Pro-Angiogenic Role of LncRNA HULC in Microvascular Endothelial Cells via Sequestrating miR-124

HULC is a multifunctional lncRNA that has pro-angiogenic function in various cancers. The present study was designed to see the role of lncRNA HULC in normal endothelial cells angiogenesis. Cell viability, apoptosis, migration, tube formation and expression levels of angiogenesis-related proteins we...

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Veröffentlicht in:	Cellular physiology and biochemistry 2018-01, Vol.50 (6), p.2188-2202
Hauptverfasser:	Yin, Dexin, Li, Yezhou, Fu, Changgeng, Feng, Ye
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Antagomirs - metabolism Atherosclerosis bcl-2-Associated X Protein - metabolism Caspase 3 - metabolism Cell Line Cell Movement Cell Survival DNA methylation Endothelial Cells - cytology Endothelial Cells - metabolism HMEC-1 cell Humans Kinases Liver cancer LncRNA HULC MCL-1 MicroRNAs MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism miR-124 Myeloid Cell Leukemia Sequence 1 Protein - chemistry Myeloid Cell Leukemia Sequence 1 Protein - genetics Myeloid Cell Leukemia Sequence 1 Protein - metabolism Neovascularization, Physiologic Nitric oxide Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Retracted Paper RNA Interference RNA, Long Noncoding - antagonists & inhibitors RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Small Interfering - metabolism Signal Transduction STAT3 Transcription Factor - metabolism Vascular Endothelial Growth Factor A - metabolism
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