Mechanisms of Hydrogen Sulfide against the Progression of Severe Alzheimer’s Disease in Transgenic Mice at Different Ages

Backgroud: Alzheimer disease is an age-related severe neurodegenerative pathology. The level of the third endogenous gas, hydrogen sulfide (H 2 S), is decreased in the brain of Alzheimer’s disease (AD) patients compared with the brain of the age-matched normal individuals; also, plasma H 2 S levels...

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Veröffentlicht in:	Pharmacology 2019-01, Vol.103 (1-2), p.50-60
Hauptverfasser:	Vandini, Eleonora, Ottani, Alessandra, Zaffe, Davide, Calevro, Anita, Canalini, Fabrizio, Cavallini, Gian Maria, Rossi, Rosario, Guarini, Salvatore, Giuliani, Daniela
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Alzheimer Disease - drug therapy Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - metabolism Animals Brain - drug effects Brain - metabolism Brain - pathology Cerebellar Cortex - drug effects Cerebellar Cortex - metabolism Disease Models, Animal Hippocampus - drug effects Hippocampus - metabolism Hydrogen Sulfide - pharmacology Male MAP Kinase Kinase 7 - metabolism MAP Kinase Kinase Kinase 3 - metabolism Maze Learning - drug effects Mice Mice, Transgenic Plaque, Amyloid - metabolism Research Article tau Proteins - metabolism
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