Downregulation of Striatal Dopamine D2 Receptors in Advanced Parkinson’s Disease Contributes to the Development of Motor Fluctuation
The purpose of this study was to evaluate the contribution of the postsynaptic mechanism to the development of motor fluctuation in advanced Parkinson’s disease (PD). We used 123 I-iodobenzamide single-photon emission computed tomography to measure the striatal dopamine D2 receptor densities in earl...
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| Veröffentlicht in: | European neurology 2002-01, Vol.47 (2), p.113-117 |
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| creator | Hwang, Wen-Juh Yao, Wei-Jen Wey, Shiaw-Pyng Shen, Lie-Hang Ting, Gann |
| description | The purpose of this study was to evaluate the contribution of the postsynaptic mechanism to the development of motor fluctuation in advanced Parkinson’s disease (PD). We used 123 I-iodobenzamide single-photon emission computed tomography to measure the striatal dopamine D2 receptor densities in early levodopa-naïve PD, chronic PD with stable levodopa response, and advanced PD with fluctuating levodopa response. The basal ganglia/frontal cortex ratios at both hemispheres were calculated and averaged. PD patients with fluctuating levodopa response showed a significant decrease in striatal dopamine D2 receptor densities compared to those with early (1.57 ± 0.20 vs. 1.77 ± 0.12, p = 0.009) or chronic stable PD (1.57 ± 0.20 vs. 1.77 ± 0.10, p = 0.024). We conclude that the decreased D2 receptor densities in advanced PD reduced the ‘safety factor’ for synaptic transmission and contributed to the development of motor fluctuation. |
| doi_str_mv | 10.1159/000047962 |
| format | Article |
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We used 123 I-iodobenzamide single-photon emission computed tomography to measure the striatal dopamine D2 receptor densities in early levodopa-naïve PD, chronic PD with stable levodopa response, and advanced PD with fluctuating levodopa response. The basal ganglia/frontal cortex ratios at both hemispheres were calculated and averaged. PD patients with fluctuating levodopa response showed a significant decrease in striatal dopamine D2 receptor densities compared to those with early (1.57 ± 0.20 vs. 1.77 ± 0.12, p = 0.009) or chronic stable PD (1.57 ± 0.20 vs. 1.77 ± 0.10, p = 0.024). We conclude that the decreased D2 receptor densities in advanced PD reduced the ‘safety factor’ for synaptic transmission and contributed to the development of motor fluctuation.</description><identifier>ISSN: 0014-3022</identifier><identifier>EISSN: 1421-9913</identifier><identifier>DOI: 10.1159/000047962</identifier><identifier>PMID: 11844900</identifier><identifier>CODEN: EUNEAP</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Aged ; Benzamides ; Biological and medical sciences ; Corpus Striatum - diagnostic imaging ; Corpus Striatum - drug effects ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Humans ; Iodine Radioisotopes ; Levodopa - adverse effects ; Levodopa - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Motor Skills - drug effects ; Neurologic Examination - drug effects ; Neurology ; Original Paper ; Parkinson Disease - diagnostic imaging ; Parkinson Disease - drug therapy ; Pyrrolidines ; Receptors, Dopamine D2 - drug effects ; Receptors, Dopamine D2 - physiology ; Synaptic Transmission - drug effects ; Synaptic Transmission - physiology ; Tomography, Emission-Computed, Single-Photon ; Tropical medicine</subject><ispartof>European neurology, 2002-01, Vol.47 (2), p.113-117</ispartof><rights>2002 S. Karger AG, Basel</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 S. Karger AG, Basel</rights><rights>Copyright S. Karger AG Feb 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-f52198c086beba6653c80c0a2c866ead6f2f9be600079835f6213d97f88478493</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13499760$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11844900$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hwang, Wen-Juh</creatorcontrib><creatorcontrib>Yao, Wei-Jen</creatorcontrib><creatorcontrib>Wey, Shiaw-Pyng</creatorcontrib><creatorcontrib>Shen, Lie-Hang</creatorcontrib><creatorcontrib>Ting, Gann</creatorcontrib><title>Downregulation of Striatal Dopamine D2 Receptors in Advanced Parkinson’s Disease Contributes to the Development of Motor Fluctuation</title><title>European neurology</title><addtitle>Eur Neurol</addtitle><description>The purpose of this study was to evaluate the contribution of the postsynaptic mechanism to the development of motor fluctuation in advanced Parkinson’s disease (PD). We used 123 I-iodobenzamide single-photon emission computed tomography to measure the striatal dopamine D2 receptor densities in early levodopa-naïve PD, chronic PD with stable levodopa response, and advanced PD with fluctuating levodopa response. The basal ganglia/frontal cortex ratios at both hemispheres were calculated and averaged. PD patients with fluctuating levodopa response showed a significant decrease in striatal dopamine D2 receptor densities compared to those with early (1.57 ± 0.20 vs. 1.77 ± 0.12, p = 0.009) or chronic stable PD (1.57 ± 0.20 vs. 1.77 ± 0.10, p = 0.024). We conclude that the decreased D2 receptor densities in advanced PD reduced the ‘safety factor’ for synaptic transmission and contributed to the development of motor fluctuation.</description><subject>Adult</subject><subject>Aged</subject><subject>Benzamides</subject><subject>Biological and medical sciences</subject><subject>Corpus Striatum - diagnostic imaging</subject><subject>Corpus Striatum - drug effects</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Humans</subject><subject>Iodine Radioisotopes</subject><subject>Levodopa - adverse effects</subject><subject>Levodopa - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Motor Skills - drug effects</subject><subject>Neurologic Examination - drug effects</subject><subject>Neurology</subject><subject>Original Paper</subject><subject>Parkinson Disease - diagnostic imaging</subject><subject>Parkinson Disease - drug therapy</subject><subject>Pyrrolidines</subject><subject>Receptors, Dopamine D2 - drug effects</subject><subject>Receptors, Dopamine D2 - physiology</subject><subject>Synaptic Transmission - drug effects</subject><subject>Synaptic Transmission - physiology</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Tropical medicine</subject><issn>0014-3022</issn><issn>1421-9913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpt0c9rFDEUB_Agit1WD54FCUIFD6NJJpNJjmV3q4X6A3-ch0zmpU47k4xJpuLNk_9D_z3_ErPdpQtiLo_Ah-97vIfQE0peUVqp1yQ_XivB7qEF5YwWStHyPloQQnlREsYO0GGMl_lbqVo-RAeUSs4VIQv0e-V_uAAX86BT7x32Fn9OoddJD3jlJz32DvCK4U9gYEo-RNw7fNJda2egwx91uOpd9O7Pr5uIV30EHQEvvcsR7Zwg4uRx-pYT4BoGP43g0qbFO5-j8OkwmzTf9n2EHlg9RHi8q0fo6-n6y_Jtcf7hzdny5LwwXLJU2IpRJQ2RooVWC1GVRhJDNDNSCNCdsMyqFkTeR61kWVnBaNmp2krJa8lVeYRebHOn4L_PEFMz9tHAMGgHfo4NI4pwwmWGz_-Bl34OLs_WUMUVY5XYoJdbZIKPMYBtptCPOvxsKGk2l2nuLpPts13g3I7Q7eXuFBkc74CORg825BX3ce9KrlQtyH6yKx0uINyB9fv1badm6mxGT_-LtrP8BROFqws</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Hwang, Wen-Juh</creator><creator>Yao, Wei-Jen</creator><creator>Wey, Shiaw-Pyng</creator><creator>Shen, Lie-Hang</creator><creator>Ting, Gann</creator><general>Karger</general><general>S. 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Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Humans</topic><topic>Iodine Radioisotopes</topic><topic>Levodopa - adverse effects</topic><topic>Levodopa - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Motor Skills - drug effects</topic><topic>Neurologic Examination - drug effects</topic><topic>Neurology</topic><topic>Original Paper</topic><topic>Parkinson Disease - diagnostic imaging</topic><topic>Parkinson Disease - drug therapy</topic><topic>Pyrrolidines</topic><topic>Receptors, Dopamine D2 - drug effects</topic><topic>Receptors, Dopamine D2 - physiology</topic><topic>Synaptic Transmission - drug effects</topic><topic>Synaptic Transmission - physiology</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hwang, Wen-Juh</creatorcontrib><creatorcontrib>Yao, Wei-Jen</creatorcontrib><creatorcontrib>Wey, Shiaw-Pyng</creatorcontrib><creatorcontrib>Shen, Lie-Hang</creatorcontrib><creatorcontrib>Ting, Gann</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><jtitle>European neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hwang, Wen-Juh</au><au>Yao, Wei-Jen</au><au>Wey, Shiaw-Pyng</au><au>Shen, Lie-Hang</au><au>Ting, Gann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Downregulation of Striatal Dopamine D2 Receptors in Advanced Parkinson’s Disease Contributes to the Development of Motor Fluctuation</atitle><jtitle>European neurology</jtitle><addtitle>Eur Neurol</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>47</volume><issue>2</issue><spage>113</spage><epage>117</epage><pages>113-117</pages><issn>0014-3022</issn><eissn>1421-9913</eissn><coden>EUNEAP</coden><abstract>The purpose of this study was to evaluate the contribution of the postsynaptic mechanism to the development of motor fluctuation in advanced Parkinson’s disease (PD). We used 123 I-iodobenzamide single-photon emission computed tomography to measure the striatal dopamine D2 receptor densities in early levodopa-naïve PD, chronic PD with stable levodopa response, and advanced PD with fluctuating levodopa response. The basal ganglia/frontal cortex ratios at both hemispheres were calculated and averaged. PD patients with fluctuating levodopa response showed a significant decrease in striatal dopamine D2 receptor densities compared to those with early (1.57 ± 0.20 vs. 1.77 ± 0.12, p = 0.009) or chronic stable PD (1.57 ± 0.20 vs. 1.77 ± 0.10, p = 0.024). We conclude that the decreased D2 receptor densities in advanced PD reduced the ‘safety factor’ for synaptic transmission and contributed to the development of motor fluctuation.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>11844900</pmid><doi>10.1159/000047962</doi><tpages>5</tpages></addata></record> |
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| ispartof | European neurology, 2002-01, Vol.47 (2), p.113-117 |
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| subjects | Adult Aged Benzamides Biological and medical sciences Corpus Striatum - diagnostic imaging Corpus Striatum - drug effects Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans Iodine Radioisotopes Levodopa - adverse effects Levodopa - therapeutic use Male Medical sciences Middle Aged Motor Skills - drug effects Neurologic Examination - drug effects Neurology Original Paper Parkinson Disease - diagnostic imaging Parkinson Disease - drug therapy Pyrrolidines Receptors, Dopamine D2 - drug effects Receptors, Dopamine D2 - physiology Synaptic Transmission - drug effects Synaptic Transmission - physiology Tomography, Emission-Computed, Single-Photon Tropical medicine |
| title | Downregulation of Striatal Dopamine D2 Receptors in Advanced Parkinson’s Disease Contributes to the Development of Motor Fluctuation |
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