Do Statins Affect Thyroid Volume and Nodule Size in Patients with Hyperlipidemia in a Region with Mild-to-Moderate Iodine Deficiency? A Prospective Study
Objective: The objective of this study was to assess the antiproliferative pleiotropic effects of statins on thyroid function, volume, and nodularity. Subjects and Methods: One hundred and six hyperlipidemic patients were included in this prospective study. The 69 patients in the statin groups recei...
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description | Objective: The objective of this study was to assess the antiproliferative pleiotropic effects of statins on thyroid function, volume, and nodularity. Subjects and Methods: One hundred and six hyperlipidemic patients were included in this prospective study. The 69 patients in the statin groups received atorvastatin (16 received 10 mg and 18 received 20 mg) or rosuvastatin (20 received 10 mg and 15 received 20 mg). The 37 patients in the control group, assessed as not requiring drugs, made only lifestyle changes. Upon admission and after 6 months, all patients were evaluated by ultrasonography as well as for lipid variables (total cholesterol, high- and low-density lipoprotein cholesterol, and triglycerides) and thyroid function and structure. Results: After 6 months, no differences in thyroid function, thyroid volume, the number of thyroid nodules, or nodule size were observed in the statin and control groups. In a subgroup analysis, total thyroid volume had decreased more in patients receiving 20 mg of rosuvastatin than that in the control group (p < 0.05). Maximum nodule size had decreased more in those receiving 10 mg of rosuvastatin (p < 0.05). Conclusions: Our results suggest an association between rosuvastatin treatment and smaller thyroid volume and maximum nodule diameter; this could be attributable to the antiproliferative effects of statin therapy on the thyroid. |
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A Prospective Study</title><source>DOAJ Directory of Open Access Journals</source><source>Karger Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Demir, Canan ; Anil, Cuneyd ; Bozkus, Yusuf ; Mousa, Umut ; Kut, Altug ; Nar, Asli ; Tutuncu, Neslihan B.</creator><creatorcontrib>Demir, Canan ; Anil, Cuneyd ; Bozkus, Yusuf ; Mousa, Umut ; Kut, Altug ; Nar, Asli ; Tutuncu, Neslihan B.</creatorcontrib><description>Objective: The objective of this study was to assess the antiproliferative pleiotropic effects of statins on thyroid function, volume, and nodularity. Subjects and Methods: One hundred and six hyperlipidemic patients were included in this prospective study. The 69 patients in the statin groups received atorvastatin (16 received 10 mg and 18 received 20 mg) or rosuvastatin (20 received 10 mg and 15 received 20 mg). The 37 patients in the control group, assessed as not requiring drugs, made only lifestyle changes. Upon admission and after 6 months, all patients were evaluated by ultrasonography as well as for lipid variables (total cholesterol, high- and low-density lipoprotein cholesterol, and triglycerides) and thyroid function and structure. Results: After 6 months, no differences in thyroid function, thyroid volume, the number of thyroid nodules, or nodule size were observed in the statin and control groups. In a subgroup analysis, total thyroid volume had decreased more in patients receiving 20 mg of rosuvastatin than that in the control group (p < 0.05). Maximum nodule size had decreased more in those receiving 10 mg of rosuvastatin (p < 0.05). Conclusions: Our results suggest an association between rosuvastatin treatment and smaller thyroid volume and maximum nodule diameter; this could be attributable to the antiproliferative effects of statin therapy on the thyroid.</description><identifier>ISSN: 1011-7571</identifier><identifier>EISSN: 1423-0151</identifier><identifier>DOI: 10.1159/000486748</identifier><identifier>PMID: 29402848</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Apoptosis ; Cancer therapies ; Cardiovascular disease ; Cell growth ; Cholesterol ; Endocrinology ; Epidermal growth factor ; Hyperlipidemia ; Iodine ; Kinases ; Lifestyles ; Metastasis ; Morphology ; Mutation ; Original Paper ; Prostate ; Protein synthesis ; Proteins ; Statins ; Substance abuse treatment ; Thyroid cancer ; Thyroid diseases ; Volumetric analysis</subject><ispartof>Medical principles and practice, 2018-01, Vol.27 (1), p.1-7</ispartof><rights>2018 The Author(s) Published by S. Karger AG, Basel</rights><rights>2018 The Author(s) Published by S. Karger AG, Basel.</rights><rights>Copyright © 2018 by S. Karger AG, Basel 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-5fa4d12880010450a677d48c202bb25394703fa003b3711224456bdf60642fd73</citedby><cites>FETCH-LOGICAL-c452t-5fa4d12880010450a677d48c202bb25394703fa003b3711224456bdf60642fd73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968300/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968300/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27635,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29402848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Demir, Canan</creatorcontrib><creatorcontrib>Anil, Cuneyd</creatorcontrib><creatorcontrib>Bozkus, Yusuf</creatorcontrib><creatorcontrib>Mousa, Umut</creatorcontrib><creatorcontrib>Kut, Altug</creatorcontrib><creatorcontrib>Nar, Asli</creatorcontrib><creatorcontrib>Tutuncu, Neslihan B.</creatorcontrib><title>Do Statins Affect Thyroid Volume and Nodule Size in Patients with Hyperlipidemia in a Region with Mild-to-Moderate Iodine Deficiency? A Prospective Study</title><title>Medical principles and practice</title><addtitle>Med Princ Pract</addtitle><description>Objective: The objective of this study was to assess the antiproliferative pleiotropic effects of statins on thyroid function, volume, and nodularity. Subjects and Methods: One hundred and six hyperlipidemic patients were included in this prospective study. The 69 patients in the statin groups received atorvastatin (16 received 10 mg and 18 received 20 mg) or rosuvastatin (20 received 10 mg and 15 received 20 mg). The 37 patients in the control group, assessed as not requiring drugs, made only lifestyle changes. Upon admission and after 6 months, all patients were evaluated by ultrasonography as well as for lipid variables (total cholesterol, high- and low-density lipoprotein cholesterol, and triglycerides) and thyroid function and structure. Results: After 6 months, no differences in thyroid function, thyroid volume, the number of thyroid nodules, or nodule size were observed in the statin and control groups. In a subgroup analysis, total thyroid volume had decreased more in patients receiving 20 mg of rosuvastatin than that in the control group (p < 0.05). Maximum nodule size had decreased more in those receiving 10 mg of rosuvastatin (p < 0.05). Conclusions: Our results suggest an association between rosuvastatin treatment and smaller thyroid volume and maximum nodule diameter; this could be attributable to the antiproliferative effects of statin therapy on the thyroid.</description><subject>Apoptosis</subject><subject>Cancer therapies</subject><subject>Cardiovascular disease</subject><subject>Cell growth</subject><subject>Cholesterol</subject><subject>Endocrinology</subject><subject>Epidermal growth factor</subject><subject>Hyperlipidemia</subject><subject>Iodine</subject><subject>Kinases</subject><subject>Lifestyles</subject><subject>Metastasis</subject><subject>Morphology</subject><subject>Mutation</subject><subject>Original Paper</subject><subject>Prostate</subject><subject>Protein synthesis</subject><subject>Proteins</subject><subject>Statins</subject><subject>Substance abuse treatment</subject><subject>Thyroid cancer</subject><subject>Thyroid diseases</subject><subject>Volumetric analysis</subject><issn>1011-7571</issn><issn>1423-0151</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkUtv1DAUhSMEomVgwR4hS93AIuDrRx6bolELtFIHRrSwtZzYmXFJ4mA7ReGf8G9xlRIBYmVL5_O55_okyVPArwB4-RpjzIosZ8W95BAYoSkGDvfjHQOkOc_hIHnk_XXECkrxw-SAlAyTghWHyc9Tiy6DDKb3aN00ug7oaj85axT6Ytux00j2Cn2wamw1ujQ_NDI92kZe98Gj7ybs0dk0aNeawSjdGXmrS_RJ74ztZ31jWpUGm26s0k4Gjc6tMr1Gp7oxdfSppzdojbbO-iGONzdxThjV9Dh50MjW6yd35yr5_O7t1clZevHx_fnJ-iKtGSch5Y1kCkhRYAyYcSyzPFesqAkmVUU4LVmOaSMxphXNAQhhjGeVajKcMdKonK6S49l3GKtOqzou5mQrBmc66SZhpRF_K73Zi529EbzMChp9V8mLOwNnv43aB9EZX-u2lb22oxdQlhwyoAQievQPem1H18f1BAHIgce8JFIvZ6qOf-KdbpYwgMVt4WIpPLLP_0y_kL8bjsCzGfgq3U67BVjeH_1X3my3MyEG1dBfyDu6gA</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Demir, Canan</creator><creator>Anil, Cuneyd</creator><creator>Bozkus, Yusuf</creator><creator>Mousa, Umut</creator><creator>Kut, Altug</creator><creator>Nar, Asli</creator><creator>Tutuncu, Neslihan B.</creator><general>S. 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A Prospective Study</title><author>Demir, Canan ; Anil, Cuneyd ; Bozkus, Yusuf ; Mousa, Umut ; Kut, Altug ; Nar, Asli ; Tutuncu, Neslihan B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-5fa4d12880010450a677d48c202bb25394703fa003b3711224456bdf60642fd73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Apoptosis</topic><topic>Cancer therapies</topic><topic>Cardiovascular disease</topic><topic>Cell growth</topic><topic>Cholesterol</topic><topic>Endocrinology</topic><topic>Epidermal growth factor</topic><topic>Hyperlipidemia</topic><topic>Iodine</topic><topic>Kinases</topic><topic>Lifestyles</topic><topic>Metastasis</topic><topic>Morphology</topic><topic>Mutation</topic><topic>Original Paper</topic><topic>Prostate</topic><topic>Protein synthesis</topic><topic>Proteins</topic><topic>Statins</topic><topic>Substance abuse treatment</topic><topic>Thyroid cancer</topic><topic>Thyroid diseases</topic><topic>Volumetric analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Demir, Canan</creatorcontrib><creatorcontrib>Anil, Cuneyd</creatorcontrib><creatorcontrib>Bozkus, Yusuf</creatorcontrib><creatorcontrib>Mousa, Umut</creatorcontrib><creatorcontrib>Kut, Altug</creatorcontrib><creatorcontrib>Nar, Asli</creatorcontrib><creatorcontrib>Tutuncu, Neslihan B.</creatorcontrib><collection>Karger Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical principles and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Demir, Canan</au><au>Anil, Cuneyd</au><au>Bozkus, Yusuf</au><au>Mousa, Umut</au><au>Kut, Altug</au><au>Nar, Asli</au><au>Tutuncu, Neslihan B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Do Statins Affect Thyroid Volume and Nodule Size in Patients with Hyperlipidemia in a Region with Mild-to-Moderate Iodine Deficiency? A Prospective Study</atitle><jtitle>Medical principles and practice</jtitle><addtitle>Med Princ Pract</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>27</volume><issue>1</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>1011-7571</issn><eissn>1423-0151</eissn><abstract>Objective: The objective of this study was to assess the antiproliferative pleiotropic effects of statins on thyroid function, volume, and nodularity. Subjects and Methods: One hundred and six hyperlipidemic patients were included in this prospective study. The 69 patients in the statin groups received atorvastatin (16 received 10 mg and 18 received 20 mg) or rosuvastatin (20 received 10 mg and 15 received 20 mg). The 37 patients in the control group, assessed as not requiring drugs, made only lifestyle changes. Upon admission and after 6 months, all patients were evaluated by ultrasonography as well as for lipid variables (total cholesterol, high- and low-density lipoprotein cholesterol, and triglycerides) and thyroid function and structure. Results: After 6 months, no differences in thyroid function, thyroid volume, the number of thyroid nodules, or nodule size were observed in the statin and control groups. In a subgroup analysis, total thyroid volume had decreased more in patients receiving 20 mg of rosuvastatin than that in the control group (p < 0.05). Maximum nodule size had decreased more in those receiving 10 mg of rosuvastatin (p < 0.05). Conclusions: Our results suggest an association between rosuvastatin treatment and smaller thyroid volume and maximum nodule diameter; this could be attributable to the antiproliferative effects of statin therapy on the thyroid.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>29402848</pmid><doi>10.1159/000486748</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Apoptosis Cancer therapies Cardiovascular disease Cell growth Cholesterol Endocrinology Epidermal growth factor Hyperlipidemia Iodine Kinases Lifestyles Metastasis Morphology Mutation Original Paper Prostate Protein synthesis Proteins Statins Substance abuse treatment Thyroid cancer Thyroid diseases Volumetric analysis |
title | Do Statins Affect Thyroid Volume and Nodule Size in Patients with Hyperlipidemia in a Region with Mild-to-Moderate Iodine Deficiency? A Prospective Study |
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