Preoperative Plasma Aldosterone Predicts Complete Remission of Type 2 Diabetes after Bariatric Surgery
Introduction: Bariatric surgery (BS) has beneficial effects on body weight and type 2 diabetes. However, 44–52%, 20–40%, and 19–25% of patients with type 2 diabetes who undergo sleeve gastrectomy, sleeve gastrectomy with duodenal-jejunal bypass, and Roux-en-Y gastric bypass, respectively, show insuf...
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| Veröffentlicht in: | Obesity facts 2022, Vol.15 (3), p.373-383 |
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| creator | Ohira, Masahiro Abe, Kazuki Yamaguchi, Takashi Onda, Hiroki Yamaoka, Shuhei Nakamura, Shoko Tanaka, Shou Watanabe, Yasuhiro Nabekura, Taiki Oshiro, Takashi Nagayama, Daiji Saiki, Atsuhito Tatsuno, Ichiro |
| description | Introduction: Bariatric surgery (BS) has beneficial effects on body weight and type 2 diabetes. However, 44–52%, 20–40%, and 19–25% of patients with type 2 diabetes who undergo sleeve gastrectomy, sleeve gastrectomy with duodenal-jejunal bypass, and Roux-en-Y gastric bypass, respectively, show insufficient improvement 1 year after BS. It is thus important to predict the improvement in type 2 diabetes before BS. Many hormones are related to hyperglycemia. However, the relationship between hormones and improvement in type 2 diabetes after BS has not been studied. We aimed to evaluate the relationship between the improvement in type 2 diabetes and hormones in patients with obesity and type 2 diabetes who underwent BS. Methods: We retrospectively reviewed 79 patients with obesity and type 2 diabetes who underwent BS, with a follow-up period of 12 months. We analyzed the relationship between some clinical parameters and complete remission (CR) of type 2 diabetes after BS. Patients were divided into two groups (type 2 diabetes CR and non-CR). Multiple regression analysis was performed to determine the parameters associated with type 2 diabetes resolution after BS. Results: BS significantly improved body weight and glucose metabolism. Preoperative liver function, glycated hemoglobin (HbA1c), insulin secretion (homeostatic model assessment [HOMA]2-%B), renin activity, plasma aldosterone level, and duration of type 2 diabetes were significantly different between the CR and non-CR groups. Multiple regression analysis showed that preoperative HbA1c, HOMA2-%B, aldosterone concentration, and duration of type 2 diabetes were predictors of CR of type 2 diabetes after BS. Plasma aldosterone was the strongest predictor. Discussion/Conclusion: Preoperative plasma aldosterone levels were related to the CR of type 2 diabetes after BS. Measuring plasma aldosterone levels preoperatively is useful for predicting the CR of type 2 diabetes after BS. |
| doi_str_mv | 10.1159/000521855 |
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However, 44–52%, 20–40%, and 19–25% of patients with type 2 diabetes who undergo sleeve gastrectomy, sleeve gastrectomy with duodenal-jejunal bypass, and Roux-en-Y gastric bypass, respectively, show insufficient improvement 1 year after BS. It is thus important to predict the improvement in type 2 diabetes before BS. Many hormones are related to hyperglycemia. However, the relationship between hormones and improvement in type 2 diabetes after BS has not been studied. We aimed to evaluate the relationship between the improvement in type 2 diabetes and hormones in patients with obesity and type 2 diabetes who underwent BS. Methods: We retrospectively reviewed 79 patients with obesity and type 2 diabetes who underwent BS, with a follow-up period of 12 months. We analyzed the relationship between some clinical parameters and complete remission (CR) of type 2 diabetes after BS. Patients were divided into two groups (type 2 diabetes CR and non-CR). Multiple regression analysis was performed to determine the parameters associated with type 2 diabetes resolution after BS. Results: BS significantly improved body weight and glucose metabolism. Preoperative liver function, glycated hemoglobin (HbA1c), insulin secretion (homeostatic model assessment [HOMA]2-%B), renin activity, plasma aldosterone level, and duration of type 2 diabetes were significantly different between the CR and non-CR groups. Multiple regression analysis showed that preoperative HbA1c, HOMA2-%B, aldosterone concentration, and duration of type 2 diabetes were predictors of CR of type 2 diabetes after BS. Plasma aldosterone was the strongest predictor. Discussion/Conclusion: Preoperative plasma aldosterone levels were related to the CR of type 2 diabetes after BS. Measuring plasma aldosterone levels preoperatively is useful for predicting the CR of type 2 diabetes after BS.</description><identifier>ISSN: 1662-4025</identifier><identifier>EISSN: 1662-4033</identifier><identifier>DOI: 10.1159/000521855</identifier><identifier>PMID: 35016181</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>bariatric surgery ; Cholesterol ; Creatinine ; Diabetes ; diabetes remission ; Gastrointestinal surgery ; Glucose ; Hormones ; Immunoassay ; Insulin resistance ; Insulin-like growth factors ; Metabolism ; Obesity ; Peptides ; Plasma ; plasma aldosterone concentration ; Reagents ; Regression analysis ; Remission (Medicine) ; Research Article ; Software ; type 2 diabetes ; Weight control</subject><ispartof>Obesity facts, 2022, Vol.15 (3), p.373-383</ispartof><rights>2022 The Author(s). Published by S. Karger AG, Basel</rights><rights>2022 The Author(s). Published by S. 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Karger AG, Basel 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4215-a559d069ddca02984f857cdff099e70481d9405783d6c763ff617bb9f351ec8d3</cites><orcidid>0000-0002-7200-7952 ; 0000-0002-9614-162X ; 0000-0003-4009-9386 ; 0000-0002-1935-6125</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209993/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209993/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,4010,27612,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35016181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohira, Masahiro</creatorcontrib><creatorcontrib>Abe, Kazuki</creatorcontrib><creatorcontrib>Yamaguchi, Takashi</creatorcontrib><creatorcontrib>Onda, Hiroki</creatorcontrib><creatorcontrib>Yamaoka, Shuhei</creatorcontrib><creatorcontrib>Nakamura, Shoko</creatorcontrib><creatorcontrib>Tanaka, Shou</creatorcontrib><creatorcontrib>Watanabe, Yasuhiro</creatorcontrib><creatorcontrib>Nabekura, Taiki</creatorcontrib><creatorcontrib>Oshiro, Takashi</creatorcontrib><creatorcontrib>Nagayama, Daiji</creatorcontrib><creatorcontrib>Saiki, Atsuhito</creatorcontrib><creatorcontrib>Tatsuno, Ichiro</creatorcontrib><title>Preoperative Plasma Aldosterone Predicts Complete Remission of Type 2 Diabetes after Bariatric Surgery</title><title>Obesity facts</title><addtitle>Obes Facts</addtitle><description>Introduction: Bariatric surgery (BS) has beneficial effects on body weight and type 2 diabetes. However, 44–52%, 20–40%, and 19–25% of patients with type 2 diabetes who undergo sleeve gastrectomy, sleeve gastrectomy with duodenal-jejunal bypass, and Roux-en-Y gastric bypass, respectively, show insufficient improvement 1 year after BS. It is thus important to predict the improvement in type 2 diabetes before BS. Many hormones are related to hyperglycemia. However, the relationship between hormones and improvement in type 2 diabetes after BS has not been studied. We aimed to evaluate the relationship between the improvement in type 2 diabetes and hormones in patients with obesity and type 2 diabetes who underwent BS. Methods: We retrospectively reviewed 79 patients with obesity and type 2 diabetes who underwent BS, with a follow-up period of 12 months. We analyzed the relationship between some clinical parameters and complete remission (CR) of type 2 diabetes after BS. Patients were divided into two groups (type 2 diabetes CR and non-CR). Multiple regression analysis was performed to determine the parameters associated with type 2 diabetes resolution after BS. Results: BS significantly improved body weight and glucose metabolism. Preoperative liver function, glycated hemoglobin (HbA1c), insulin secretion (homeostatic model assessment [HOMA]2-%B), renin activity, plasma aldosterone level, and duration of type 2 diabetes were significantly different between the CR and non-CR groups. Multiple regression analysis showed that preoperative HbA1c, HOMA2-%B, aldosterone concentration, and duration of type 2 diabetes were predictors of CR of type 2 diabetes after BS. Plasma aldosterone was the strongest predictor. Discussion/Conclusion: Preoperative plasma aldosterone levels were related to the CR of type 2 diabetes after BS. Measuring plasma aldosterone levels preoperatively is useful for predicting the CR of type 2 diabetes after BS.</description><subject>bariatric surgery</subject><subject>Cholesterol</subject><subject>Creatinine</subject><subject>Diabetes</subject><subject>diabetes remission</subject><subject>Gastrointestinal surgery</subject><subject>Glucose</subject><subject>Hormones</subject><subject>Immunoassay</subject><subject>Insulin resistance</subject><subject>Insulin-like growth factors</subject><subject>Metabolism</subject><subject>Obesity</subject><subject>Peptides</subject><subject>Plasma</subject><subject>plasma aldosterone concentration</subject><subject>Reagents</subject><subject>Regression analysis</subject><subject>Remission (Medicine)</subject><subject>Research Article</subject><subject>Software</subject><subject>type 2 diabetes</subject><subject>Weight control</subject><issn>1662-4025</issn><issn>1662-4033</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>DOA</sourceid><recordid>eNptksFu1DAQQCMEoqVw4I6QJS5wWBg7sRNfkJaFQqVKraCcLcceL16ycbCTSvv3eNklUMTJ1szzm9GMi-IphdeUcvkGADijDef3ilMqBFtUUJb35zvjJ8WjlDYAglY1fViclByooA09Ldx1xDBg1KO_RXLd6bTVZNnZkEaMoc-hiNabMZFV2A4djkg-49an5ENPgiM3uwEJI--9bnMuEe3yO_JOR6_H6A35MsU1xt3j4oHTXcInx_Os-Hr-4Wb1aXF59fFitbxcmIpRvtCcSwtCWms0MNlUruG1sc6BlFhD1VArK-B1U1phalE6J2jdttKVnKJpbHlWXBy8NuiNGqLf6rhTQXv1KxDiWuk4etOhEg04w1relpWrWmm0MNrp2giQgNDW2fX24BqmdovWYD9G3d2R3s30_ptah1slWW5Xllnw8iiI4ceEaVR5cAa7TvcYpqSYoDKvLfee0Rf_oJswxT6PSjEJUDLBm73w1YEyMaQU0c3NUFD7n6Dmn5DZ5393P5O_V_-n5He9X9EMXJ0vDwo1WJepZ_-ljlV-AlQUwy4</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Ohira, Masahiro</creator><creator>Abe, Kazuki</creator><creator>Yamaguchi, Takashi</creator><creator>Onda, Hiroki</creator><creator>Yamaoka, Shuhei</creator><creator>Nakamura, Shoko</creator><creator>Tanaka, Shou</creator><creator>Watanabe, Yasuhiro</creator><creator>Nabekura, Taiki</creator><creator>Oshiro, Takashi</creator><creator>Nagayama, Daiji</creator><creator>Saiki, Atsuhito</creator><creator>Tatsuno, Ichiro</creator><general>S. 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Plasma Aldosterone Predicts Complete Remission of Type 2 Diabetes after Bariatric Surgery</title><author>Ohira, Masahiro ; Abe, Kazuki ; Yamaguchi, Takashi ; Onda, Hiroki ; Yamaoka, Shuhei ; Nakamura, Shoko ; Tanaka, Shou ; Watanabe, Yasuhiro ; Nabekura, Taiki ; Oshiro, Takashi ; Nagayama, Daiji ; Saiki, Atsuhito ; Tatsuno, Ichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4215-a559d069ddca02984f857cdff099e70481d9405783d6c763ff617bb9f351ec8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>bariatric surgery</topic><topic>Cholesterol</topic><topic>Creatinine</topic><topic>Diabetes</topic><topic>diabetes remission</topic><topic>Gastrointestinal surgery</topic><topic>Glucose</topic><topic>Hormones</topic><topic>Immunoassay</topic><topic>Insulin resistance</topic><topic>Insulin-like growth factors</topic><topic>Metabolism</topic><topic>Obesity</topic><topic>Peptides</topic><topic>Plasma</topic><topic>plasma aldosterone concentration</topic><topic>Reagents</topic><topic>Regression analysis</topic><topic>Remission (Medicine)</topic><topic>Research Article</topic><topic>Software</topic><topic>type 2 diabetes</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohira, Masahiro</creatorcontrib><creatorcontrib>Abe, Kazuki</creatorcontrib><creatorcontrib>Yamaguchi, Takashi</creatorcontrib><creatorcontrib>Onda, Hiroki</creatorcontrib><creatorcontrib>Yamaoka, Shuhei</creatorcontrib><creatorcontrib>Nakamura, Shoko</creatorcontrib><creatorcontrib>Tanaka, Shou</creatorcontrib><creatorcontrib>Watanabe, Yasuhiro</creatorcontrib><creatorcontrib>Nabekura, Taiki</creatorcontrib><creatorcontrib>Oshiro, Takashi</creatorcontrib><creatorcontrib>Nagayama, Daiji</creatorcontrib><creatorcontrib>Saiki, 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China</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ABI/INFORM Collection China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Obesity facts</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohira, Masahiro</au><au>Abe, Kazuki</au><au>Yamaguchi, Takashi</au><au>Onda, Hiroki</au><au>Yamaoka, Shuhei</au><au>Nakamura, Shoko</au><au>Tanaka, Shou</au><au>Watanabe, Yasuhiro</au><au>Nabekura, Taiki</au><au>Oshiro, Takashi</au><au>Nagayama, Daiji</au><au>Saiki, Atsuhito</au><au>Tatsuno, Ichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative Plasma Aldosterone Predicts Complete Remission of Type 2 Diabetes after Bariatric Surgery</atitle><jtitle>Obesity facts</jtitle><addtitle>Obes Facts</addtitle><date>2022</date><risdate>2022</risdate><volume>15</volume><issue>3</issue><spage>373</spage><epage>383</epage><pages>373-383</pages><issn>1662-4025</issn><eissn>1662-4033</eissn><abstract>Introduction: Bariatric surgery (BS) has beneficial effects on body weight and type 2 diabetes. However, 44–52%, 20–40%, and 19–25% of patients with type 2 diabetes who undergo sleeve gastrectomy, sleeve gastrectomy with duodenal-jejunal bypass, and Roux-en-Y gastric bypass, respectively, show insufficient improvement 1 year after BS. It is thus important to predict the improvement in type 2 diabetes before BS. Many hormones are related to hyperglycemia. However, the relationship between hormones and improvement in type 2 diabetes after BS has not been studied. We aimed to evaluate the relationship between the improvement in type 2 diabetes and hormones in patients with obesity and type 2 diabetes who underwent BS. Methods: We retrospectively reviewed 79 patients with obesity and type 2 diabetes who underwent BS, with a follow-up period of 12 months. We analyzed the relationship between some clinical parameters and complete remission (CR) of type 2 diabetes after BS. Patients were divided into two groups (type 2 diabetes CR and non-CR). Multiple regression analysis was performed to determine the parameters associated with type 2 diabetes resolution after BS. Results: BS significantly improved body weight and glucose metabolism. Preoperative liver function, glycated hemoglobin (HbA1c), insulin secretion (homeostatic model assessment [HOMA]2-%B), renin activity, plasma aldosterone level, and duration of type 2 diabetes were significantly different between the CR and non-CR groups. Multiple regression analysis showed that preoperative HbA1c, HOMA2-%B, aldosterone concentration, and duration of type 2 diabetes were predictors of CR of type 2 diabetes after BS. Plasma aldosterone was the strongest predictor. Discussion/Conclusion: Preoperative plasma aldosterone levels were related to the CR of type 2 diabetes after BS. Measuring plasma aldosterone levels preoperatively is useful for predicting the CR of type 2 diabetes after BS.</abstract><cop>Basel, Switzerland</cop><pub>S. 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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Karger Open Access |
| subjects | bariatric surgery Cholesterol Creatinine Diabetes diabetes remission Gastrointestinal surgery Glucose Hormones Immunoassay Insulin resistance Insulin-like growth factors Metabolism Obesity Peptides Plasma plasma aldosterone concentration Reagents Regression analysis Remission (Medicine) Research Article Software type 2 diabetes Weight control |
| title | Preoperative Plasma Aldosterone Predicts Complete Remission of Type 2 Diabetes after Bariatric Surgery |
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