Critical Review of Acid Suppression in Nonvariceal, Acute, Upper Gastrointestinal Bleeding

Nonvariceal, upper gastrointestinal (GI) bleeding is a very common source of morbidity and mortality. The concept of ulcer clot dissolution being facilitated by a low gastric pH has allowed us to better understand the pathophysiology of nonvariceal upper GI bleeding. Placebo-controlled trials have s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Digestive diseases (Basel) 2000-01, Vol.18 (3), p.117-128
Hauptverfasser:	Yacyshyn, B.R., Thomson, A.B.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Review Article
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	128
container_issue	3
container_start_page	117
container_title	Digestive diseases (Basel)
container_volume	18
creator	Yacyshyn, B.R. Thomson, A.B.R.
description	Nonvariceal, upper gastrointestinal (GI) bleeding is a very common source of morbidity and mortality. The concept of ulcer clot dissolution being facilitated by a low gastric pH has allowed us to better understand the pathophysiology of nonvariceal upper GI bleeding. Placebo-controlled trials have shown the benefit of oral proton pump inhibitor administration in contrast to H 2 receptor antagonists. Furthermore, our recent experience with intravenous proton pump inhibitors has reinforced these observations.
doi_str_mv	10.1159/000051385
format	Article
fullrecord	<record><control><sourceid>karger_cross</sourceid><recordid>TN_cdi_karger_primary_51385</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>51385</sourcerecordid><originalsourceid>FETCH-LOGICAL-c274t-709e11ef30c75ca4e51d46f8fca9529d676d4b1262c956ea3815bd221d7e294a3</originalsourceid><addsrcrecordid>eNpt0DtPwzAUBWALgWgpDMwsFhtSA37EcTyWFkqlCiSgC0vk2teVISSRnRbx7wkUOnGXO5xPZzgInVJySalQV6Q7QXku9lCfpowmKpdiH_UJEzJhUvAeOorxlZAOy-wQ9ShlUnFO-uhlHHzrjS7xI2w8fODa4ZHxFj-tmyZAjL6usK_wfV1tdPAGdDnswLqFIV40DQQ81bENta9aiK2vuqLrEsD6anWMDpwuI5z8_gFa3N48j--S-cN0Nh7NE8Nk2iaSKKAUHCdGCqNTENSmmcud0UowZTOZ2XRJWcaMEhlonlOxtIxRK4GpVPMButj2mlDHGMAVTfDvOnwWlBTf-xS7fTp7trVvOqwg7ORfev5vOpnMfkDRWMe_AFcnamQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Critical Review of Acid Suppression in Nonvariceal, Acute, Upper Gastrointestinal Bleeding</title><source>Karger Journals</source><source>Alma/SFX Local Collection</source><creator>Yacyshyn, B.R. ; Thomson, A.B.R.</creator><creatorcontrib>Yacyshyn, B.R. ; Thomson, A.B.R.</creatorcontrib><description>Nonvariceal, upper gastrointestinal (GI) bleeding is a very common source of morbidity and mortality. The concept of ulcer clot dissolution being facilitated by a low gastric pH has allowed us to better understand the pathophysiology of nonvariceal upper GI bleeding. Placebo-controlled trials have shown the benefit of oral proton pump inhibitor administration in contrast to H 2 receptor antagonists. Furthermore, our recent experience with intravenous proton pump inhibitors has reinforced these observations.</description><identifier>ISSN: 0257-2753</identifier><identifier>EISSN: 1421-9875</identifier><identifier>DOI: 10.1159/000051385</identifier><identifier>PMID: 11279330</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Review Article</subject><ispartof>Digestive diseases (Basel), 2000-01, Vol.18 (3), p.117-128</ispartof><rights>2001 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c274t-709e11ef30c75ca4e51d46f8fca9529d676d4b1262c956ea3815bd221d7e294a3</citedby><cites>FETCH-LOGICAL-c274t-709e11ef30c75ca4e51d46f8fca9529d676d4b1262c956ea3815bd221d7e294a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2428,27923,27924</link.rule.ids></links><search><creatorcontrib>Yacyshyn, B.R.</creatorcontrib><creatorcontrib>Thomson, A.B.R.</creatorcontrib><title>Critical Review of Acid Suppression in Nonvariceal, Acute, Upper Gastrointestinal Bleeding</title><title>Digestive diseases (Basel)</title><addtitle>Dig Dis</addtitle><description>Nonvariceal, upper gastrointestinal (GI) bleeding is a very common source of morbidity and mortality. The concept of ulcer clot dissolution being facilitated by a low gastric pH has allowed us to better understand the pathophysiology of nonvariceal upper GI bleeding. Placebo-controlled trials have shown the benefit of oral proton pump inhibitor administration in contrast to H 2 receptor antagonists. Furthermore, our recent experience with intravenous proton pump inhibitors has reinforced these observations.</description><subject>Review Article</subject><issn>0257-2753</issn><issn>1421-9875</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNpt0DtPwzAUBWALgWgpDMwsFhtSA37EcTyWFkqlCiSgC0vk2teVISSRnRbx7wkUOnGXO5xPZzgInVJySalQV6Q7QXku9lCfpowmKpdiH_UJEzJhUvAeOorxlZAOy-wQ9ShlUnFO-uhlHHzrjS7xI2w8fODa4ZHxFj-tmyZAjL6usK_wfV1tdPAGdDnswLqFIV40DQQ81bENta9aiK2vuqLrEsD6anWMDpwuI5z8_gFa3N48j--S-cN0Nh7NE8Nk2iaSKKAUHCdGCqNTENSmmcud0UowZTOZ2XRJWcaMEhlonlOxtIxRK4GpVPMButj2mlDHGMAVTfDvOnwWlBTf-xS7fTp7trVvOqwg7ORfev5vOpnMfkDRWMe_AFcnamQ</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>Yacyshyn, B.R.</creator><creator>Thomson, A.B.R.</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20000101</creationdate><title>Critical Review of Acid Suppression in Nonvariceal, Acute, Upper Gastrointestinal Bleeding</title><author>Yacyshyn, B.R. ; Thomson, A.B.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c274t-709e11ef30c75ca4e51d46f8fca9529d676d4b1262c956ea3815bd221d7e294a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Review Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yacyshyn, B.R.</creatorcontrib><creatorcontrib>Thomson, A.B.R.</creatorcontrib><collection>CrossRef</collection><jtitle>Digestive diseases (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yacyshyn, B.R.</au><au>Thomson, A.B.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Critical Review of Acid Suppression in Nonvariceal, Acute, Upper Gastrointestinal Bleeding</atitle><jtitle>Digestive diseases (Basel)</jtitle><addtitle>Dig Dis</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>18</volume><issue>3</issue><spage>117</spage><epage>128</epage><pages>117-128</pages><issn>0257-2753</issn><eissn>1421-9875</eissn><abstract>Nonvariceal, upper gastrointestinal (GI) bleeding is a very common source of morbidity and mortality. The concept of ulcer clot dissolution being facilitated by a low gastric pH has allowed us to better understand the pathophysiology of nonvariceal upper GI bleeding. Placebo-controlled trials have shown the benefit of oral proton pump inhibitor administration in contrast to H 2 receptor antagonists. Furthermore, our recent experience with intravenous proton pump inhibitors has reinforced these observations.</abstract><cop>Basel, Switzerland</cop><pmid>11279330</pmid><doi>10.1159/000051385</doi><tpages>12</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0257-2753
ispartof	Digestive diseases (Basel), 2000-01, Vol.18 (3), p.117-128
issn	0257-2753 1421-9875
language	eng
recordid	cdi_karger_primary_51385
source	Karger Journals; Alma/SFX Local Collection
subjects	Review Article
title	Critical Review of Acid Suppression in Nonvariceal, Acute, Upper Gastrointestinal Bleeding
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T13%3A17%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-karger_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Critical%20Review%20of%20Acid%20Suppression%20in%20Nonvariceal,%20Acute,%20Upper%20Gastrointestinal%20Bleeding&rft.jtitle=Digestive%20diseases%20(Basel)&rft.au=Yacyshyn,%20B.R.&rft.date=2000-01-01&rft.volume=18&rft.issue=3&rft.spage=117&rft.epage=128&rft.pages=117-128&rft.issn=0257-2753&rft.eissn=1421-9875&rft_id=info:doi/10.1159/000051385&rft_dat=%3Ckarger_cross%3E51385%3C/karger_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/11279330&rfr_iscdi=true