano-Cortés, Ruth</au><au>Soto-Fuentes, Valeria</au><au>Tenorio-Quiroz, Amyris</au><au>Gervasio-Ortiz, Emmanuel</au><au>Rico-Amador, Dulce</au><au>Herrera, Miguel</au><au>Sierra-Salazar, Mauricio</au><au>Aguilar-Salinas, Carlos A.</au><au>Antuna-Puente, Bárbara</au><au>Rodríguez-Flores, Marcela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Presurgical Gut Microbial Diversity in Roux-en-Y Gastric Bypass Weight-Loss Response: A Cohort Study</atitle><jtitle>Lifestyle genomics</jtitle><addtitle>Lifestyle Genomics</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>17</volume><issue>1</issue><spage>12</spage><epage>21</epage><pages>12-21</pages><issn>2504-3161</issn><issn>2504-3188</issn><eissn>2504-3188</eissn><abstract>Abstract
Introduction: Roux-en-Y gastric bypass (RYGB) substantially alters the gut microbial composition which could be associated with the metabolic improvements seen after surgery. Few studies have been conducted in Latin American populations, such as Mexico, where obesity prevalence is above 30% in the adult population. Thus, the aim of this study was to characterize the changes in the gut microbiota structure in a Mexican cohort before and after RYGB and to explore whether surgery-related changes in the microbial community were associated with weight loss. Methods: Biological samples from patients who underwent RYGB were examined before and 12 months after surgery. Fecal microbiota characterization was performed through 16S rRNA sequencing. Results: Twenty patients who underwent RYGB showed a median excess weight loss of 66.8% 12 months after surgery. Surgery increased alpha diversity estimates (Chao, Shannon index, and observed operational taxonomic units, p < 0.05) and significantly altered gut microbiota composition. Abundance of four genera was significantly increased after surgery: Oscillospira, Veillonella, Streptococcus, and an unclassified genus from Enterobacteriaceae family (PFDR < 0.1). The change in Veillonella abundance was associated with lower excess weight loss (rho = −0.446, p = 0.063) and its abundance post-surgery with a greater BMI (rho = 0.732, p = 5.4 × 10−4). In subjects without type 2 diabetes, lower bacterial richness and diversity before surgery were associated with a greater Veillonella increase after surgery (p < 0.05), suggesting that a lower bacterial richness before surgery could favor the bloom of certain oral-derived bacteria that could negatively impact weight loss. Conclusion: Presurgical microbiota profile may favor certain bacterial changes associated with less successful results.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>37992691</pmid><doi>10.1159/000535397</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Abundance Adult Antihypertensives Bacteria Bacteria - genetics Biological properties Biological samples Blood pressure Calories Chronic illnesses Cohort Studies Composition Developing countries Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 Diet Discriminant analysis Fecal microflora Feces - microbiology Gastric bypass Gastric Bypass - methods Gastrointestinal Microbiome Gastrointestinal surgery Genera Glucose High density lipoprotein Humans Hypertension Intestinal microflora LDCs Metabolic disorders Microbiota Microorganisms Obesity Obesity, Morbid - microbiology Obesity, Morbid - surgery Ostomy Patients Population studies Remission (Medicine) Research Article RNA, Ribosomal, 16S - genetics rRNA 16S Surgery Triglycerides Weight Weight control Weight Loss Womens health |
title | Role of Presurgical Gut Microbial Diversity in Roux-en-Y Gastric Bypass Weight-Loss Response: A Cohort Study |
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