Cetuximab Enhanced the Cytotoxic Activity of Immune Cells during Treatment of Colorectal Cancer

Background/Aims: Cetuximab is a chimeric IgG1 monoclonal antibody which targets the extracellular domain of epidermal growth factor receptor. This antibody is widely used for colorectal cancer (CRC) treatment but its influence on the immune system is incompletely understood. Methods: The immune infl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cellular Physiology and Biochemistry 2017-01, Vol.44 (3), p.1038-1050
Hauptverfasser:	Wang, Lin, Wei, Yingfeng, Fang, Weijia, Lu, Chong, Chen, Jianing, Cui, Guangying, Diao, Hongyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Agents, Immunological - pharmacology Antineoplastic Agents, Immunological - therapeutic use Cancer therapies CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism CD8+T cells CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - metabolism Cells, Cultured Cetuximab Cetuximab - pharmacology Cetuximab - therapeutic use Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Cytokines - blood Drug dosages Drug therapy Epidermal growth factor FDA approval Female HT29 Cells Humans Immunotherapy K562 Cells Killer Cells, Natural - cytology Killer Cells, Natural - drug effects Killer Cells, Natural - metabolism Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - metabolism Lymphocytes Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - immunology Lysosomal-Associated Membrane Protein 1 - metabolism Male Metastasis Middle Aged Monoclonal antibodies Mortality NK cells Original Paper Patient outcomes T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - metabolism Targeted cancer therapy Tumor Necrosis Factor Receptor Superfamily, Member 9 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!