Differential Effects of 3,5-Diiodo-L-Thyronine and 3,5,3’-Triiodo-L-Thyronine On Mitochondrial Respiratory Pathways in Liver from Hypothyroid Rats

Background/Aims: Both 3,5-diiodo-L-thyronine (3,5-T2) and 3,5,3’-triiodo-L-tyronine (T3) affect energy metabolism having mitochondria as a major target. However, the underlying mechanisms are poorly understood. Here, using a model of chemically induced hypothyroidism in male Wistar rats, we investig...

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Veröffentlicht in:	Cellular physiology and biochemistry 2018-01, Vol.47 (6), p.2471-2483
Hauptverfasser:	Silvestri, Elena, Lombardi, Assunta, Coppola, Maria, Gentile, Alessandra, Cioffi, Federica, Senese, Rosalba, Goglia, Fernando, Lanni, Antonia, Moreno, Maria, de Lange, Pieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioenergetics Control theory Diiodothyronine Diiodothyronines - pharmacology Electron Transport - drug effects Energy metabolism Enzymes Hypothyroidism Hypothyroidism - drug therapy Hypothyroidism - metabolism Hypothyroidism - pathology Lipids Liver Male Metabolism Mitochondria Mitochondria, Liver - metabolism Mitochondria, Liver - pathology Mitochondrial DNA Musculoskeletal system Original Paper Phosphorylation Rats Rats, Wistar Respiration Rodents Thyroid gland Thyroid hormones Triiodothyronine - pharmacology
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