Histopathological Landscape of Precursor Lesions of Gastro-Entero-Pancreatic Neuroendocrine Neoplasms
Abstract Background: Despite the important advances in research on neuroendocrine neoplasms of the gastro-entero-pancreatic tract, their precursor lesions are much less well known. Summary: This review analyzes the preneoplastic neuroendocrine lesions of the gastro-entero-pancreatic tract, by adopti...
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| Veröffentlicht in: | Digestive diseases (Basel) 2023-01, Vol.41 (1), p.34-48 |
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| creator | Biancotti, Rachele Dal Pozzo, Carlo Alberto Parente, Paola Businello, Gianluca Angerilli, Valentina Realdon, Stefano Savarino, Edoardo Vincenzo Farinati, Fabio Milanetto, Anna Caterina Pasquali, Claudio Vettor, Roberto Grillo, Federica Pennelli, Gianmaria Luchini, Claudio Mastracci, Luca Vanoli, Alessandro Milione, Massimo Galuppini, Francesca Fassan, Matteo |
| description | Abstract
Background: Despite the important advances in research on neuroendocrine neoplasms of the gastro-entero-pancreatic tract, their precursor lesions are much less well known. Summary: This review analyzes the preneoplastic neuroendocrine lesions of the gastro-entero-pancreatic tract, by adopting a coherent anatomical benchmark. In particular, the settings in which neuroendocrine precursor lesions represent well-recognized pathophysiological and morphological entities (with eventual molecular correlates) have been distinguished from the ones in which the nature of preneoplastic changes is still obscure. Key Messages: The aim of the paper was to summarize what is known about precursor lesions of gastro-entero-pancreatic neuroendocrine tumors, with the goal of providing a useful tool for future research aimed at obtaining a fuller understanding of the underlying biology and early development of these diseases. |
| doi_str_mv | 10.1159/000525421 |
| format | Article |
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Background: Despite the important advances in research on neuroendocrine neoplasms of the gastro-entero-pancreatic tract, their precursor lesions are much less well known. Summary: This review analyzes the preneoplastic neuroendocrine lesions of the gastro-entero-pancreatic tract, by adopting a coherent anatomical benchmark. In particular, the settings in which neuroendocrine precursor lesions represent well-recognized pathophysiological and morphological entities (with eventual molecular correlates) have been distinguished from the ones in which the nature of preneoplastic changes is still obscure. Key Messages: The aim of the paper was to summarize what is known about precursor lesions of gastro-entero-pancreatic neuroendocrine tumors, with the goal of providing a useful tool for future research aimed at obtaining a fuller understanding of the underlying biology and early development of these diseases.</description><identifier>ISSN: 0257-2753</identifier><identifier>EISSN: 1421-9875</identifier><identifier>DOI: 10.1159/000525421</identifier><identifier>PMID: 35816999</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Humans ; Intestinal Neoplasms - pathology ; Neuroendocrine Tumors - pathology ; Pancreas - pathology ; Pancreatic Neoplasms - pathology ; Stomach and Duodenum: Review Article ; Stomach Neoplasms - pathology</subject><ispartof>Digestive diseases (Basel), 2023-01, Vol.41 (1), p.34-48</ispartof><rights>2022 S. Karger AG, Basel</rights><rights>2022 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c341t-f83f81666ac2e31f11a19f379812a799f8e3316f5bbea66f5760c0a0ccd4bb833</citedby><cites>FETCH-LOGICAL-c341t-f83f81666ac2e31f11a19f379812a799f8e3316f5bbea66f5760c0a0ccd4bb833</cites><orcidid>0000-0003-0193-5281 ; 0000-0003-0591-6723 ; 0000-0002-0365-5286 ; 0000-0001-6515-5482</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,4010,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35816999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Biancotti, Rachele</creatorcontrib><creatorcontrib>Dal Pozzo, Carlo Alberto</creatorcontrib><creatorcontrib>Parente, Paola</creatorcontrib><creatorcontrib>Businello, Gianluca</creatorcontrib><creatorcontrib>Angerilli, Valentina</creatorcontrib><creatorcontrib>Realdon, Stefano</creatorcontrib><creatorcontrib>Savarino, Edoardo Vincenzo</creatorcontrib><creatorcontrib>Farinati, Fabio</creatorcontrib><creatorcontrib>Milanetto, Anna Caterina</creatorcontrib><creatorcontrib>Pasquali, Claudio</creatorcontrib><creatorcontrib>Vettor, Roberto</creatorcontrib><creatorcontrib>Grillo, Federica</creatorcontrib><creatorcontrib>Pennelli, Gianmaria</creatorcontrib><creatorcontrib>Luchini, Claudio</creatorcontrib><creatorcontrib>Mastracci, Luca</creatorcontrib><creatorcontrib>Vanoli, Alessandro</creatorcontrib><creatorcontrib>Milione, Massimo</creatorcontrib><creatorcontrib>Galuppini, Francesca</creatorcontrib><creatorcontrib>Fassan, Matteo</creatorcontrib><title>Histopathological Landscape of Precursor Lesions of Gastro-Entero-Pancreatic Neuroendocrine Neoplasms</title><title>Digestive diseases (Basel)</title><addtitle>Dig Dis</addtitle><description>Abstract
Background: Despite the important advances in research on neuroendocrine neoplasms of the gastro-entero-pancreatic tract, their precursor lesions are much less well known. Summary: This review analyzes the preneoplastic neuroendocrine lesions of the gastro-entero-pancreatic tract, by adopting a coherent anatomical benchmark. In particular, the settings in which neuroendocrine precursor lesions represent well-recognized pathophysiological and morphological entities (with eventual molecular correlates) have been distinguished from the ones in which the nature of preneoplastic changes is still obscure. 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Background: Despite the important advances in research on neuroendocrine neoplasms of the gastro-entero-pancreatic tract, their precursor lesions are much less well known. Summary: This review analyzes the preneoplastic neuroendocrine lesions of the gastro-entero-pancreatic tract, by adopting a coherent anatomical benchmark. In particular, the settings in which neuroendocrine precursor lesions represent well-recognized pathophysiological and morphological entities (with eventual molecular correlates) have been distinguished from the ones in which the nature of preneoplastic changes is still obscure. Key Messages: The aim of the paper was to summarize what is known about precursor lesions of gastro-entero-pancreatic neuroendocrine tumors, with the goal of providing a useful tool for future research aimed at obtaining a fuller understanding of the underlying biology and early development of these diseases.</abstract><cop>Basel, Switzerland</cop><pmid>35816999</pmid><doi>10.1159/000525421</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0003-0193-5281</orcidid><orcidid>https://orcid.org/0000-0003-0591-6723</orcidid><orcidid>https://orcid.org/0000-0002-0365-5286</orcidid><orcidid>https://orcid.org/0000-0001-6515-5482</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0257-2753 |
| ispartof | Digestive diseases (Basel), 2023-01, Vol.41 (1), p.34-48 |
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| language | eng |
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| source | Karger Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Humans Intestinal Neoplasms - pathology Neuroendocrine Tumors - pathology Pancreas - pathology Pancreatic Neoplasms - pathology Stomach and Duodenum: Review Article Stomach Neoplasms - pathology |
| title | Histopathological Landscape of Precursor Lesions of Gastro-Entero-Pancreatic Neuroendocrine Neoplasms |
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