Conjunctival Melanoma in Childhood and Adolescence: A Systematic Review

Background: Conjunctival melanoma is rare in adults and rarer in children. We systematically reviewed the presentation, diagnostic and management strategies as well as outcomes for conjunctival melanoma in children and adolescents. Methods: The following databases were searched: Medline, Embase, Web...

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Veröffentlicht in:Ocular oncology and pathology 2019-10, Vol.5 (6), p.387-395
Hauptverfasser: Balzer, Ben W.R., Cherepanoff, Svetlana, Joshua, Anthony M., Giblin, Michael, Conway, Robert Max, Anazodo, Antoinette C.
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container_end_page 395
container_issue 6
container_start_page 387
container_title Ocular oncology and pathology
container_volume 5
creator Balzer, Ben W.R.
Cherepanoff, Svetlana
Joshua, Anthony M.
Giblin, Michael
Conway, Robert Max
Anazodo, Antoinette C.
description Background: Conjunctival melanoma is rare in adults and rarer in children. We systematically reviewed the presentation, diagnostic and management strategies as well as outcomes for conjunctival melanoma in children and adolescents. Methods: The following databases were searched: Medline, Embase, Web of Science and Scopus for cases of conjunctival melanoma occurring in children and adolescents < 18 years of age. Results: Seventeen studies with 32 patients (18 males) were identified. The median age at presentation was 11 years (range 4–18 years). Most patients were white. Most patients presented with a conjunctival mass or naevus with a recent history of growth or change. Excision biopsy provided diagnosis and management for all cases. Adjuvant chemotherapy and radiotherapy were also used. One patient had metastatic disease at diagnosis and 3 developed metastatic disease (range 1–10 months). Two patients died from disease and one was alive with metastatic disease. Two patients had disease recurrence. Outcomes were observed to be better where diagnosis was made earlier and “no-touch” excision biopsy was performed in an appropriate specialist setting. Conclusions: Conjunctival melanoma occurs rarely in children and adolescents. Surgery is the mainstay of management. The prognosis is guarded in metastatic disease due to the small sample size and limited follow-up.
doi_str_mv 10.1159/000497813
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We systematically reviewed the presentation, diagnostic and management strategies as well as outcomes for conjunctival melanoma in children and adolescents. Methods: The following databases were searched: Medline, Embase, Web of Science and Scopus for cases of conjunctival melanoma occurring in children and adolescents &lt; 18 years of age. Results: Seventeen studies with 32 patients (18 males) were identified. The median age at presentation was 11 years (range 4–18 years). Most patients were white. Most patients presented with a conjunctival mass or naevus with a recent history of growth or change. Excision biopsy provided diagnosis and management for all cases. Adjuvant chemotherapy and radiotherapy were also used. One patient had metastatic disease at diagnosis and 3 developed metastatic disease (range 1–10 months). Two patients died from disease and one was alive with metastatic disease. Two patients had disease recurrence. Outcomes were observed to be better where diagnosis was made earlier and “no-touch” excision biopsy was performed in an appropriate specialist setting. Conclusions: Conjunctival melanoma occurs rarely in children and adolescents. Surgery is the mainstay of management. The prognosis is guarded in metastatic disease due to the small sample size and limited follow-up.</description><identifier>ISSN: 2296-4681</identifier><identifier>EISSN: 2296-4657</identifier><identifier>DOI: 10.1159/000497813</identifier><identifier>PMID: 31768361</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Review ; Review Article</subject><ispartof>Ocular oncology and pathology, 2019-10, Vol.5 (6), p.387-395</ispartof><rights>2019 S. Karger AG, Basel</rights><rights>Copyright © 2019 by S. Karger AG, Basel.</rights><rights>Copyright © 2019 by S. 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Review Article
title Conjunctival Melanoma in Childhood and Adolescence: A Systematic Review
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