Apelin-13 Administration Protects Against LPS-Induced Acute Lung Injury by Inhibiting NF-κB Pathway and NLRP3 Inflammasome Activation

Background/Aims: Acute lung injury (ALI) is induced by a variety of external and internal factors and leads to acute progressive respiratory failure. Previous studies have shown that apelin-13 can decrease the acute lung injury induced by LPS, but the specific mechanism is unclear. Therefore, a mous...

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Veröffentlicht in:	Cellular physiology and biochemistry 2018-01, Vol.49 (5), p.1918-1932
Hauptverfasser:	Zhang, Hailin, Chen, Sha, Zeng, Meichun, Lin, Daopeng, Wang, Yu, Wen, Xunhang, Xu, Changfu, Yang, Li, Fan, Xiaofang, Gong, Yongsheng, Zhang, Hongyu, Kong, Xiaoxia
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lung injury (ALI) Acute Lung Injury - etiology Acute Lung Injury - prevention & control Animals Apelin - pharmacology Apelin - therapeutic use Apelin-13 Apoptosis - drug effects Bronchoalveolar Lavage Fluid - chemistry Cytokines Cytokines - analysis Disease Models, Animal Inflammasomes - metabolism Inflammation Lipopolysaccharide (LPS) Lipopolysaccharides - toxicity Lung - drug effects Lung - metabolism Lung - pathology Lungs Male Membrane Potential, Mitochondrial - drug effects Mice Mice, Inbred C57BL NF-kappa B - metabolism NF-κB Nitric oxide NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 Original Paper Pathogenesis Peptides Physiology Protective Agents - pharmacology Protective Agents - therapeutic use Proteins RAW 264.7 Cells Reactive oxygen species Reactive Oxygen Species - metabolism Respiratory distress syndrome Sepsis Signal Transduction - drug effects Tumor necrosis factor-TNF
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