Chronic Prenatal Hypoxia Down-Regulated BK Channel Β1 Subunits in Mesenteric Artery Smooth Muscle Cells of the Offspring

Background/Aims: Chronic hypoxia in utero could impair vascular functions in the offspring, underlying mechanisms are unclear. This study investigated functional alteration in large-conductance Ca 2+ -activated K + (BK) channels in offspring mesenteric arteries following prenatal hypoxia. Methods: P...

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Veröffentlicht in:	Cellular physiology and biochemistry 2018, Vol.45 (4), p.1603-1616
Hauptverfasser:	Liu, Bailin, Liu, Yanping, Shi, Ruixiu, Feng, Xueqin, Li, Xiang, Zhang, Wenna, Wu, Jue, Li, Na, Zhou, Xiuwen, Sun, Miao, Xu, Zhice
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bk channel Blood pressure Blood Pressure - drug effects Chronic illnesses Diabetes Down-Regulation Female Fetal Hypoxia Gene expression Gestational Age Hypertension Hypoxia Laboratory animals Large-Conductance Calcium-Activated Potassium Channels - genetics Large-Conductance Calcium-Activated Potassium Channels - metabolism Male Membrane Potentials - drug effects Mesenteric Arteries - cytology Mesenteric Arteries - drug effects Mesenteric Arteries - metabolism Mesenteric artery Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - physiology Original Paper Patch-Clamp Techniques Peptides - pharmacology Phenylephrine - pharmacology Potassium Pregnancy Prenatal hypoxia Protein Subunits - genetics Protein Subunits - metabolism Pulmonary arteries Rats Rats, Sprague-Dawley Rodents Smooth muscle Smooth muscle cells Tamoxifen - pharmacology Tetrazoles - pharmacology Thiourea - analogs & derivatives Thiourea - pharmacology Vasoconstriction - drug effects Veins & arteries β1-subunit
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