The Role of PTEN in Neurodevelopment

The Role of PTEN in Neurodevelopment

PTEN is a lipid and protein phosphatase that regulates cell growth and survival. Mutations to PTEN are highly penetrant for autism spectrum disorder (ASD). Here, we briefly review the evidence linking PTEN mutations to ASD and the mouse models that have been used to study the role of PTEN in neurode...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Complex psychiatry 2020-04, Vol.5 (Suppl 1), p.60-71
Hauptverfasser: Skelton, Patrick D., Stan, Radu V., Luikart, Bryan W.
Format: Artikel
Sprache:eng
Schlagworte:
Systematic Review
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 71
container_issue Suppl 1
container_start_page 60
container_title Complex psychiatry
container_volume 5
creator Skelton, Patrick D.
Stan, Radu V.
Luikart, Bryan W.
description PTEN is a lipid and protein phosphatase that regulates cell growth and survival. Mutations to PTEN are highly penetrant for autism spectrum disorder (ASD). Here, we briefly review the evidence linking PTEN mutations to ASD and the mouse models that have been used to study the role of PTEN in neurodevelopment. We then focus on the cellular phenotypes associated with PTEN loss in neurons, highlighting the role PTEN plays in neuronal proliferation, migration, survival, morphology, and plasticity.
doi_str_mv 10.1159/000504782
format Article
fullrecord <record><control><sourceid>proquest_karge</sourceid><recordid>TN_cdi_karger_primary_504782</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2402424509</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2802-ebbf3728375c12c142e3241788eb4dbee62f6f4468f229c28de8cf1dcb9ae5043</originalsourceid><addsrcrecordid>eNpt0M9LwzAUB_AgihtzB-8iBT3ooZq8pG1yHGP-gDmHTPBW2vRFp-1ak1XwvzfSupOnBPLJ9_G-hBwzesVYpK4ppREViYQ9MoQ44SEo-bLf37l_HJCxc--egWCQKHFIBhy4UiKhQ3K-esPgqS4xqE2wXM0WwXoTLLC1dYFfWNZNhZvtETkwWelw3J8j8nwzW03vwvnj7f10Mg81SAoh5rnhCUieRJqBZgKQ-5mJlJiLIkeMwcRGiFgaAOX_FCi1YYXOVYZ-Bz4iF11uY-vPFt02rdZOY1lmG6xbl4LwO4CIqPL0sqPa1s5ZNGlj11Vmv1NG099e0l0v3p72sW1eYbGTfy14cNaBj8y-ot2Bh8Wyi0ibwnh18q_qp_wAGQpvBA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2402424509</pqid></control><display><type>article</type><title>The Role of PTEN in Neurodevelopment</title><source>Karger Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Skelton, Patrick D. ; Stan, Radu V. ; Luikart, Bryan W.</creator><creatorcontrib>Skelton, Patrick D. ; Stan, Radu V. ; Luikart, Bryan W.</creatorcontrib><description>PTEN is a lipid and protein phosphatase that regulates cell growth and survival. Mutations to PTEN are highly penetrant for autism spectrum disorder (ASD). Here, we briefly review the evidence linking PTEN mutations to ASD and the mouse models that have been used to study the role of PTEN in neurodevelopment. We then focus on the cellular phenotypes associated with PTEN loss in neurons, highlighting the role PTEN plays in neuronal proliferation, migration, survival, morphology, and plasticity.</description><identifier>ISSN: 2673-3005</identifier><identifier>ISSN: 2296-9209</identifier><identifier>EISSN: 2673-298X</identifier><identifier>DOI: 10.1159/000504782</identifier><identifier>PMID: 32399470</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Systematic Review</subject><ispartof>Complex psychiatry, 2020-04, Vol.5 (Suppl 1), p.60-71</ispartof><rights>2020 S. Karger AG, Basel</rights><rights>Copyright © 2019 by S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2802-ebbf3728375c12c142e3241788eb4dbee62f6f4468f229c28de8cf1dcb9ae5043</citedby><cites>FETCH-LOGICAL-c2802-ebbf3728375c12c142e3241788eb4dbee62f6f4468f229c28de8cf1dcb9ae5043</cites><orcidid>0000-0002-6691-9904</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32399470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Skelton, Patrick D.</creatorcontrib><creatorcontrib>Stan, Radu V.</creatorcontrib><creatorcontrib>Luikart, Bryan W.</creatorcontrib><title>The Role of PTEN in Neurodevelopment</title><title>Complex psychiatry</title><addtitle>Complex Psychiatry</addtitle><description>PTEN is a lipid and protein phosphatase that regulates cell growth and survival. Mutations to PTEN are highly penetrant for autism spectrum disorder (ASD). Here, we briefly review the evidence linking PTEN mutations to ASD and the mouse models that have been used to study the role of PTEN in neurodevelopment. We then focus on the cellular phenotypes associated with PTEN loss in neurons, highlighting the role PTEN plays in neuronal proliferation, migration, survival, morphology, and plasticity.</description><subject>Systematic Review</subject><issn>2673-3005</issn><issn>2296-9209</issn><issn>2673-298X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpt0M9LwzAUB_AgihtzB-8iBT3ooZq8pG1yHGP-gDmHTPBW2vRFp-1ak1XwvzfSupOnBPLJ9_G-hBwzesVYpK4ppREViYQ9MoQ44SEo-bLf37l_HJCxc--egWCQKHFIBhy4UiKhQ3K-esPgqS4xqE2wXM0WwXoTLLC1dYFfWNZNhZvtETkwWelw3J8j8nwzW03vwvnj7f10Mg81SAoh5rnhCUieRJqBZgKQ-5mJlJiLIkeMwcRGiFgaAOX_FCi1YYXOVYZ-Bz4iF11uY-vPFt02rdZOY1lmG6xbl4LwO4CIqPL0sqPa1s5ZNGlj11Vmv1NG099e0l0v3p72sW1eYbGTfy14cNaBj8y-ot2Bh8Wyi0ibwnh18q_qp_wAGQpvBA</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Skelton, Patrick D.</creator><creator>Stan, Radu V.</creator><creator>Luikart, Bryan W.</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6691-9904</orcidid></search><sort><creationdate>202004</creationdate><title>The Role of PTEN in Neurodevelopment</title><author>Skelton, Patrick D. ; Stan, Radu V. ; Luikart, Bryan W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2802-ebbf3728375c12c142e3241788eb4dbee62f6f4468f229c28de8cf1dcb9ae5043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Systematic Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Skelton, Patrick D.</creatorcontrib><creatorcontrib>Stan, Radu V.</creatorcontrib><creatorcontrib>Luikart, Bryan W.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Complex psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skelton, Patrick D.</au><au>Stan, Radu V.</au><au>Luikart, Bryan W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of PTEN in Neurodevelopment</atitle><jtitle>Complex psychiatry</jtitle><addtitle>Complex Psychiatry</addtitle><date>2020-04</date><risdate>2020</risdate><volume>5</volume><issue>Suppl 1</issue><spage>60</spage><epage>71</epage><pages>60-71</pages><issn>2673-3005</issn><issn>2296-9209</issn><eissn>2673-298X</eissn><abstract>PTEN is a lipid and protein phosphatase that regulates cell growth and survival. Mutations to PTEN are highly penetrant for autism spectrum disorder (ASD). Here, we briefly review the evidence linking PTEN mutations to ASD and the mouse models that have been used to study the role of PTEN in neurodevelopment. We then focus on the cellular phenotypes associated with PTEN loss in neurons, highlighting the role PTEN plays in neuronal proliferation, migration, survival, morphology, and plasticity.</abstract><cop>Basel, Switzerland</cop><pmid>32399470</pmid><doi>10.1159/000504782</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-6691-9904</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2673-3005
ispartof Complex psychiatry, 2020-04, Vol.5 (Suppl 1), p.60-71
issn 2673-3005
2296-9209
2673-298X
language eng
recordid cdi_karger_primary_504782
source Karger Journals; PubMed Central; Alma/SFX Local Collection
subjects Systematic Review
title The Role of PTEN in Neurodevelopment
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T09%3A59%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_karge&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Role%20of%20PTEN%20in%20Neurodevelopment&rft.jtitle=Complex%20psychiatry&rft.au=Skelton,%20Patrick%C2%A0D.&rft.date=2020-04&rft.volume=5&rft.issue=Suppl%201&rft.spage=60&rft.epage=71&rft.pages=60-71&rft.issn=2673-3005&rft.eissn=2673-298X&rft_id=info:doi/10.1159/000504782&rft_dat=%3Cproquest_karge%3E2402424509%3C/proquest_karge%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2402424509&rft_id=info:pmid/32399470&rfr_iscdi=true