Autotaxin Inhibitor Protects from Chronic Allograft Injury in Rat Kidney Allotransplantation

Background: Tissue fibrosis is the final common phase of chronic allograft injury, the leading cause of late graft loss in kidney transplantation. Preclinical evidence points to the involvement of lysophosphatidic acid (LPA), a bioactive phospholipid, in the development of renal fibrosis. Objectives...

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Veröffentlicht in:	Nephron (2015) 2020-01, Vol.144 (1), p.38-48
Hauptverfasser:	Cortinovis, Monica, Aiello, Sistiana, Mister, Marilena, Conde-Knape, Karin, Noris, Marina, Novelli, Rubina, Solini, Samantha, Rodriguez Ordonez, Pamela Y., Benigni, Ariela, Remuzzi, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chronic Disease Experimental Nephrology and Genetics: Research Article Graft Rejection Kidney - metabolism Kidney Transplantation - adverse effects Lysophospholipids - metabolism Male Phosphoric Diester Hydrolases - drug effects Rats Rats, Inbred Strains Transplantation, Homologous - adverse effects
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