Platelet Function and Markers of Hemostatic Activation in Plasma Donors

Purpose: The aim of this study was to investigate the effects of plasmapheresis procedure on in vivo platelet activation, platelet function, blood coagulation, and fibrinolysis. Participants and Methods:16 healthy donors were subjected to automated plasma donation using cell separator Autopheresis C...

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Veröffentlicht in:Transfusion medicine and hemotherapy 1999, Vol.26 (6), p.344-347
Hauptverfasser: Vuk, T., Maglov, C., Godec, D., Tomicic, M., Balija, M., Grgicevic, D.
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container_end_page 347
container_issue 6
container_start_page 344
container_title Transfusion medicine and hemotherapy
container_volume 26
creator Vuk, T.
Maglov, C.
Godec, D.
Tomicic, M.
Balija, M.
Grgicevic, D.
description Purpose: The aim of this study was to investigate the effects of plasmapheresis procedure on in vivo platelet activation, platelet function, blood coagulation, and fibrinolysis. Participants and Methods:16 healthy donors were subjected to automated plasma donation using cell separator Autopheresis C®. 500 ml of plasma were collected per procedure. Samples of donors’ blood for routine hematological measurements and the measurement of P-selectin were obtained immediately before donation as well as 1 min, 24 h, and 48 h after donation. Fibrinogen concentrations, platelet aggregation, thrombin-antithrombin III (TAT) complexes and D dimers were measured before plasmapheresis as well as 1 min and 48 h after plasmapheresis. Results:Measurements of CD62-positive platelets and platelet aggregation using ADP, epinephrine, and arachidonic acid showed no significant differences between pre- and postdonation values (p > 0.05). Mean platelet volume (p < 0.01) as well as fibrinogen concentrations (p < 0.05) and D dimers (p
doi_str_mv 10.1159/000053517
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Participants and Methods:16 healthy donors were subjected to automated plasma donation using cell separator Autopheresis C®. 500 ml of plasma were collected per procedure. Samples of donors’ blood for routine hematological measurements and the measurement of P-selectin were obtained immediately before donation as well as 1 min, 24 h, and 48 h after donation. Fibrinogen concentrations, platelet aggregation, thrombin-antithrombin III (TAT) complexes and D dimers were measured before plasmapheresis as well as 1 min and 48 h after plasmapheresis. Results:Measurements of CD62-positive platelets and platelet aggregation using ADP, epinephrine, and arachidonic acid showed no significant differences between pre- and postdonation values (p &gt; 0.05). Mean platelet volume (p &lt; 0.01) as well as fibrinogen concentrations (p &lt; 0.05) and D dimers (p &lt;0.05) were reduced after plasmapheresis. Plasma concentrations of circulating TAT complexes increased signifi-cantly after plasmapheresis (p &lt; 0.001). Concentrations of fibrinogen and TAT complexes returned to the baseline values within 48 h while concentrations of D dimers remained lower 48 h after the completition of the procedure. Conclusion:On the basis of the evaluated testing there was no evidence that plasmapheresis adversely affected platelet-dependent primary hemostasis. Decreased concentrations of D dimers after plasmapheresis suggest no increase in fibrinolytic activity. Nonspecific loss of circulating D dimers during the procedure is a likely explanation. Observed changes of coagulation parameters suggest that plasmapheresis procedure has a transient influence on hemostasis, probably without clinical significance.</description><identifier>ISSN: 1660-3796</identifier><identifier>EISSN: 1660-3818</identifier><identifier>DOI: 10.1159/000053517</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Original Article · Originalarbeit</subject><ispartof>Transfusion medicine and hemotherapy, 1999, Vol.26 (6), p.344-347</ispartof><rights>1999 S. Karger GmbH, Freiburg</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,2423,4010,27904,27905,27906</link.rule.ids></links><search><creatorcontrib>Vuk, T.</creatorcontrib><creatorcontrib>Maglov, C.</creatorcontrib><creatorcontrib>Godec, D.</creatorcontrib><creatorcontrib>Tomicic, M.</creatorcontrib><creatorcontrib>Balija, M.</creatorcontrib><creatorcontrib>Grgicevic, D.</creatorcontrib><title>Platelet Function and Markers of Hemostatic Activation in Plasma Donors</title><title>Transfusion medicine and hemotherapy</title><addtitle>Transfus Med Hemother</addtitle><description>Purpose: The aim of this study was to investigate the effects of plasmapheresis procedure on in vivo platelet activation, platelet function, blood coagulation, and fibrinolysis. Participants and Methods:16 healthy donors were subjected to automated plasma donation using cell separator Autopheresis C®. 500 ml of plasma were collected per procedure. Samples of donors’ blood for routine hematological measurements and the measurement of P-selectin were obtained immediately before donation as well as 1 min, 24 h, and 48 h after donation. Fibrinogen concentrations, platelet aggregation, thrombin-antithrombin III (TAT) complexes and D dimers were measured before plasmapheresis as well as 1 min and 48 h after plasmapheresis. Results:Measurements of CD62-positive platelets and platelet aggregation using ADP, epinephrine, and arachidonic acid showed no significant differences between pre- and postdonation values (p &gt; 0.05). Mean platelet volume (p &lt; 0.01) as well as fibrinogen concentrations (p &lt; 0.05) and D dimers (p &lt;0.05) were reduced after plasmapheresis. Plasma concentrations of circulating TAT complexes increased signifi-cantly after plasmapheresis (p &lt; 0.001). Concentrations of fibrinogen and TAT complexes returned to the baseline values within 48 h while concentrations of D dimers remained lower 48 h after the completition of the procedure. Conclusion:On the basis of the evaluated testing there was no evidence that plasmapheresis adversely affected platelet-dependent primary hemostasis. Decreased concentrations of D dimers after plasmapheresis suggest no increase in fibrinolytic activity. Nonspecific loss of circulating D dimers during the procedure is a likely explanation. 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Participants and Methods:16 healthy donors were subjected to automated plasma donation using cell separator Autopheresis C®. 500 ml of plasma were collected per procedure. Samples of donors’ blood for routine hematological measurements and the measurement of P-selectin were obtained immediately before donation as well as 1 min, 24 h, and 48 h after donation. Fibrinogen concentrations, platelet aggregation, thrombin-antithrombin III (TAT) complexes and D dimers were measured before plasmapheresis as well as 1 min and 48 h after plasmapheresis. Results:Measurements of CD62-positive platelets and platelet aggregation using ADP, epinephrine, and arachidonic acid showed no significant differences between pre- and postdonation values (p &gt; 0.05). Mean platelet volume (p &lt; 0.01) as well as fibrinogen concentrations (p &lt; 0.05) and D dimers (p &lt;0.05) were reduced after plasmapheresis. Plasma concentrations of circulating TAT complexes increased signifi-cantly after plasmapheresis (p &lt; 0.001). Concentrations of fibrinogen and TAT complexes returned to the baseline values within 48 h while concentrations of D dimers remained lower 48 h after the completition of the procedure. Conclusion:On the basis of the evaluated testing there was no evidence that plasmapheresis adversely affected platelet-dependent primary hemostasis. Decreased concentrations of D dimers after plasmapheresis suggest no increase in fibrinolytic activity. Nonspecific loss of circulating D dimers during the procedure is a likely explanation. Observed changes of coagulation parameters suggest that plasmapheresis procedure has a transient influence on hemostasis, probably without clinical significance.</abstract><cop>Basel, Switzerland</cop><doi>10.1159/000053517</doi><tpages>4</tpages></addata></record>
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title Platelet Function and Markers of Hemostatic Activation in Plasma Donors
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