The Potential Role of Environmental Toxins in the Pathophysiology of Endometriosis
Environmental contaminants that are known to disrupt steroid action can influence the development of reproductive diseases. Our group has focused on whether 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin) can disrupt steroid regulation of endometrial matrix metalloproteinase (MMP) expression. T...
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| Veröffentlicht in: | Gynecologic and obstetric investigation 1999-01, Vol.48 (Suppl 1), p.45-56 |
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| container_issue | Suppl 1 |
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| container_title | Gynecologic and obstetric investigation |
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| creator | Bruner-Tran, Kaylon L. Rier, Sherry E. Eisenberg, Esther Osteen, Kevin G. |
| description | Environmental contaminants that are known to disrupt steroid action can influence the development of reproductive diseases. Our group has focused on whether 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin) can disrupt steroid regulation of endometrial matrix metalloproteinase (MMP) expression. The MMPs regulate extracellular matrix turnover in normal tissues, but the inappropriate expression of these enzymes is associated with numerous disease states that involve invasive processes. We have previously shown that secretion of MMPs by human endometrium is critical for establishment of ectopic lesions in a nude mouse model of experimental endometriosis. In this report, we show that TCDD exposure promotes establishment of experimental endometriosis by interfering with the ability of progesterone to suppress endometrial MMP expression. |
| doi_str_mv | 10.1159/000052868 |
| format | Article |
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Our group has focused on whether 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin) can disrupt steroid regulation of endometrial matrix metalloproteinase (MMP) expression. The MMPs regulate extracellular matrix turnover in normal tissues, but the inappropriate expression of these enzymes is associated with numerous disease states that involve invasive processes. We have previously shown that secretion of MMPs by human endometrium is critical for establishment of ectopic lesions in a nude mouse model of experimental endometriosis. In this report, we show that TCDD exposure promotes establishment of experimental endometriosis by interfering with the ability of progesterone to suppress endometrial MMP expression.</description><identifier>ISSN: 0378-7346</identifier><identifier>ISBN: 3805569874</identifier><identifier>ISBN: 9783805569873</identifier><identifier>EISSN: 1423-002X</identifier><identifier>EISBN: 9783318005202</identifier><identifier>EISBN: 3318005207</identifier><identifier>DOI: 10.1159/000052868</identifier><identifier>PMID: 10559664</identifier><identifier>CODEN: GOBIDS</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Animals ; Biological and medical sciences ; Blotting, Western ; Cell Communication - drug effects ; Endometriosis ; Endometriosis - etiology ; Endometriosis - physiopathology ; Endometrium - drug effects ; Endometrium - pathology ; Environmental Exposure - adverse effects ; Environmental Pollutants - adverse effects ; Environmental Pollutants - toxicity ; Estradiol - physiology ; Female ; Female genital diseases ; Gene Expression Regulation - drug effects ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Matrix Metalloproteinases - physiology ; Medical sciences ; Mice ; Mice, Nude ; Non tumoral diseases ; Polychlorinated Dibenzodioxins - adverse effects ; Polychlorinated Dibenzodioxins - toxicity ; Progesterone - physiology ; Session 3: Review ; Transforming Growth Factor beta - analysis</subject><ispartof>Gynecologic and obstetric investigation, 1999-01, Vol.48 (Suppl 1), p.45-56</ispartof><rights>1999 S. Karger AG, Basel</rights><rights>1999 INIST-CNRS</rights><rights>Copyright (c) 1999 S. 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Our group has focused on whether 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin) can disrupt steroid regulation of endometrial matrix metalloproteinase (MMP) expression. The MMPs regulate extracellular matrix turnover in normal tissues, but the inappropriate expression of these enzymes is associated with numerous disease states that involve invasive processes. We have previously shown that secretion of MMPs by human endometrium is critical for establishment of ectopic lesions in a nude mouse model of experimental endometriosis. 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| identifier | ISSN: 0378-7346 |
| ispartof | Gynecologic and obstetric investigation, 1999-01, Vol.48 (Suppl 1), p.45-56 |
| issn | 0378-7346 1423-002X |
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| recordid | cdi_karger_primary_52868 |
| source | Karger Journals; MEDLINE |
| subjects | Adult Animals Biological and medical sciences Blotting, Western Cell Communication - drug effects Endometriosis Endometriosis - etiology Endometriosis - physiopathology Endometrium - drug effects Endometrium - pathology Environmental Exposure - adverse effects Environmental Pollutants - adverse effects Environmental Pollutants - toxicity Estradiol - physiology Female Female genital diseases Gene Expression Regulation - drug effects Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Matrix Metalloproteinases - physiology Medical sciences Mice Mice, Nude Non tumoral diseases Polychlorinated Dibenzodioxins - adverse effects Polychlorinated Dibenzodioxins - toxicity Progesterone - physiology Session 3: Review Transforming Growth Factor beta - analysis |
| title | The Potential Role of Environmental Toxins in the Pathophysiology of Endometriosis |
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