Body Mass Index Predicts Decline in Executive Function in Bipolar Disorder: Preliminary Data of a 12-Month Follow-up Study
Introduction: Obesity and associated risk factors have been linked to cognitive decline before. Objectives: In the present study, we evaluated potential cumulative negative effects of overweight and obesity on cognitive performance in euthymic patients with bipolar disorder (BD) in a longitudinal de...
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| Veröffentlicht in: | Neuropsychobiology 2021-01, Vol.80 (1), p.1-11 |
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| creator | Dalkner, Nina Bengesser, Susanne Birner, Armin Rieger, Alexandra Seebauer, Julia Platzer, Martina Hamm, Carlo Maget, Alexander Queissner, Robert Pilz, René Fellendorf, Frederike T. Reininghaus, Bernd Strassnig, Martin T. Kapfhammer, Hans-Peter Weiss, Elisabeth M. Reininghaus, Eva Z. |
| description | Introduction: Obesity and associated risk factors have been linked to cognitive decline before. Objectives: In the present study, we evaluated potential cumulative negative effects of overweight and obesity on cognitive performance in euthymic patients with bipolar disorder (BD) in a longitudinal design. Methods: Neurocognitive measures (California Verbal Learning Test, Trail Making Test [TMT] A/B, Digit-Symbol-Test, Digit-Span, d2 Test), anthropometrics (e.g., body mass index [BMI]), and clinical ratings (Hamilton Depression Scale, Young Mania Rating Scale) were collected over a 12-month observation period. Follow-up data of 38 patients with BD (mean age 40 years; 15 males, 23 females) were available. Results: High baseline BMI predicted a decrease in the patient’s performance in the Digit-Span backwards task measuring working memory performance. In contrast, cognitive performance was not predicted by increases in BMI at follow-up. Normal weight bipolar patients (n = 19) improved their performance on the TMT B, measuring cognitive flexibility and executive functioning, within 1 year, while overweight bipolar patients (n = 19) showed no change in this task. Conclusions: The results suggest that overweight can predict cognitive performance changes over 12 months. |
| doi_str_mv | 10.1159/000505784 |
| format | Article |
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Objectives: In the present study, we evaluated potential cumulative negative effects of overweight and obesity on cognitive performance in euthymic patients with bipolar disorder (BD) in a longitudinal design. Methods: Neurocognitive measures (California Verbal Learning Test, Trail Making Test [TMT] A/B, Digit-Symbol-Test, Digit-Span, d2 Test), anthropometrics (e.g., body mass index [BMI]), and clinical ratings (Hamilton Depression Scale, Young Mania Rating Scale) were collected over a 12-month observation period. Follow-up data of 38 patients with BD (mean age 40 years; 15 males, 23 females) were available. Results: High baseline BMI predicted a decrease in the patient’s performance in the Digit-Span backwards task measuring working memory performance. In contrast, cognitive performance was not predicted by increases in BMI at follow-up. Normal weight bipolar patients (n = 19) improved their performance on the TMT B, measuring cognitive flexibility and executive functioning, within 1 year, while overweight bipolar patients (n = 19) showed no change in this task. Conclusions: The results suggest that overweight can predict cognitive performance changes over 12 months.</description><identifier>ISSN: 0302-282X</identifier><identifier>EISSN: 1423-0224</identifier><identifier>DOI: 10.1159/000505784</identifier><identifier>PMID: 32454501</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Life Sciences & Biomedicine ; Neurosciences ; Neurosciences & Neurology ; Psychiatry ; Psychology ; Research Article ; Science & Technology ; Social Sciences</subject><ispartof>Neuropsychobiology, 2021-01, Vol.80 (1), p.1-11</ispartof><rights>2020 S. Karger AG, Basel</rights><rights>2020 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>7</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000614767900001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c388t-7ad6237b749e80ce3d5d4038a92e5aa375a57d462f550e5c6ef8ef42ff2227af3</citedby><cites>FETCH-LOGICAL-c388t-7ad6237b749e80ce3d5d4038a92e5aa375a57d462f550e5c6ef8ef42ff2227af3</cites><orcidid>0000-0001-7215-3848 ; 0000-0003-1296-3448</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,2433,27933,27934,39266,39267</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32454501$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dalkner, Nina</creatorcontrib><creatorcontrib>Bengesser, Susanne</creatorcontrib><creatorcontrib>Birner, Armin</creatorcontrib><creatorcontrib>Rieger, Alexandra</creatorcontrib><creatorcontrib>Seebauer, Julia</creatorcontrib><creatorcontrib>Platzer, Martina</creatorcontrib><creatorcontrib>Hamm, Carlo</creatorcontrib><creatorcontrib>Maget, Alexander</creatorcontrib><creatorcontrib>Queissner, Robert</creatorcontrib><creatorcontrib>Pilz, René</creatorcontrib><creatorcontrib>Fellendorf, Frederike T.</creatorcontrib><creatorcontrib>Reininghaus, Bernd</creatorcontrib><creatorcontrib>Strassnig, Martin T.</creatorcontrib><creatorcontrib>Kapfhammer, Hans-Peter</creatorcontrib><creatorcontrib>Weiss, Elisabeth M.</creatorcontrib><creatorcontrib>Reininghaus, Eva Z.</creatorcontrib><title>Body Mass Index Predicts Decline in Executive Function in Bipolar Disorder: Preliminary Data of a 12-Month Follow-up Study</title><title>Neuropsychobiology</title><addtitle>NEUROPSYCHOBIOLOGY</addtitle><addtitle>Neuropsychobiology</addtitle><description>Introduction: Obesity and associated risk factors have been linked to cognitive decline before. Objectives: In the present study, we evaluated potential cumulative negative effects of overweight and obesity on cognitive performance in euthymic patients with bipolar disorder (BD) in a longitudinal design. Methods: Neurocognitive measures (California Verbal Learning Test, Trail Making Test [TMT] A/B, Digit-Symbol-Test, Digit-Span, d2 Test), anthropometrics (e.g., body mass index [BMI]), and clinical ratings (Hamilton Depression Scale, Young Mania Rating Scale) were collected over a 12-month observation period. Follow-up data of 38 patients with BD (mean age 40 years; 15 males, 23 females) were available. Results: High baseline BMI predicted a decrease in the patient’s performance in the Digit-Span backwards task measuring working memory performance. In contrast, cognitive performance was not predicted by increases in BMI at follow-up. Normal weight bipolar patients (n = 19) improved their performance on the TMT B, measuring cognitive flexibility and executive functioning, within 1 year, while overweight bipolar patients (n = 19) showed no change in this task. Conclusions: The results suggest that overweight can predict cognitive performance changes over 12 months.</description><subject>Life Sciences & Biomedicine</subject><subject>Neurosciences</subject><subject>Neurosciences & Neurology</subject><subject>Psychiatry</subject><subject>Psychology</subject><subject>Research Article</subject><subject>Science & Technology</subject><subject>Social Sciences</subject><issn>0302-282X</issn><issn>1423-0224</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>GIZIO</sourceid><sourceid>HGBXW</sourceid><recordid>eNqNkE1v1DAURSMEotPCgj1CltgUoYA_44QdnelApRYqFSR2kcd-BkPGDrZDO_x6EmWYFQvkhS3r3Kv3TlE8IfgVIaJ5jTEWWMia3ysWhFNWYkr5_WKBGaYlremXo-I4pe8YE97I5mFxxCgXXGCyKH6fBbNDVyoldOEN3KHrCMbpnNAKdOc8IOfR-R3oIbtfgNaD19kFP_2euT50KqKVSyEaiG-mbOe2zqu4QyuVFQoWKURoeRV8_obWoevCbTn06CYPZveoeGBVl-Dx_j4pPq_PPy3fl5cf310s316WmtV1LqUyFWVyI3kDNdbAjDAcs1o1FIRSTAolpOEVtUJgELoCW4Pl1FpKqVSWnRSnc28fw88BUm63LmnoOuUhDKmlHEtGxtOM6IsZ1TGkFMG2fXTbcZ2W4HZS3R5Uj-yzfe2w2YI5kH_djkA9A7ewCTZpB17DARuLKsJlJZvxhcnSZTWJXYbB5zH68v-jI_18pn-o-BXigftwfTPP2vZm0vD0n9R-nT871q4E</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Dalkner, Nina</creator><creator>Bengesser, Susanne</creator><creator>Birner, Armin</creator><creator>Rieger, Alexandra</creator><creator>Seebauer, Julia</creator><creator>Platzer, Martina</creator><creator>Hamm, Carlo</creator><creator>Maget, Alexander</creator><creator>Queissner, Robert</creator><creator>Pilz, René</creator><creator>Fellendorf, Frederike T.</creator><creator>Reininghaus, Bernd</creator><creator>Strassnig, Martin T.</creator><creator>Kapfhammer, Hans-Peter</creator><creator>Weiss, Elisabeth M.</creator><creator>Reininghaus, Eva Z.</creator><general>Karger</general><scope>17B</scope><scope>BLEPL</scope><scope>DTL</scope><scope>DVR</scope><scope>EGQ</scope><scope>GIZIO</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7215-3848</orcidid><orcidid>https://orcid.org/0000-0003-1296-3448</orcidid></search><sort><creationdate>20210101</creationdate><title>Body Mass Index Predicts Decline in Executive Function in Bipolar Disorder: Preliminary Data of a 12-Month Follow-up Study</title><author>Dalkner, Nina ; 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| subjects | Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology Psychiatry Psychology Research Article Science & Technology Social Sciences |
| title | Body Mass Index Predicts Decline in Executive Function in Bipolar Disorder: Preliminary Data of a 12-Month Follow-up Study |
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