Hyperoxalemia Leads to Oxidative Stress in Endothelial Cells and Mice with Chronic Kidney Disease

Introduction: Cardiovascular disease is the most common cause of morbidity and mortality in patients with ESRD. In addition to phosphate overload, oxalate, a common uremic toxin, is also involved in vascular calcification in patients with ESRD. The present study investigated the role and mechanism o...

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Veröffentlicht in:	Kidney & blood pressure research 2021-06, Vol.46 (3), p.377-386
Hauptverfasser:	Sun, Ke, Tang, Xiaojing, Song, Shuwei, Gao, Yuan, Yu, Hongjing, Sun, Ningyun, Wen, Bin, Mei, Changlin
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Aorta Apolipoprotein E Arteriosclerosis Atherosclerosis Blood pressure Calcification Calcification (ectopic) Cardiovascular diseases Chromatography Chronic kidney failure Correlation analysis Development and progression Diagnosis Electrocoagulation end-stage renal disease Endothelial cells Experiments Hemodialysis hyperoxalemia Inflammation Interleukin 6 Kidney diseases Kidneys Malondialdehyde Markers Measurement Morbidity Mortality Muscles Overloading Oxalic acid Oxaluria Oxidation Oxidative stress Penicillin Reduction Research Article Risk factors Serum levels Smooth muscle Superoxide dismutase Toxins Tumor necrosis factor-α Uremia vascular calcification
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