Treatment Strategy for Pancreatic Head Cancer: Pylorus-Preserving Pancreatoduodenectomy, Intraoperative Radiotherapy and Portal Catheterization
Pancreatic cancer is the disease of gastrointestinal cancer with the poorest prognosis. At present, in addition to surgery, multimodality treatment combining a variety of therapeutic methods is used. We usually employ the following combination of surgery, radiotherapy and chemotherapy: D2 surgery wi...
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| Veröffentlicht in: | Digestion 1999-01, Vol.60 (Suppl 1), p.130-134 |
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| container_issue | Suppl 1 |
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| container_title | Digestion |
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| creator | Takahashi, Shin Aiura, Kouichi Saitoh, Junichi Hayatsu, Sigeo Kitajima, Masaki Ogata, Yoshiro |
| description | Pancreatic cancer is the disease of gastrointestinal cancer with the poorest prognosis. At present, in addition to surgery, multimodality treatment combining a variety of therapeutic methods is used. We usually employ the following combination of surgery, radiotherapy and chemotherapy: D2 surgery with pylorus-preserving pancreatoduodenectomy (PPPD), intraoperative radiotherapy (IORT), and portal catheterization (PC) with fluorouracil as the chemotherapy. In this study, we made a historical comparison of PPPD and PD and obtained the following findings: (1) PPPD allows almost the same extent of D2 dissection as conventional PD, and achieves radical treatment without any problems; (2) suppression of local recurrence by IORT cannot be expected from the results of the comparison between the four approaches, i.e. surgery alone, surgery + IORT, surgery + PC and surgery + IORT + PC, and (3) the rate of liver metastasis in patients treated by PC was significantly low. |
| doi_str_mv | 10.1159/000051469 |
| format | Article |
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At present, in addition to surgery, multimodality treatment combining a variety of therapeutic methods is used. We usually employ the following combination of surgery, radiotherapy and chemotherapy: D2 surgery with pylorus-preserving pancreatoduodenectomy (PPPD), intraoperative radiotherapy (IORT), and portal catheterization (PC) with fluorouracil as the chemotherapy. In this study, we made a historical comparison of PPPD and PD and obtained the following findings: (1) PPPD allows almost the same extent of D2 dissection as conventional PD, and achieves radical treatment without any problems; (2) suppression of local recurrence by IORT cannot be expected from the results of the comparison between the four approaches, i.e. surgery alone, surgery + IORT, surgery + PC and surgery + IORT + PC, and (3) the rate of liver metastasis in patients treated by PC was significantly low.</description><identifier>ISSN: 0012-2823</identifier><identifier>ISBN: 3805568428</identifier><identifier>ISBN: 9783805568425</identifier><identifier>EISSN: 1421-9867</identifier><identifier>EISBN: 9783318004090</identifier><identifier>EISBN: 331800409X</identifier><identifier>DOI: 10.1159/000051469</identifier><identifier>PMID: 10026447</identifier><identifier>CODEN: DIGEBW</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Biological and medical sciences ; Catheterization ; Combined Modality Therapy ; Humans ; Intraoperative Care ; Liver, biliary tract, pancreas, portal circulation, spleen ; Medical sciences ; Neoplasm Recurrence, Local ; Pancreatic CancerPancreatic Cancer Surgery Today: Japanese Experience ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - radiotherapy ; Pancreatic Neoplasms - surgery ; Pancreaticoduodenectomy ; Portal Vein - surgery ; Prognosis ; Pylorus - pathology ; Pylorus - surgery ; Retrospective Studies ; Surgery (general aspects). 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At present, in addition to surgery, multimodality treatment combining a variety of therapeutic methods is used. We usually employ the following combination of surgery, radiotherapy and chemotherapy: D2 surgery with pylorus-preserving pancreatoduodenectomy (PPPD), intraoperative radiotherapy (IORT), and portal catheterization (PC) with fluorouracil as the chemotherapy. In this study, we made a historical comparison of PPPD and PD and obtained the following findings: (1) PPPD allows almost the same extent of D2 dissection as conventional PD, and achieves radical treatment without any problems; (2) suppression of local recurrence by IORT cannot be expected from the results of the comparison between the four approaches, i.e. surgery alone, surgery + IORT, surgery + PC and surgery + IORT + PC, and (3) the rate of liver metastasis in patients treated by PC was significantly low.</description><subject>Biological and medical sciences</subject><subject>Catheterization</subject><subject>Combined Modality Therapy</subject><subject>Humans</subject><subject>Intraoperative Care</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Medical sciences</subject><subject>Neoplasm Recurrence, Local</subject><subject>Pancreatic CancerPancreatic Cancer Surgery Today: Japanese Experience</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - radiotherapy</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Pancreaticoduodenectomy</subject><subject>Portal Vein - surgery</subject><subject>Prognosis</subject><subject>Pylorus - pathology</subject><subject>Pylorus - surgery</subject><subject>Retrospective Studies</subject><subject>Surgery (general aspects). 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Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takahashi, Shin</creatorcontrib><creatorcontrib>Aiura, Kouichi</creatorcontrib><creatorcontrib>Saitoh, Junichi</creatorcontrib><creatorcontrib>Hayatsu, Sigeo</creatorcontrib><creatorcontrib>Kitajima, Masaki</creatorcontrib><creatorcontrib>Ogata, Yoshiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Digestion</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takahashi, Shin</au><au>Aiura, Kouichi</au><au>Saitoh, Junichi</au><au>Hayatsu, Sigeo</au><au>Kitajima, Masaki</au><au>Ogata, Yoshiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment Strategy for Pancreatic Head Cancer: Pylorus-Preserving Pancreatoduodenectomy, Intraoperative Radiotherapy and Portal Catheterization</atitle><jtitle>Digestion</jtitle><addtitle>Digestion</addtitle><date>1999-01-01</date><risdate>1999</risdate><volume>60</volume><issue>Suppl 1</issue><spage>130</spage><epage>134</epage><pages>130-134</pages><issn>0012-2823</issn><eissn>1421-9867</eissn><isbn>3805568428</isbn><isbn>9783805568425</isbn><eisbn>9783318004090</eisbn><eisbn>331800409X</eisbn><coden>DIGEBW</coden><abstract>Pancreatic cancer is the disease of gastrointestinal cancer with the poorest prognosis. At present, in addition to surgery, multimodality treatment combining a variety of therapeutic methods is used. We usually employ the following combination of surgery, radiotherapy and chemotherapy: D2 surgery with pylorus-preserving pancreatoduodenectomy (PPPD), intraoperative radiotherapy (IORT), and portal catheterization (PC) with fluorouracil as the chemotherapy. In this study, we made a historical comparison of PPPD and PD and obtained the following findings: (1) PPPD allows almost the same extent of D2 dissection as conventional PD, and achieves radical treatment without any problems; (2) suppression of local recurrence by IORT cannot be expected from the results of the comparison between the four approaches, i.e. surgery alone, surgery + IORT, surgery + PC and surgery + IORT + PC, and (3) the rate of liver metastasis in patients treated by PC was significantly low.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>10026447</pmid><doi>10.1159/000051469</doi><tpages>5</tpages></addata></record> |
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| ispartof | Digestion, 1999-01, Vol.60 (Suppl 1), p.130-134 |
| issn | 0012-2823 1421-9867 |
| language | eng |
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| source | MEDLINE; Karger Journals |
| subjects | Biological and medical sciences Catheterization Combined Modality Therapy Humans Intraoperative Care Liver, biliary tract, pancreas, portal circulation, spleen Medical sciences Neoplasm Recurrence, Local Pancreatic CancerPancreatic Cancer Surgery Today: Japanese Experience Pancreatic Neoplasms - pathology Pancreatic Neoplasms - radiotherapy Pancreatic Neoplasms - surgery Pancreaticoduodenectomy Portal Vein - surgery Prognosis Pylorus - pathology Pylorus - surgery Retrospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Treatment Outcome |
| title | Treatment Strategy for Pancreatic Head Cancer: Pylorus-Preserving Pancreatoduodenectomy, Intraoperative Radiotherapy and Portal Catheterization |
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